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| 1 | Middle Triassic post-orogenic extension on Hainan Island: Chronology and geochemistry constraints of bimodal intrusive rocks显示文摘This work studies new petrological and geochemical data and zircon U-Pb ages for bimodal intrusive rocks from Xinglong region, Hainan Island. Zircon U-Pb dating yields mean 238 U/ 206 Pb ages of 238 ± 2 Ma and 234 ± 2 Ma for diabasic and granitic phases, respectively, representing the Middle Triassic emplacement. The diabase and granite bodies were formed from discrete mafic and acidic magma sources that experienced local mechanical mixing at their mutual contacts. Although SiO 2 content of intrusions is bimodal, trace element ratios indicate that both were formed in a post-orogenic extensional setting. Sr-Nd isotopic composition reflects a shared EMII type enriched mantle source component, possibly influenced by subduction-fluid metasomatism. | TANG LiMei CHEN HanLin DONG ChuanWan YANG ShuFeng SHEN ZhongYue CHENG XiaoGan FU LuLu | 2013 | Science China Earth Sciences2013，56，5： | 12 |
| 2 | Standardized Operational Protocol for Human Brain Banking in China显示文摘With the progress of society, there is an increasing need to tackle disorders of the central nervous system. Human brain tissue, unlike animal tissues, is an irreplaceable resource for the study of neurological diseases (1)Aimed at scientific research and education, the roles of human brain tissue repositories are to acquire brain tissue from donors, prepare, process, and preserve collected samples,provide tissue to specific eligible facilities, and determine the characteristics of each tissue sample. | Wenying Qiu Hanlin Zhang Aimin Bao Keqing Zhu Yue Huang Xiaoxin Yan Jing Zhang Chunjiu Zhong Yong Shen Jiangning Zhou Xiaoying Zheng Liwei Zhang Yousheng Shu Beisha Tang Zhenxin Zhang Gang Wang Ren Zhou Bing Sun Changlin Gong Shumin Duan Chao Ma | 2019 | Neuroscience Bulletin2019，35，2： | 6 |
| 3 | LSTM-based argument recommendation for non-API methods显示文摘Automatic code completion is one of the most useful features provided by advanced IDEs.Argument recommendation,as a special kind of code completion,is widely used as well.While existing approaches focus on argument recommendation for popular APIs,a large number of non-API invocations are requesting for accurate argument recommendation as well.To this end,we propose an LSTM-based approach to recommending non-API arguments instantly when method calls are typed in.With data collected from a large corpus of open-source applications,we train an LSTM neural network to recommend actual arguments based on identifiers of the invoked method,the corresponding formal parameter,and a list of syntactically correct candidate arguments.To feed these identifiers into the LSTM neural network,we convert them into fixed-length vectors by Paragraph Vector,an unsupervised neural network based learning algorithm.With the resulting LSTM neural network trained on sample applications,for a given call site we can predict which of the candidate arguments is more likely to be the correct one.We evaluate the proposed approach with tenfold validation on 85 open-source C applications.Results suggest that the proposed approach outperforms the state-of-the-art approaches in recommending non-API arguments.It improves the precision significantly from 71.46%to 83.37%. | Guangjie LI Hui LIU Ge LI Sijie SHEN Hanlin TANG | 2020 | Science China(Information Sciences)2020，63，9： | 5 |
| 4 | Measurement of Neutron Capture Cross Section for ^(180)Hf | Chen Jinxiang Shi Zhaomin Tang Guoyou Zhang Guohui Institute of Heavy Ion Physics,Peking University,Beijing 100871Lu Hanlin Han Xiaogang Huang Xiaolong China Institute of Atomic Energy,P.O.Box 275(3),Beijing 102413 | 1997 | Chinese journal of nuclear physics1997，，2： | 3 |
