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| 1 | Plasma biomarker screening for liver fibrosis with the N-terminal isotope tagging strategy显示文摘A non-invasive diagnostic approach is crucial for the evaluation of severity of liver disease,treatment decisions,and assessing drug efficacy.This study evaluated plasma proteomic profiling via an N-terminal isotope tagging strategy coupled with liquid chromatography/Fourier transform ion cyclotron resonance mass spectrometry measurement to detect liver fibrosis staging.Pooled plasma from different liver fibrosis stages,which were assessed in advance by the current gold-standard of liver biopsy,was quantitatively analyzed.A total of 72 plasma proteins were found to be dysregulated during the fibrogenesis process,and this finding constituted a valuable candidate plasma biomarker bank for follow-up analysis.Validation results of fibronectin by Western blotting reconfirmed the mass-based data.Ingenuity Pathways Analysis showed four types of metabolic networks for the functional effect of liver fibrosis disease in chronic hepatitis B patients.Consequently,quantitative proteomics via the N-terminal acetyl isotope labeling technique provides an effective and useful tool for screening plasma candidate biomarkers for liver fibrosis.We quantitatively monitored the fibrogenesis process in CHB patients.We discovered many new valuable candidate biomarkers for the diagnosis of liver fibrosis and also partly identified the mechanism involved in liver fibrosis disease.These results provide a clearer understanding of liver fibrosis pathophysiology and will also hopefully lead to improvement of clinical diagnosis and treatment. | LI ShuLong LIU Xin WEI Lai WANG HuiFen ZHANG JiYang WEI HanDong QIAN XiaoHong JIANG Ying HE FuChu | 2011 | Science China(Life Sciences)2011，54，5： | 6 |
| 2 | Advances in MoS_2-Based Field Effect Transistors(FETs)显示文摘This paper reviews the original achievements and advances regarding the field effect transistor(FET) fabricated from one of the most studied transition metal dichalcogenides: two-dimensional Mo S2. Not like graphene, which is highlighted by a gapless Dirac cone band structure, Monolayer Mo S2 is featured with a 1.9 e V gapped direct energy band thus facilitates convenient electronic and/or optoelectronic modulation of its physical properties in FET structure. Indeed,many Mo S2 devices based on FET architecture such as phototransistors, memory devices, and sensors have been studied and extraordinary properties such as excellent mobility, ON/OFF ratio, and sensitivity of these devices have been exhibited. However, further developments in FET device applications depend a lot on if novel physics would be involved in them. In this review, an overview on advances and developments in the Mo S2-based FETs are presented. Engineering of Mo S2-based FETs will be discussed in details for understanding contact physics, formation of gate dielectric, and doping strategies. Also reported are demonstrations of device behaviors such as low-frequency noise and photoresponse in Mo S2-based FETs, which is crucial for developing electronic and optoelectronic devices. | Xin Tong Eric Ashalley Feng Lin Handong Li Zhiming M.Wang | 2015 | Nano-Micro Letters2015，7，3： | 6 |
| 3 | Ent-kaurane and ent-abietane diterpenoids from Isodon phyllostachys显示文摘Four new diterpenoids, phyllostachysins I–L(1–4), along with a known one, hebeiabinin B(5), were isolated from the aerial parts of Isodon phyllostachys(I. phyllostachys). Compounds 1 and 2 feature an ent-kaurane backbone, and 3, 4 and 5 bear an ent-abietane skeleton. Their structures were elucidated by means of spectroscopic analysis. Compounds 3 and 4 exhibited significant cytotoxic activity against human tumor cell lines(HL-60, SMMC-7721, A-549, MCF-7 and SW-480), and strongly inhibited NO production in LPS-stimulated RAW264.7 cells. | Jin Yang Yaqi An Haiyan Wu Miao Liu Weiguang Wang Xue Du Yan Li Jianxin Pu Handong Sun | 2016 | Science China Chemistry2016，59，9： | 2 |
