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您的检索式：作者名="Haoxin YAO"
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| 1 | Upconversion nanoparticles regulated drug&gas dual-effective nanoplatform for the targeting cooperated therapy of thrombus and anticoagulation显示文摘Thromboembolism is the leading cause of cardiovascular mortality.Currently,for the lack of targeting,short half-life,low bioavailability and high bleeding risk of the classical thrombolytic drugs,pharmacological thrombolysis is usually a slow process based on micro-pumping.In addition,frequently monitoring and regulating coagulation functions are also required during(and after)the process of thrombolysis.To address these issues,a targeted thrombolytic and anticoagulation nanoplatform(UCATS-UK)is developed based on upconversion nanoparticles(UCNPs)that can convert 808 or 980 nm near-infrared(NIR)light into UV/blue light.This nanoplatform can target and enrich in the thrombus site.Synergistic thrombolysis and anticoagulation therapy thus could be realized through the controlled release of urokinase(UK)and nitric oxide(NO).Both in vitro and in vivo experiments have confirmed the excellent thrombolytic and anticoagulative capabilities of this multifunctional nanoplatform.Combined with the unique fluorescent imaging capability of UCNPs,this work is expected to contribute to the development of clinical thrombolysis therapy towards an integrated system of imaging,diagnosis and treatment. | Shichen Liu Yao Sun Teng Zhang Longtao Cao Zhiwei Zhong Haoxin Cheng Qingqing Wang Zhuang Qiu Weimin Zhou Xiaolei Wang | 2022 | Bioactive Materials2022，7，12： | 1 |
| 2 | The Warm Arctic-Cold Eurasia Pattern and Its Key Region in Winter in CMIP6 Model Simulations显示文摘An enhanced Warm Arctic-Cold Eurasia(WACE)pattern has been a notable feature in recent winters of the Northern Hemisphere.However,divergent results between model and observational studies of the WACE still remain.This study evaluates the performance of 39 climate models participating in the Coupled Model Intercomparison Project Phase 6(CMIP6)in simulating the WACE pattern in winter of 1980-2014 and explores the key factors causing the differences in the simulation capability among the models.The results show that the multimodel ensemble(MME)can better simulate the spatial distribution of the WACE pattern than most single models.Models that can/cannot simulate both the climatology and the standard deviation of the Eurasian winter surface air temperature well,especially the latter,usually can/cannot simulate the WACE pattern well.This mainly results from the different abilities of the models to simulate the range and intensity of the warm anomaly in the Barents Sea-Kara seas(BKS)region.Further analysis shows that a good performance of the models in the BKS area is usually related to their ability to simulate location and persistence of Ural blocking(UB),which can transport heat to the BKS region,causing the warm Arctic,and strengthen the westerly trough downstream,cooling central Eurasia.Therefore,simulation of UB is key and significantly affects the model’s performance in simulating the WACE. | Liang ZHAO Yunwen LIU Yihui DING Qingquan LI Wei DONG Xinyong SHEN Wei CHENG Haoxin YAO Ziniu XIAO | 2023 | Advances in Atmospheric Sciences2023，40，12： | 0 |
| 3 | Main environmental drivers of abundance,diversity and community structure of comammox Nitrospira in paddy soils显示文摘The recently discovered complete ammonia oxidizers comammox Nitrospira contain clades A and B that can establish an independent one-step nitrification process;however,little is known about their environmental drivers or habitat distributions in agricultural soils.Previous studies on comammox Nitrospira in paddy soils have mainly focused on small-scale samples,and there is a lack of multisite research on comammox Nitrospira in paddy soils.In this study,we conducted a survey of 36 paddy soils to understand the community structure,abundance,and diversity of comammox Nitrospira and the degree to which they are affected by environmental factors at a large scale.Comammox Nitrospira were found to be widely distributed among the paddy soils.The abundance of comammox Nitrospira clade A was mostly lower than that of clade B,whereas its diversity was mostly higher than that of clade B.Correlation analysis showed that multiple factors affected(P<0.05)the abundance of comammox Nitrospira,including soil pH,organic matter,total carbon,and total nitrogen,latitude,mean annual temperature,and mean annual precipitation.Moreover,there was a clear relationship between the comammox Nitrospira community and habitat,indicating that some amplicon sequence variants(ASVs)had a unique dominant position in specific habitats.Phylogenetic analysis showed that the ASVs of comammox Nitrospira clade A clustered with the known sequences in the paddy soils and were significantly different from the known sequences in other habitats,which may be related to the unique paddy field habitat.In contrast,comammox Nitrospira clade B showed no clear habitat dependence.These results support the wide distribution and high abundance of comammox Nitrospira in paddy soils and provide novel insights into nitrogen cycling and nutrient management in agricultural ecosystems. | Fuyun GAO Yaying LI Haoxin FAN Jiantao XUE Huaiying YAO | 2023 | Pedosphere2023，33，5： | 0 |
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