| 5 | Effects of Xuebijing Combined with Ulinastatin on Coagulation Function of Sepsis Patients显示文摘[Objectives] To study the effects of Xuebijing combined with ulinastatin on coagulation function of sepsis patients. [Methods]Fifty six patients conforming to the diagnosis criteria for sepsis and receiving the treatment from May 2015 to January 2019 were selected. They were randomly divided into treatment group and control group according to the order of treatment. The two groups were treated according to the International Guidelines for Management of Severe Sepsis and Septic Shock( 2012),in which ulinastatin and Xuebijing were added to the treatment group. Before the treatment and on the seventh day after the treatment,both groups of patients were measured for the activated partial thromboplastin time( APTT),fibrinogen( Fi B),platelet( PLT),and prothrombin time( PT) were measured;the treatment status of the both groups was continuously observed for 7 d,and the mechanical ventilation time,ICU hospitalization time,and 30-day survival rate were recorded. [Results] Both FIB and PLT of the treatment group were significantly increased,and both APTT and PT were significantly shortened.Compared with the control group,the difference was statistically significant( P < 0. 05). The mechanical ventilation time and ICU hospitalization time of the treatment group were significantly shorter than that of the control group,and the 30-day survival rate of the treatment group was significantly higher than that of the control group,and the difference was statistically significant( P < 0. 05). [Conclusions]Xuebijing combined with ulinastatin can improve coagulation disorders of sepsis patients. | Yongping ZHANG Xuhong TAN Qin LI Hanlin TANG Zaiqun WANG Li XU | 2019 | Medicinal Plant2019，10，3： | 1 |
| 6 | Hedgehog pathway orchestrates the interplay of histone modifications and tailors combination epigenetic therapies in breast cancer显示文摘Epigenetic therapies that cause genome-wide epigenetic alterations,could trigger local interplay between different histone marks,leading to a switch of transcriptional outcome and therapeutic responses of epigenetic treatment.However,in human cancers with diverse oncogenic activation,how oncogenic pathways cooperate with epigenetic modifiers to regulate the histone mark interplay is poorly understood.We herein discover that the hedgehog(Hh)pathway reprograms the histone methylation landscape in breast cancer,especially in triple-negative breast cancer(TNBC).This facilitates the histone acetylation caused by histone deacetylase(HDAC)inhibitors and gives rise to new therapeutic vulnerability of combination therapies.Specifically,overexpression of zinc finger protein of the cerebellum 1(ZIC1)in breast cancer promotes Hh activation,facilitating the switch of H3K27 methylation(H3K27me)to acetylation(H3K27ac).The mutually exclusive relationship of H3K27me and H3K27ac allows their functional interplay at oncogenic gene locus and switches therapeutic outcomes.Using multiple in vivo breast cancer models including patient-derived TNBC xenograft,we show that Hh signaling-orchestrated H3K27me and H3K27ac interplay tailors combination epigenetic drugs in treating breast cancer.Together,this study reveals the new role of Hh signaling-regulated histone modifications interplay in responding to HDAC inhibitors and suggests new epigenetically-targeted therapeutic solutions for treating TNBC. | Xiaomin Wang Jun Xu Yiming Sun Siyuwei Cao Hanlin Zeng Nan Jin Matthew Shou Shuai Tang Yi Chen Min Huang | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 1 |