| 4 | How many probe vehicles are enough for identifying traffic congestion? a study from a streaming data perspective显示文摘许多研究用车辆轨道被执行了例如,分析交通条件识别交通拥挤。然而,有探查车辆和他们的采样间隔的适当数字上的系统的研究的缺乏以便精确地识别交通拥挤。而且,大多数相关研究忽略轨道数据的流的特征。这份报纸首先代表就车辆轨道的溪流特征而言识别交通拥挤的一个新奇方法。而不是处理整个数据溪流,一系列快照被提取。拥挤的道路片断能被在一系列邻近的快照之中分析簇的进化识别。我们然后计算了一系列参数和他们的相应拥挤鉴定精确性。结果为相关探查车辆推广和交通分析有含意;例如,当 5% 探查车辆是可得到的时,如果采样时间间隔是 10 s. , 85% 鉴定精确性能被到达[出版摘要] | Handong WANG | 2013 | Frontiers of Earth Science2013，7，1： | 2 |
| 5 | Effect of photoionisation on initial discharge in air under nanosecond pulse voltage显示文摘Effects of photoionisation on the development and electron runaway of the initial discharge in atmospheric air under nanosecond pulse voltage were studied via twodimensional particle-in-cell/Monte Carlo collision simulations.It was found that photoionisation has little effect at the beginning of the initial discharge.However,as the discharge channel gradually develops towards the anode,photoionisation shows greater impacts on the morphology of discharge but has little influence on the velocity of discharge development.Photoionisation does not appear to have a decisive effect on the growth trend of the highest energy of runaway electrons,but it does affect the change rate of the highest energy and overall distribution of electron energy,resulting in a higher proportion of energetic electrons.The difference in the distributions of the electron energy between the two cases,with and without considering photoionisation,can be attributed to the impact of photoionisation on the discharge morphology,which in turn distorted the electric field.The spatial density distributions of the electrons produced by photoionisation further explained the differences.The authors’results explicitly demonstrate the influence of photoionisation on the development and the electron runaway of the initial discharge under nanosecond pulse voltage,which provides more comprehensive knowledge for the atmospheric air gap nanosecond pulse discharge physics. | Yutai Li Yangyang Fu Zhigang Liu Handong Li Peng Wang Haiyun Luo Xiaobing Zou Xinxin Wang | 2023 | High Voltage2023，8，2： | 2 |
| 6 | Improving flesh quality of grass carp(Ctenopharyngodon idellus)by completely replacing dietary soybean meal with yellow mealworm(Tenebrio molitor)显示文摘In order to find viable alternative protein sources for aquaculture,we evaluated the effect of partial or complete replacement of dietary soybean meal with yellow mealworm(TM)on the flesh quality of grass carp.In this study,180 grass carp(511.85±0.25 g)were fed 3 experimental diets in which 0%(CN),30%(YM30)and 100%(YM100)dietary soybean meal was replaced by TM for 90 d.The results showed that growth performance,biological parameters and serum antioxidant capacity of grass carp were not affected by dietary TM(P>0.05).Both muscle and whole body crude protein were obviously promoted with the increase of dietary TM(P<0.05),and the concentration of heavy metal in muscle was not influenced(P>0.05),indicating that food safety was not influenced by TM.Dietary TM improved muscle textural characteristics by elevating adhesiveness,springiness and chewiness in YM100(P<0.05).In addition,the muscle tenderness was significantly increased by declining the shear force(P<0.05).The muscle fiber density in YM30&YM100 and length of dark bands and sarcomeres in YM100 were obviously increased(P<0.05).The expression of myf5,myog and myhc exhibited a significant upward trend with the increase of dietary TM(P<0.05),which promoted fiber density,length of sarcomere and texture of grass carp muscle.According to the results of metabolomics,the arachidonate(ARA)and eicosapentaenoic acid(EPA)were notably elevated in YM30 and YM100,which indicated that the improvement of flesh quality of grass carp may contribute to the dietary TM influence on muscle lipid metabolism,especially the polyunsaturated fatty acids.In conclusion,TM can completely replace dietary soybean meal and improve the nutritional value of grass carp. | Handong Li Rongrong Xue Jian Sun Hong Ji | 2023 | Animal Nutrition2023，，1： | 2 |
