2篇
您的检索式：作者名="Haolan Feng"
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| 1 | Dexamethasone-loaded ROS-responsive poly(thioketal)nanoparticles suppress inflammation and oxidative stress of acute lung injury显示文摘Acute lung injury(ALI)is associated with excessive inflammatory response,leading to acute respiratory distress syndrome(ARDS)without timely treatment.A fewer effective drugs are available currently to treat the ALI/ARDS.Herein,a therapeutic nanoplatform with reactive oxygen species(ROS)-responsiveness was developed for the regulation of inflammation.Dexamethasone acetate(Dex)was encapsulated into poly(thioketal)polymers to form polymeric nanoparticles(NPs)(PTKNPs@Dex).The NPs were composed of poly(1,4-phenyleneacetonedimethylene thioketal)(PPADT)and polythioketal urethane(PTKU),in which the thioketal bonds could be cleaved by the high level of ROS at the ALI site.The PTKNPs@Dex could accumulate in the pulmonary inflammatory sites and release the encapsulated payloads rapidly,leading to the decreased ROS level,less generation of pro-inflammatory cytokines,and reduced lung injury and mortality of mice.RNA sequencing(RNA-seq)analysis showed that the therapeutic efficacy of the NPs was associated with the modulation of many immune and inflammation-linked pathways.These findings provide a newly developed nanoplatform for the efficient treatment of ALI/ARDS. | Zihe Zhai Wei Ouyang Yuejun Yao Yuqi Zhang Haolan Zhang Feng Xu Changyou Gao | 2022 | Bioactive Materials2022，7，8： | 5 |
| 2 | Mechanism and preventive measures of slurry leakage at shield tail brushes under abnormal shutdown condition—A case study显示文摘Based on an underwater shield tunnel project,this study introduces the phenomenon of abnormal shutdown and the measures designed to mitigate problems in construction.On the strength of the analysis of the slurry leakage causes during re-tunneling,the mech-anism of slurry leakage induced by jack retraction was studied,and treatment measures of leakage at shield tail brushes were elaborated upon.The results show that the sudden change of stratum leads to an abnormal shutdown,and a sharp increase in the slurry pressure at the shield cut location leads to the slurry penetrating the gap between the outer wall of the shield shell and the soil,increasing the risk of instantaneous breakdown at shield tail brushes.The radial displacement of the outer wall of the segments caused by retractions of three jacks and a single jack along the circumferential direction distinctly shows three regions and four regions,respectively.The radial shrink-age of the outer wall of the segments at the jack retraction position decreases the tightness between the shield tail brushes and the outer wall of the segments.The expansion of the outer wall of the segments at the surrounding position,especially at the lower position,increases the slurry level to the radial shrinkage position of the segments,which increases the risk of slurry leakage.Furthermore,when the shield machine faces an abnormal shutdown,re-tunneling,and assembly of segments,the jack can be gradually retracted from top to bottom.The slurry leakage degree can be observed when retracting,and the corresponding measures can be taken for timely plugging.According to the leakage degree,it can be determined whether to replace the shield tail brushes to reduce the risk of large-scale leakage accidents. | Fei Ye Haolan Feng Xingbo Han Xiaoming Liang Haidong Sun Wenjun Zhang Xiaoyong Cao | 2023 | Underground Space2023，，1： | 0 |
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