| 7 | Coordinating Zirconium Nodes in Metal-Organic Framework with Trifluoroacetic Acid for Enhanced Lewis Acid Catalysis显示文摘Regulating Lewis acid sites with well-defined electronic state and steric environment is still challenging for achieving high catalytic efficiency.Here we show coordinating zirconium nodes in the typical metal-organic framework known as MOF-545 with the monocarboxylate modulators including trifluoroacetic acid(TFA)or benzoic acid(BA)over meso-tetra(4-carboxyphenyl)-porphine(H_(2)TCPP),denoted as MOF-545-TFA or MOF-545-BA.Impressively,MOF-545-TFA shows the significantly enhanced performance for the catalytic ring-opening reaction of various epoxides with alcohols and good recyclability at 40°C in respect with MOF-545-BA and ZrO_(2).This mainly originates from the stronger Lewis acidity and more active zirconium sites induced by the electron-withdrawing TFA,resulting in the increased ability for activation of epoxides.This modulation approach is promising for enlarging the toolbox to extend the MOFs-based Lewis acid catalysis. | WANG Wenyang LIU Hanlin YANG Caoyu FAN Ting CUI Chengqian LU Xiaoquan TANG Zhiyong LI Guodong | 2022 | Chemical Research in Chinese Universities2022，38，5： | 0 |
| 8 | 白血病抑制因子受体反馈上调介导乳腺癌对组蛋白去乙酰化酶抑制剂耐药显示文摘靶向肿瘤表观遗传调控是当前分子靶向抗肿瘤药物研发的重要方向。组蛋白去乙酰化酶(HDAC)抑制剂在表观遗传领域率先取得成功,多个抑制剂被批准上市,用于多种亚型血液肿瘤的临床治疗。 | Hanlin Zeng Jia Qu Nan Jin Jun Xu Chenchu Lin Yi Chen Xinying Yang Xiang He Shuai Tang Xiaojing Lan Xiaotong Yang Ziqi Chen 黄敏 丁健 耿美玉 | 2017 | 科学新闻2017，19，4： | 0 |
| 9 | Room-temperature multiple ligands-tailored SnO_(2) quantum dots endow in situ dual-interface binding for upscaling efficient perovskite photovoltaics with high V_(OC)显示文摘The benchmark tin oxide(SnO_(2))electron transporting layers(ETLs)have enabled remarkable progress in planar perovskite solar cell(PSCs).However,the energy loss is still a challenge due to the lack of“hidden interface”control.We report a novel ligand-tailored ultrafine SnO_(2) quantum dots(QDs)via a facile rapid room temperature synthesis.Importantly,the ligand-tailored SnO_(2) QDs ETL with multi-functional terminal groups in situ refines the buried interfaces with both the perovskite and transparent electrode via enhanced interface binding and perovskite passivation.These novel ETLs induce synergistic effects of physical and chemical interfacial modulation and preferred perovskite crystallization-directing,delivering reduced interface defects,suppressed non-radiative recombination and elongated charge carrier lifetime.Power conversion efficiency(PCE)of 23.02%(0.04 cm^(2))and 21.6%(0.98 cm^(2),V_(OC) loss:0.336 V)have been achieved for the blade-coated PSCs(1.54 eV E_(g))with our new ETLs,representing a record for SnO_(2) based blade-coated PSCs.Moreover,a substantially enhanced PCE(V_(OC))from 20.4%(1.15 V)to 22.8%(1.24 V,90 mV higher V_(OC),0.04 cm^(2) device)in the blade-coated 1.61 eV PSCs system,via replacing the benchmark commercial colloidal SnO_(2) with our new ETLs. | Zhiwei Ren Kuan Liu Hanlin Hu Xuyun Guo Yajun Gao Patrick W.K.Fong Qiong Liang Hua Tang Jiaming Huang Hengkai Zhang Minchao Qin Li Cui Hrisheekesh Thachoth Chandran Dong Shen Ming-Fai Lo Annie Ng Charles Surya Minhua Shao Chun-Sing Lee Xinhui Lu Frédéric Laquai Ye Zhu Gang Li | 2021 | Light(Science & Applications)2021，10，12： | 0 |
| 10 | Research status and hotspot analysis of body donation in China:A CiteSpace-based study显示文摘To provide references by analyzing the history,hotspot,and trend of the research in body donation,CiteSpace software was used to conduct a co occurrence network analysis,and 196 articles in CNKI database were included.With the increasing number of articles in recent years,“Political and legal organizations”and“medical schools and departments”were main research institutions. | Liu Runzhu Tang Keyun Lei Shubin Li Xianmei Zhang Hanlin Ma Chao | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 11 | Thermometric properties of Na_(2)Y_(2)TeB_(2)O_(10):Tb^(3+)green phosphor based on fluorescence/excitation intensity ratio显示文摘For noncontact optical thermometry,in contrast with fluorescence intensity ratio(FIR)technology,excitation intensity ratio(EIR)technology has been seriously limited due to low sensitivity.Moreover,by exploring all possible temperature-dependent response,developing multimode optical thermometry is of great importance.In this work,a new Na_(2)Y_(2)TeB_(2)O_(10):Tb^(3+)phosphor is obtained by a solid-state reaction.Based on FIR and EIR models of Tb',thermometric properties are studied thoroughly.Excellent relative and absolute sensitivity(S_(R)and S_(A))are acquired due to the significant difference in emission/excitation lines in response to temperature.Meanwhile,Tb^(3+)content-dependent luminescence quenching mechanism is discussed.This study shows a feasible route for exploiting well-performing FIR-/EIR-based thermometric materials. | Yuefei Xiang Lin Yang Canyuan Liao Xianfeng Xiang Xiangkai Tang Hanlin Tang Jing Zhu | 2023 | Journal of Advanced Ceramics2023，12，4： | 0 |
