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| 1 | Effects of luteinizing hormone and androgen on the development of rat progenitor Leydig cells in vitro and in vivo显示文摘祖先 Leydig 房间从干细胞被导出。祖先 Leydig 房间的增长和区别显著地在发身期间贡献 Leydig 房间数字。然而,这些过程的规定仍然保持不清楚。现在的学习的目的是决定 luteinizing 荷尔蒙(LH ) 或雄激素是否贡献祖先 Leydig 房间的增长和区别。Fourteen-day-old 男 Sprague-Dawley 老鼠与 NalGlu 被对待 7 天,它是一个释放 gonadotropin 荷尔蒙对手,到在垂体并且这样减少 LH 的分泌物,在睾丸的雄激素。老鼠与 LH 或 7 α 被共同管理; -methyl-nortestosterone (MENT ) 是对由 5 α 的新陈代谢抵抗的雄激素, -reductase 1 在祖先 Leydig 房间,和 LH 或雄激素的随后的效果被测量。3 H-Thymidine 静脉内地也被注入老鼠在祖先 Leydig 房间学习 thymidine 加入。祖先 Leydig 房间被检验。NalGlu 管理由 83 % 减少了祖先 Leydig 房间增长;。另外, LH 或 MENT 处理恢复了 Leydig 房间 proliferative 能力到 73 %或 50 %控制,分别地。增长相关的基因的送信人 RNA 层次用即时 PCR 被测量。Igf1, Lifr, Pdgfra, Bcl2, Ccnd3 和 Pcna 的表示层次是由 MENT 的 upregulated,并且 Pdgfra, Ccnd3 和 Pcna 的那些是由 LH 的 upregulated。LH 和 MENT 在 vitro 刺激了祖先 Leydig 房间的区别。我们断定 LH 和 MENT 涉及调整祖先 Leydig 房间的发展。 | Jing-Jing Guo Xue Ma Claire Q F Wang Yu-Fei Ge Qing-Quan Lian Dianne O Hard Yu-Fei Zhang Qiang Dong Yun-Fei Xu Ren-Shan Ge | 2013 | Asian Journal of Andrology2013，15，5： | 4 |
| 2 | Characterization of GATA3 mutations in the hypoparathyroidism,deafness,and renal dysplasia (HDR) syndrome显示文摘 | Nesbit MA Bowl MR Harding B | 2004 | J Biol Chem2004，279，22： | 1 |
| 3 | RREB1 transcription factor splice variants in urologic cancer显示文摘 | Nitz MD Harding MA Smith SC | 2011 | Am J Pathol2011，179，1： | 1 |
| 4 | The relationship of BRMS1 and RhoGD12 gene expression to metastatic potential in lineage related human bladder cancer cell lines 显示文摘 | Seraj MJ Harding MA Gildea JJ | 2001 | Clin Exp Metastasis2001，18，6： | 1 |
| 5 | Hypogly- cemic effects of steroidal sapogenins isolated from Jamai- can bitter yam, Dioscorea polygonoides 显示文摘 | McAnuff MA Harding WW Omoruyi FO | 2005 | Food Chem Toxico12005，43，11： | 1 |
| 6 | The role of vascular endothelial growth factor in the tissue specific in vivo growth of prostate cancer cells 显示文摘 | Krupski T Harding MA Herce ME | 2001 | Growth-Factors2001，18，4： | 1 |
| 7 | The relationship of BRMSl and RhoGDI gene expression to metastatic potential in lineage related human bladder cancer cell lines显示文摘 | Seraj M J Harding MA Gildea JJ | 2000 | Clin Exp Metastasis2000，15，6： | 1 |
| 8 | The role of Ral A in epidermal growth factor receptor-regulated cell motility显示文摘 | Gildea JJ Harding MA Seraj MJ | 2002 | Cancer Res2002，62，： | 1 |
| 9 | Molecular cloning and characterization of a lysophosphatidic acid receptor,edg-7,expressed in prostate显示文摘 | Im DS Heise CE Harding MA | 2000 | Mol Pharmacol2000，57，： | 1 |
| 10 | Attitudes to, and utilization of low molecular weight heparins in joint replacement surgery 显示文摘 | McNally MA Cook EA Harding ML | 1997 | JR coil Surg Eclinb1997，42，： | 1 |
| 11 | CD24 is an effector of HIF- l-driven primary tumor growth and metastasis显示文摘 | Thomas S Harding MA Smith SC | 2012 | Cancer Res2012，72，21： | 1 |
| 12 | RhoGDI Signaling provides targets for cancer therapy显示文摘 | Harding MA Theodorescu D | 2010 | Eur J Cancer2010，46，7： | 1 |
| 13 | The role of vascular endothelial growth factor in the tissue specific in vivo growth of prostate cancer cells显示文摘 | Harding MA Herce ME | 2001 | Growth-Factors2001，18，4： | 1 |
| 14 | The relationship of BRMS1 and RhoGDI2 gene expression to metastatic potential in lineage related human bladder cancer cell lines 显示文摘 | Seraj M J Harding MA Gildea JJ | 2000 | Clin Exp Metastasis2000，18，6： | 1 |
| 15 | PTEN can inhibit in vitro organ otypiean dinvivo orthotopie invasion of human bladder cancer ceils even in the absence of its lipid phosphatase activity显示文摘 | Gildea JJ Herlevsen M Harding MA | 2004 | Oncogene2004，23，40： | 1 |
| 16 | Genebanks:a comparison of eight proposed international genetic databases显示文摘 | Austin MA Harding S MeElroy C | 2003 | Community Genet2003，6，1： | 1 |
| 17 | The role ofvas- cular endothelial growth factor in the tissue specific in vi- vo growth ofprostate cancer cells显示文摘 | Krupski T Harding MA Herce ME | 2001 | Growth Factors2001，18，4： | 1 |
| 18 | Focal adhesion kinase, Rapl, and transcriptional in'duction of vascular endothelial growth factor 显示文摘 | Sheta EA Harding MA Conaway MR | 2000 | J Nat1 Cancer Inst2000，92，13： | 1 |
| 19 | The influence of some post - translational modifications on the chaperone - like aclivily of alpha- crystallin显示文摘 | van Boekel MA Hoogakker SE Harding JJ | 1996 | Ophthalmic Res1996，28，1： | 1 |
| 20 | Congenital trichomegaly, pigmentary retinal degeneration, and short stature 显示文摘 | Patton MA Harding AE Baraitser M | 1986 | Am J Ophthahnol1986，101，： | 1 |
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