|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Stem cell therapy for the treatment of Leydig cell dysfunction in primary hypogonadism显示文摘The production of testosterone occurs within the Leydig cells of the testes. When production fails at this level from either congenital, acquired, or systemic disorders,the result is primary hypogonadism. While numerous testosterone formulations have been developed, none are yet fully capable of replicating the physiological patterns of testosterone secretion. Multiple stem cell therapies to restore androgenic function of the testes are under investigation. Leydig cells derived from bone marrow, adipose tissue, umbilical cord, and the testes have shown promise for future therapy for primary hypogonadism. In particular, the discovery and utilization of a group of progenitor stem cells within the testes, known as stem Leydig cells(SLCs), has led not only to a better understanding of testicular development, but of treatment as well. When combining this with an understanding of the mechanisms that lead to Leydig cell dysfunction, researchers and physicians will be able to develop stem cell therapies that target the specific step in the steroidogenic process that is deficient. The current preclinical studies highlight the complex nature of regenerating this steroidogenic process and the problems remain unresolved. In summary, there appears to be two current directions for stem cell therapy in male primary hypogonadism. The first method involves differentiating adult Leydig cells from stem cells of various origins from bone marrow, adipose, or embryonic sources. The second method involves isolating, identifying, and transplanting stem Leydig cells into testicular tissue. Theoretically, in-vivo re-activation of SLCs in men with primary hypogonadism due to age would be another alternative method to treat hypogonadism while eliminating the need for transplantation. | Taylor C Peak Nora M Haney William Wang Kenneth J DeLay Wayne J Hellstrom | 2016 | World Journal of Stem Cells2016，8，10： | 5 |
| 2 | Obesity and cardiometabolic disease risk factors among US adolescents with disabilities显示文摘AIM: To generate prevalence estimates of weight status and cardiometabolic disease risk factors among adolescents with and without disabilities.METHODS: Analysis of the 1999-2010 National Health and Nutrition Examination Survey data was conducted among 12-18 years old with(n = 256) and without disabilities(n = 5020). Mean values of waist circumference, fasting glucose, high-density-lipoprotein cholesterol, triglycerides, systolic and diastolic blood pressure and metabolic syndrome(Met S, ≥ 3 risk factors present) were examined by the following standardized body mass index(BMI) categories for those with and without disabilities; overweight(BMI ≥ 85th- < 95 th percentile for age and sex), obesity(BMI ≥ 95 th percentile) and severe obesity(BMI ≥35 kg/m2). Linear regression models were fit with each cardiometabolic disease risk factor independently as continuous outcomes to show relationships with disability status. RESULTS: Adolescents with disabilities were significantlymore likely to be overweight(49.3%), obese(27.6%) and severely obese(12%) vs their peers without disabilities(33.1%, 17.5% and 3.6%, respectively, P ≤ 0.01 for all). A higher proportion of overweight, obese and severely obese children with disabilities had abnormal SBP, fasting lipids and glucose as well as Met S(18.9% of overweight, 32.3% of obese, 55% of severely obese) vs their peers without disabilities(9.7%, 16.8%, 36.3%, respectively). US adolescents with disabilities are over three times as likely to have Met S(OR = 3.45, 95%CI: 1.08-10.99, P = 0.03) vs their peers with no disabilities.CONCLUSION: Results show that adolescents with disabilities are disproportionately affected by obesity and poor cardiometabolic health vs their peers with no disabilities. Health care professionals should monitor the cardiometabolic health of adolescents with disabilities. | Sarah E Messiah Denise C Vidot Gabriel Somarriba Kanathy Haney Semra Aytur Ruby A Natale Jeffrey P Brosco Kristopher L Arheart | 2015 | World Journal of Diabetes2015，6，1： | 2 |
| 3 | Flush of carbon dioxide following rewetting of dried soil relates to active organic pools显示文摘 | Franzluebbers A J Haney R L Honeycutt C W | 2000 | Soil Science Society of America Journal2000，64，2： | 1 |
| 4 | Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex显示文摘 | Brugnera E Haney L Grimsley C | | 0，，： | 1 |
| 5 | Necrotizing pancreatitis: diagnosis and management 显示文摘 | Haney J C Pappas T N | 2007 | Surg Clin North Am2007，87，： | 1 |
| 6 | Aqueous acrylicpolyurethane hybrid dispersions and their use in industrial coatings显示文摘 | HEGEDUS C R GILINSKIi A G HANEY R J | 1996 | Prog Org Coat Tech1996，68，852： | 1 |
| 7 | Timing of Labor Induction after Premature Rupture of Membranes between 32 and 36 Week's Gestation显示文摘 | Cravcllo C Haney EI | 1999 | Am J Obstet Gynecol1999，180，2： | 1 |
| 8 | Climatic influences on active fractions of soil organic matter显示文摘 | Franzluebbers A J Haney R L Honeycutt C W | 2001 | Soil Bi ology and Biochemistry2001，33，78： | 1 |
| 9 | Rural Hospital Nurse's Stressors and Coping Strategies:A Survey显示文摘 | LeSergent C M Haney C J | 2005 | Int J Nurs Stud2005，42，3： | 1 |
| 10 | Heterophilic binding of Ll on unmyelinated sensory axons mediates Schwarm cell adhesion and is required for axonal survival显示文摘 | Haney C Sahenk Z Li C | 1999 | J Cell Bioi1999，146，5： | 1 |
| 11 | Gastrointestinal bleeding due to vitamin K deficiency in patients on parenteral cefamandole 显示文摘 | HOOPER C A HANEY B B STONE H H | 1980 | Lancet1980，8158，1： | 1 |
| 12 | Developing a program to promote stress resilience and self-care in first-year medical students显示文摘 | Thomas S E Haney M K Pelic C M | | 0，，01： | 1 |
| 13 | Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex显示文摘 | Brugnera E Haney L Grimsley C | 2002 | Nat Cell Biol2002，4，8： | 1 |
| 14 | A 'systematic qualitative analysis of psychoeducational intervention for depression in patients with cancer显示文摘 | Barsevick AM Sweeney C Haney E et a/ | 2002 | Oncol Nurs Forum2002，29，1： | 1 |
| 15 | Climatic influences on active fraction s of soil organic matter 显示文摘 | Franzluebbers A J Haney R L Honeycutt C W | 2001 | Soil Biology& Biochemistry2001，33，78： | 1 |
| 16 | Rural hospital nurses's stressors and coping strategies: a survey显示文摘 | LESERGENT C M HANEY C J | 2005 | Int J Nurs Stud2005，42，3： | 1 |
| 17 | Inactivation of soybean trypsin inhibitors with ascorbic acid plus copper显示文摘 | Sessa D J Haney J K Nelsen T C | 1990 | Journal of agricultural and food chemistry1990，38，7： | 1 |
| 18 | Coping strategies for working women: aerobic exercise and relaxation intervention显示文摘 | Long B C Haney C J | 1988 | Behavior Therapy1988，19，： | 1 |
| 19 | Long-term follow-up of stressed women: a comparison of aerobic exercise and progressive relaxation显示文摘 | Long B C Haney C J | 1988 | Journal of Sport and Exercise Psychology1988，10，： | 1 |
| 20 | Enhancing physical activity in sedentary women : Aerobic exercise : Information, locus of control and attitudes 显示文摘 | Long B C Haney C J | 1986 | Journal of Sport Psychology1986，，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员