| 7 | A rapid-response,high-sensitivity nanophase humidity sensor for respiratory monitoring 显示文摘 | Kalkan A K Li Handong O'Brien C J | 2004 | Electron Device Letters IEEE2004，25，8： | 1 |
| 8 | A series of meso-tris (N-methyl-pyridiniumyl)-(4-alkylamidophenyl) porphyrins:Synthesis,interaction with DNA and antibacterial activity显示文摘 | Fedorova O S Grachev AN | 1997 | Biochimica et Biophysica Acta1997，1354，： | 1 |
| 9 | Identification of volatile compounds of Atractylode lancea Rhizoma using supereritieal fluid extraction and GC-MS显示文摘 | Chen QinHua Li Peng Yang HanDong | 2009 | J Sep Sei2009，32，18： | 1 |
| 10 | Integrated supersonic wind tunnel nozzle显示文摘In supersonic wind tunnels, the airflow at the exit of a convergent-divergent nozzle is affected by the connection between the nozzle and test section, because the connection is a source of disturbance for supersonic flow and the source of disturbance generated by this disturbance propagates downstream. In order to avoid the disturbance, the test can only be carried out in the rhombus area. However, for the supersonic nozzle, the rhombus region is small, limiting the size and attitude angle of the test model. An integrated supersonic nozzle is a nozzle and a test section as a whole, which is designed to weaken or eliminate the disturbance. The inviscid contour of the supersonic nozzle is based on the method of characteristics. A new curve is formed by the smooth connection between the inviscid contour and test section, and the boundary layer is corrected for the overall curve. Integrated supersonic nozzles with Mach number 1.5 and 2 are designed, which are based on this method. The flow field is validated by numerical and experimental results. The results of the study highlight the importance of the connection about the nozzle outlet and test section. They clearly show that the wave system does not exist at the exit of the supersonic nozzle, and the flow field is uniform throughout the test section. | Junmou SHEN Jingang DONG Ruiqu LI Jiang ZHANG Xing CHEN Yongming QIN Handong MA | 2019 | Chinese Journal of Aeronautics2019，32，11： | 1 |
| 11 | Epitaxial growth and thermal-conductivity limit of singlecrystalline Bi2Se3/In2Se3 superlattices on mica显示文摘在超点阵的热运输被各种各样的散布声子的过程管理。为在 chalcogenide 超点阵提取异种接口的散布声子的贡献,单人赛水晶的双性人 2 Se 3/In2 有最小化的缺点的 Se 3(BS/IS ) 超点阵被分子的横梁取向附生在 fluorophlogopite 云母上准备。BS/IS 超点阵的跨飞机的进行热的性质被表明精确取决于时期厚度和超点阵的成分,在在热传导性的最小显示一条转线路从的地方对在超点阵的像波浪的声子运输像粒子。BS/IS 超点阵的热传导性的最小比内在的 BS 电影的低将近一个数量级。 | Wuyang Ren Handong Li Lei Gao Yong Li Zhongyang Zhang Chengjia Long Haining Ji Xiaobin Niu Yuan Lin Zhiming Wang | 2017 | Nano Research2017，10，1： | 1 |
| 12 | Effect of total phenolics from Laggera alata on acute and chronic inflammation models显示文摘 | Yihang Wu Changxin Zhou Liyan Song Xiangping Li Shuyun Shi Jianxia Mo Haiyong Chen Hua Bai Xiumei Wu Jun Zhao Rongping Zhang Xiaojiang Hao Handong Sun Yu Zhao | 2006 | Journal of Ethnopharmacology2006，，2： | 1 |
| 13 | Al homogeneous deposition induced by N-containing functional groups for enhanced cycling stability of Al-ion battery negative electrode显示文摘Rechargeable Al-ion batteries(AIBs)are considered as one of the most fascinating energy storage systems due to abundant Al resource and low cost.However,the cycling stability is subjected to critical problems for using Al foil as negative electrode,including Al dendrites,corrosion and pulverization.For addressing these problems,here a lightweight self-supporting N-doped carbon rod array(NCRA)is demonstrated for a long-life negative electrode in AIBs.Experimental analysis and first-principle calculations reveal the storage mechanism involving the induced deposition of