| 12 | Contributions of Chinese scholars to body donation research in international journals显示文摘Anatomical dissectionis an important part of human anatomy course and relies much on cadavers.Body donation is the primary source of cadavers used in ana tomical dissection course in China.This study aimed to systematically review the contributions of Chinese scholars to body donation research in international journals,in the 100^(th) anniversary of the foundation of Chinese Society for Anatomical Sciences.The search was conducted on May 12,2020.The searching strategy was(body or anatomy or anatomical or cadaver or cadaveric)and(donate or donation or bequest or gift or gifting)and(China or Hong Kong or Macao or Taiwan).Only English articles focusing on body donation research were included.A total of 578 articles were retrieved. | Zhang Hanlin Tang Keyun Hu Xinzhi Wang Yuanzhuo Liu Runzhu Ma Chao | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 13 | Federated Learning Model for Auto Insurance Rate Setting Based on Tweedie Distribution显示文摘In the assessment of car insurance claims,the claim rate for car insurance presents a highly skewed probability distribution,which is typically modeled using Tweedie distribution.The traditional approach to obtaining the Tweedie regression model involves training on a centralized dataset,when the data is provided by multiple parties,training a privacy-preserving Tweedie regression model without exchanging raw data becomes a challenge.To address this issue,this study introduces a novel vertical federated learning-based Tweedie regression algorithm for multi-party auto insurance rate setting in data silos.The algorithm can keep sensitive data locally and uses privacy-preserving techniques to achieve intersection operations between the two parties holding the data.After determining which entities are shared,the participants train the model locally using the shared entity data to obtain the local generalized linear model intermediate parameters.The homomorphic encryption algorithms are introduced to interact with and update the model intermediate parameters to collaboratively complete the joint training of the car insurance rate-setting model.Performance tests on two publicly available datasets show that the proposed federated Tweedie regression algorithm can effectively generate Tweedie regression models that leverage the value of data fromboth partieswithout exchanging data.The assessment results of the scheme approach those of the Tweedie regressionmodel learned fromcentralized data,and outperformthe Tweedie regressionmodel learned independently by a single party. | Tao Yin Changgen Peng Weijie Tan Dequan Xu Hanlin Tang | 2024 | Computer Modeling in Engineering & Sciences2024，138，1： | 0 |
| 14 | A novel formulation of bupivacaine-encapsulated PLGA nanoparticles in peripheral analgesia显示文摘Bupivacaine encapsulated poly(lactidecoglycolide)nanoparticles is a novel formulation of extended-release of bupivacaine in poly(lactidecoglycolide)matrix.We evaluated the efficacy and safety of bupivacaine nanoparticles in peripheral analgesia via behavior tests,electrophysiological recordings,pharmacokinetic analysis,and pathology staining by employing the models of uninjured rats and mice.Nanoparticles injection increased the pain thresholds of rats and mice for 21 days. | Wang Tao Tang Keyun Fang Yehong Zhang Hanlin Ma Chao | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 15 | Two bicistronic DNA vaccines against Vibrio anguillarum and the immune eff ects on flounder Paralichthys olivaceus显示文摘Chemokines are cytokines that can promote the activation and migration of immune cells,and increase the recognition of antigen by antigen-presenting cells(APC).Previous studies showed that a DNA vaccine can induce humoral and cellular immune responses of flounder after immunization.To explore the improvement of chemokines on the efficiency of OmpK vaccine,two bicistronic DNA candidate vaccines were constructed and the immune responses they induced in the flounder were investigated by reverse transcription polymerase chain reaction(RT-PCR),indirect immunofl uorescent assay(IFA),H&E staining,fl ow cytometry(FCM),and quantifi cational real-time polymerase chain reaction(qRT-PCR).pBudCE4.1 plasmid as an expression vector,bicistronic DNA vaccines encoding OmpK gene and CC-motif ligand 4 gene(p-OmpK-CCL4),or Ompk gene and CC-motif ligand 19 gene(p-OmpK-CCL19)were successfully constructed.The results showed that two bicistronic DNA vaccines expressed Ompk protein of Vibrio anguillarum and CCL4/CCL19 proteins of fl ounder both in vitro and in vivo.After immunization,a large number of leucocytes in muscle were recruited at the injection site in treatment groups.The constructed vaccines induced signifi cant increases in CD4-1^(+) and CD4-2^(+) T lymphocytes,and sIgM^(+) B lymphocytes in peripheral blood,spleen,and head kidney.The percentage of T lymphocytes peaked on the 14^(th) post-vaccination day whereas that of B lymphocytes peaked in the 6^(th) post-vaccination week.Moreover,the expression profi les of 10 immune-related genes increased in muscles around the injection site,spleen,and head kidney.After the challenge,p-OmpK-CCL4 and p-OmpK-CCL19 conferred a relative percentage survival(RPS)of 74.1%and 63.3%,respectively,higher than p-OmpK alone(40.8%).In conclusion,both CCL4 and CCL19 can improve the protection of p-OmpK via evoking local immune response and then humoral and cellular immunity.CCL4 and CCL19 will be potential molecular adjuvants for use in DNA vaccines. | Hanlin LI Jing XING Xiaoqian TANG Xiuzhen SHENG Heng CHI Wenbin ZHAN | 2022 | Journal of Oceanology and Limnology2022，40，2： | 0 |
| 16 | Efficient energy transfer in organic light-emitting transistor with tunable wavelength显示文摘Key challenges in the development of organic light-emitting transistors(OLETs)are blocking both scientific research and practical applications of these devices,e.g.,the absence of high-mobility emissive organic semiconductor materials,low device efficiency,and color tunability.Here,we report a novel device configuration called the energy transfer organic light-emitting transistor(ET-OLET)that is intended to overcome these challenges.An organic fluorescent dye-doped polymethyl methacrylate(PMMA)layer is inserted below the conventional high-mobility organic semiconductor layer in a single-component OLET to separate the functions of the charge transport and light-emitting layers,thus making the challenge to essentially integrate the high mobility and emissive functions within a single organic semiconductor in a conventional OLET or multilayer OLET unnecessary.In this architecture,there is little change in mobility,but the external quantum efficiency(EQE)of the ET-OLET is more than six times that of the conventional OLET because of the efficient Förster resonance energy transfer,which avoids exciton-charge annihilation.In addition,the emission color can be tuned from blue to white to green-yellow using the sourcedrain and gate voltages.The proposed structure is promising for use with electrically pumped organic lasers. | Ke Zhou Jian Tang Shaofan Fang Ke Jiang Fangxu Yang Deyang Ji Jing Xiang Jie Liu Huanli Dong(✉) Cheng Han Hanlin Hu Xiaotao Zhang Wenping Hu Yumeng Shi | 2022 | Nano Research2022，15，4： | 0 |
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