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| 1 | Cementomimetics——constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides显示文摘Cementum is the outer-,mineralized-tissue covering the tooth root and an essential part of the system of periodontal tissue that anchors the tooth to the bone. Periodontal disease results from the destructive behavior of the host elicited by an infectious biofilm adhering to the tooth root and left untreated,may lead to tooth loss. We describe a novel protocol for identifying peptide sequences from native proteins with the potential to repair damaged dental tissues by controlling hydroxyapatite biomineralization. Using amelogenin as a case study and a bioinformatics scoring matrix,we identified regions within amelogenin that are shared with a set of hydroxyapatite-binding peptides (HABPs) previously selected by phage display. One 22-amino acid long peptide regions referred to as amelogenin-derived peptide 5 (ADP5) was shown to facilitate cell-free formation of a cementum-like hydroxyapatite mineral layer on demineralized human root dentin that,in turn,supported attachment of periodontal ligament cells in vitro. Our findings have several implications in peptide-assisted mineral formation that mimic biomineralization. By further elaborating the mechanism for protein control over the biomineral formed,we afford new insights into the evolution of protein-mineral interactions. By exploiting small peptide domains of native proteins,our understanding of structure-function relationships of biomineralizing proteins can be extended and these peptides can be utilized to engineer mineral formation. Finally,the cementomimetic layer formed by ADP5 has the potential clinical application to repair diseased root surfaces so as to promote the regeneration of periodontal tissues and thereby reduce the morbidity associated with tooth loss. | Mustafa Gungormus Ersin E Oren Jeremy A Horst Hanson Fong Marketa Hnilova Martha J Somerman Malcolm L Snead Ram Samudrala Candan Tamerler Mehmet Sarikaya | 2012 | International Journal of Oral Science2012，4，2： | 5 |
| 2 | Sib-pair linkage an alysis for susceptibility genes for microvascular complications among Pima India ns with type 2 diabetes显示文摘 | Imperatore G Hanson R L Pettitt D J | | 0，，： | 3 |
| 3 | Simultaneous determination of phenytoin,carbamazepine, and 10, 11 -carbamazepine epoxide in human plasma by high-performance liquid chromatography with ultraviolet detection显示文摘 | Bhatti MM Hanson GD Schultz L | 1998 | J Pharm Biomed Anal1998，16，： | 2 |
| 4 | Prokayotic osmoregulation:Genetics and physiology 显示文摘 | Csonka L N Hanson A D | 1991 | Annu Rev Microbiol1991，45，： | 1 |
| 5 | Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development显示文摘 | Hanson R D Hess J L Yu B D | 1999 | Proc Natl Acad Sci U S A1999，96，14： | 1 |
| 6 | Hospice attitudes among assisted living and nursing home administrators,and the long-term care hospice attitudes scale显示文摘 | Dobbs DJ Hanson L Zimmerman S | 2006 | J Palliat Med2006，9，6： | 1 |
| 7 | Development and testing of the questionnaire on perception of self-care agency 显示文摘 | Hanson B Bickel L | 1985 | Sci Art Self Care1985，，76： | 1 |
| 8 | De- velopment and Characterization of Soil Material Param- eters for Embankment Breach 显示文摘 | Hanson G J Temple D M Hunt S L Tejral R D | 2011 | Applied Engineer- ing in Agriculture2011，，4： | 1 |
| 9 | Plasmid-mediated, carbapenem-hydrolysing beta-lactamase, KPC-2, in Klebsiella pneumoniae isolates 显示文摘 | SMITH M E HANSON N D HERREEA V L | 2007 | Antimicrob Agents Chemother2007，51，2： | 1 |
| 10 | Current trcnds in Rwanda's HIV/AIDS epidemic显示文摘 | Kayirangwa E Hanson J Mlmyakazi L Kabeja A | 2006 | Sex Transm Infect2006，82，1： | 1 |
| 11 | Effects of threonine on growth and antibody production in chicks infected with Newcastle disease virus显示文摘 | Bhargava K K Hanson R P Sunde M L | 1971 | Poult Sci1971，50，： | 1 |
| 12 | Standardization of a fluconazole bioassay and correlation of results with those obtained by high-pressure liquid chromatography显示文摘 | REX J H HANSON L H AMANTEA M A | 1991 | Antimicrob Agents Chemother1991，35，： | 1 |
| 13 | Regulation of phosphoenolpyruvate carboxykinase ( GTP ) gene expression 显示文摘 | Hanson R W Reshef L | 1997 | Annu Rev Biochem1997，66，： | 1 |
| 14 | CollisionaI narrowing effects on spectral line shapes measured at high resolution显示文摘 | P L Varghese R K Hanson | 1984 | Appl Opt1984，23，14： | 1 |
| 15 | Implant-related complications in the treatment of unstable intertrochanteric fractures:meta-analysis of dynamic screw-plate versus dynamic screw-intramedullary nail devices显示文摘 | Andige L Hanson B Swiontkowski MF | | 0，，4： | 1 |
| 16 | Common polymorphisms in the adiponectin gene ACDC are not associated with diabetes in PimaIndians显示文摘 | Vozavova D E Courten B Hanson R L | 2005 | Diabetes2005，54，1： | 1 |
| 17 | Hematopoietic colony-forming cells derived from human embryonic stem cells显示文摘 | Kaufman DS Hanson ET Rachel L | 2001 | Proc Natl Acad Sci USA2001，98，10： | 1 |
| 18 | Implant-related complications in the treatment of unstable intertrochanteric fractures:meta-analysis of dynamic screw-plate versus dynamic screw intramedullary nail devices显示文摘 | Andige L Hanson B Swiontkowski MF | 2003 | Int Orthop2003，27，： | 1 |
| 19 | Basic linear algebra subprograms for Fortran usage显示文摘 | Lawson C L Hanson R J Kincaid D R | 1979 | ACM Transactions on Mathematical Software1979，5，3： | 1 |
| 20 | Evaluation of simple indices of insulin sensitivity and insulin secretion foruse in epidemi- ologic studies显示文摘 | Hanson R L Pratley R E Bogardus C | 2000 | Am J Epidemio2000，151，2： | 1 |
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