N-containing function groups to Al as well as the ideal skeleton of the NCRA matrix for Al plating/stripping,which is favorable for regulating Al nucleation and suppressing dendrites growth.Compared with the Al foil,the NCRA exhibits lower areal mass density(∼72%of Al foil),smaller thickness(40%of Al foil),but much longer cycle life(>4 times of Al foil).Benefiting from the remarkable stability of the array structure,symmetric cells show excellent cycling stability with small voltage hysteresis(∼80 mV)and meanwhile there are no corrosion and pulverization problems even after cycled for 120 hours.Besides,full cells also manifest long lifespan(1,500 cycles)and increased Coulombic efficiency(100±1%). | Handong Jiao Shuqiang Jiao Wei-Li Song Xiang Xiao Dongmei She Na Li Haosen Chen Jiguo Tu Mingyong Wang Daining Fang | 2021 | Nano Research2021，14，3： | 1 |
| 14 | Mechanisms of antinociceptive effects of ouabain in combination with neostigmine in the rat显示文摘BACKGROUND: It has been previously shown that intrathecal administration of either ouabain or neostigmine can produce antinociceptive effects. Moreover, ouabain and neostigmine are differently associated with acetylcholine. OBJECTIVE: It has been hypothesized that intrathecal administration of ouabain, in combination with neostigmine, can produce antinociceptive synergistic effects. Atropine, as a competitive antagonist, was pre-injected to verify the mechanisms of action. DESIGN, TIME AND SETTING: This study was a randomized, controlled, animal experiment, performed at the State Key Laboratory of Oncology in Southern China between May 2006 and February 2007. MATERIALS: A total of 102 healthy, adult, Sprague Dawley rats were included. Ouabain and neostigmine (Sigma, USA), as well as atropine (Tanabe Seiyaku, Japan), were also used. METHODS: Varied doses of ouabain, neostigmine, and a combination of the two were intrathecally injected into rats. Six rats were allotted for each dose group. Intrathecal pretreatment with atropine was tested 10 minutes prior to intrathecal administration of neostigmine or the combination of ouabain and neostigmine. MAIN OUTCOME MEASURES: Tail-flick tests were performed to measure tail-flick latency (seconds) prior to and after administration. The response in the tail-flick test was expressed as the percentage of maximum possible effect (% MPE), where % MPE = [tail-flick latency after administration (seconds) -mean baseline value for tail-flick latency]/[10 seconds - the mean baseline value for tail-flick latency (seconds)] × 100%. RESULTS: Rat spinal intrathecal administration of either ouabain or neostigmine alone produced antinociceptive effects in a dose-dependent manner. Intrathecally administration of neostigmine (0.05, 0.1, 0.3 μg ) in combination with ouabain (1 μg ) produced enhanced antinociceptive effects, with a % MPE of 29%, 78%, and 95%, respectively (P < 0.05). Intrathecally administration of 0.3 μg neostigmine (% MPE: 45%), in combination with 1 μg ouabain (% MPE: 27%) produced potent antinociceptive effects (% MPE: 95%). Intrathecally pre-injected atropine antagonized the antinociceptive effects of neostigmine (3 μg), or a combination of ouabain (1 μg) and neostigmine (0.3 μg) (P < 0.01). CONCLUSION: Rat spinal intrathecal administration of either ouabain or neostigmine alone produced dose-dependent antinociceptive effects. Ouabain enhanced the antinociceptive effects of neostigmine. Atropine antagonized the antinociceptive effects of neostigmine or the combination of ouabain and neostigmine. This occurs possibly due to the fact that atropine is a competitive antagonist of the muscarinic acetylcholine receptors. | Handong Ouyang Qiang Li Weian Zeng Weixiong He Peizong Wang | 2008 | Neural Regeneration Research2008，3，7： | 1 |
