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| 1 | Plasma D-dimer level in early and late-onset neonatal sepsis显示文摘BACKGROUND Neonatal sepsis is a life-threatening disease.Early diagnosis is essential,but no single marker of infection has been identified.Sepsis activates a coagulation cascade with simultaneous production of the D-dimers due to lysis of fibrin.Ddimer test reflects the activation of the coagulation system.AIM To assess the D-dimer plasma level,elaborating its clinicopathological value in neonates with early-onset and late-onset neonatal sepsis.METHODS The study was a prospective cross-sectional study that included ninety neonates;divided into three groups:Group I:Early-onset sepsis(EOS);Group II:Late-onset sepsis(LOS);and GroupⅢ:Control group.We diagnosed neonatal sepsis according to our protocol.C-reactive protein(CRP)and D-dimer assays were compared between EOS and LOS and correlated to the causative microbiological agents.RESULTS D-dimer was significantly higher in septic groups with a considerably higher number of cases with positive D-dimer.Neonates with LOS had substantially higher levels of D-dimer than EOS,with no significant differences in CRP.Neonates with LOS had a significantly longer hospitalization duration and higher gram-negative bacteriemia and mortality rates than EOS(P<0.01).Gramnegative bacteria have the highest D-dimer levels(Acinetobacter,Klebsiella,and Pseudomonas)and CRP(Serratia,Klebsiella,and Pseudomonas);while gram-positive sepsis was associated with relatively lower levels.D-dimer had a significant negative correlation with hemoglobin level and platelet count;and a significant positive correlation with CRP,hospitalization duration,and mortality rates.The best-suggested cut-off point for D-dimer in neonatal sepsis was 0.75 mg/L,giving a sensitivity of 72.7%and specificity of 86.7%.The D-dimer assay has specificity and sensitivity comparable to CRP in the current study.CONCLUSION The current study revealed a significant diagnostic value for D-dimer in neonatal sepsis.D-dimer can be used as an adjunct to other sepsis markers to increase the sensitivity and specificity of diagnosing neonatal sepsis. | Mohammed Al-Biltagi Ehab M Hantash Mohammed Ramadan El-Shanshory Enayat Aly Badr Mohamed Zahra Manar Hany Anwar | 2022 | World Journal of Critical Care Medicine2022，11，3： | 2 |
| 2 | TGF-betal regulates differentiation of t)one marrow mes- enchymal stem cells显示文摘 | Zhao L Hantash B M | 2011 | Vitam Horm2011，87，5： | 1 |
| 3 | Satisfaction with Dental Implants:A Literature Review显示文摘 | AL-Omiri Mahoud BDS PhD Hantash Ra'ed Abu BDS MDSc + AL-Wahadni Ahed BDS MDSc PhD ++ | 2005 | Implant Dentistry2005，14，4： | 1 |
| 4 | Advances in the treatment of melasma: a review of the recent literature 显示文摘 | Ball Arefiev KL Hantash BM | 2012 | Dermatol Surg2012，38，71： | 1 |
| 5 | Pilot clinical study of a novel minimally invasive bipolar microneedle radiofrequency device显示文摘 | Hantash BM Renton B Berkowitz RL | 2009 | Lasers Surg Med2009，41，2： | 1 |
| 6 | Bipolar fractional radiofrequency treatment induces neoelastogenesis and neocollagene- sis显示文摘 | Hantash BM Ubeid AA Chang H | 2009 | Lasers Surg Med2009，41，1： | 1 |
| 7 | Laser induced transepidermal elimination of dermal content by fractional photothermolysis显示文摘 | Hantash BM Bedi VP Sudireddy V | 2006 | J Biomed Opt2006，11，： | 1 |
| 8 | The expression and functional activity of membrane-bound human leukocyte antigen-G1 are influenced by the 3′-untranslated region显示文摘 | Signe Goul Svendsen Basil M. Hantash Longmei Zhao Carsten Faber Michael Bzorek Mogens Holst Nissen Thomas Vauvert F. Hviid | 2013 | Human Immunology2013，，7： | 1 |
| 9 | Bipolar fractional radiofrequency treatment induces neoelastogenesis and neocolla- genesis 显示文摘 | Hantash BM Ubeid AA Chang H | 2009 | Lasers Surg Med2009，41，1： | 1 |
| 10 | Use of an on-line imprinted polymer pre-column,for the liquid chromatographic-UV absorbance determination of carbaryl and its metabolite in complex matrices显示文摘 | Hantash J Bartlett A | 2006 | J Chromatogr A2006，1125，1： | 1 |
| 11 | Fractional photothermolysis: a novel aesthetic laser surgery modality 显示文摘 | Hantash BM Mahmood MB | 2007 | Dermatol Surg2007，33，5： | 1 |
| 12 | The expression and func- tional activity of membrane - bound human leukocyte antigen - G1 are influenced by the 3'-untranslated region显示文摘 | Svendsen SG Hantash BM Zhao L | 2013 | Hum Imnmnol2013，74，7： | 1 |
| 13 | Ex vivo histologi-cal characterization of a novel ablative fractional resurfacing device显示文摘 | HANTASH B M BEDIVP CHAN K F el al | 2007 | Laser & Surg Med2007，39，2： | 1 |
| 14 | Pharmacokinetics and bioavailability of doxycycline in ostriches(Struthio camelus)at two different dose rates显示文摘 | Abu-Basha E A Idkaidek N M Hantash T M | 2006 | J Vet Sci2006，7，4： | 1 |
| 15 | In vivo histological evaluation of a novel ablative fractional resurfacing device显示文摘 | HANTASH B M BEDI V P KAPADIA B | 2007 | Laser Surg Med2007，39，2： | 1 |
| 16 | Dry socket: frequency, clinical picture, and risk factors in a palestinian dental teaching center 显示文摘 | Abu Younis MH Abu Hantash RO | 2011 | Open Dent2011，7，5： | 1 |
| 17 | Dry socket: frequency, clinical picture, and risk factors in a palestinian dental teaching center 显示文摘 | Abu Younis MH Abu Hantash RO | 2011 | J Open Dent2011，7，5： | 1 |
| 18 | Laser-induced trans- epidermal elimination of dermal content by fractional photothermolysis 显示文摘 | Hantash BM Bedi VP Sudiredy V | 2006 | J Biomed Opt2006，11，： | 1 |
| 19 | Invivo histological evaluation of anovel ablative fractional resurfacing device显示文摘 | Hantash BM Bedi VP Kapadia B | | Iasers Sm''g Med0，39，2： | 1 |
| 20 | Adult and fetal wound healing显示文摘 | Hantash BM Zhao L Knowles JA | 2008 | Front Biosci2008，3，： | 1 |
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