| 15 | Anomalous phenomena in DC–ULF geomagnetic daily variation registered three days before the 12 May 2008 Wenchuan M_S 8.0 earthquake显示文摘The hourly data of the vertical Z and the horizontal H components of 37 ground-based DC-ULF geomagnetic stations are examined during 20 April-12 May 2008. On 9 May 2008, three days before the Wenchuan MS 8.0 shock, anomalies-a double low-point and a decreased amplitude-are registered on the curves of the Z component at 25 stations in a large-scale area surrounding the Wenchuan epicentral area. The H component shows none of the double low-point phenomenon but does exhibit a reduced magnitude at the same time. The geomagnetic index Kp is also examined and indicates that the anomalies appear at a solar quiet period. The appearing time shift(Tzs) between the first low-point on May 9 and the minimum point occurring time of May 1-5, 2008 is also checked.The results show that Tzs is on the order of 1-2 hours earlier or later than usual and there is a 2-6 hours’ gap between these two lowpoints. However, there is still a transition area which includes the epicenter where Tzs=0. Variation amplitude examined on vertical Z increases as the distance from the epicenter decreases. An Earth-air-ionosphere model has been employed to investigate a possible mechanism of this phenomenon and positive results have been unexpectedly attained. All these above-related results tend to prove that the variations of the Z and H on May 9, 2008 during the solar quiet period are probably associated with the forthcoming Wenchuan MS 8.0 earthquake. | Mei Li Li Yao YaLi Wang Michel Parrot Masashi Hayakawa Jun Lu HanDong Tan Tao Xie | 2019 | Earth and Planetary Physics2019，3，4： | 1 |
| 16 | Bismuth telluride nanostructures: preparation, thermoelectric properties and topological insulating effect显示文摘 | Eric ASHALLEY Haiyuan CHEN Xin TONG Handong LI Zhiming M. WANG | 2015 | Frontiers of Materials Science2015，9，2： | 1 |
| 17 | Alternations in the gut microbiota and metabolome with newly diagnosed unstable angina显示文摘Gut microbiota plays an important role in coronary heart disease, but its compositional and functional changes in unstable angina(UA) remain unexplored. We performed metagenomic sequencing of 133 newly diagnosed UA patients and 133 sex-and age-matched controls, and profiled the fecal and plasma metabolomes in 30 case-control pairs. The alpha diversity of gut microbiota was increased in UA patients:the adjusted odds ratios(ORs) per standard deviation increase in Shannon and Simpson indices were 1.30(95% confidence interval, 1.01-1.70) and 1.36(1.05-1.81), respectively. Two common species(depleted Klebsiella pneumoniae and enriched Streptococcus parasanguinis;P ≤ 0.002) and three rare species(depleted Weissella confusa, enriched Granulicatella adiacens and Erysipelotrichaceae bacterium 6_1_45;P ≤ 0.005) were associated with UA. The UA-associated gut microbiota was depleted in the pathway of Lphenylalanine degradation(P = 0.001), primarily contributed by Klebsiella pneumoniae. Consistently, we found increased circulating phenylalanine in UA patients(OR = 2.76 [1.17-8.16]). Moreover, Streptococcus parasanguinis was negatively correlated with fecal citrulline(Spearman's r_(s)=-0.470, P = 0.009), a metabolite depleted in UA patients(OR = 0.26 [0.08-0.63]). These findings are informative to help understand the metabolic connection between gut microbiota and UA. | Xuezhen Liu Miaoyan Shen Han Yan Pinpin Long Haijing Jiang Yizhi Zhang Lue Zhou Kuai Yu Gaokun Qiu Handong Yang Xiulou Li Xinwen Min Meian He Xiaomin Zhang Hyungwon Choi Chaolong Wang Tangchun Wu | 2022 | Journal of Genetics and Genomics2022，49，3： | 1 |
| 18 | To identify Chinese university patents'transferability:Indicators from the perspective of bibliometrics显示文摘It is of great significance to study the indicators of university patents’transferability for improving the efficiency of the University Technology Transfer Office and promoting university patent transfer.Based on the in-depth analysis of the existing research,this paper finds that patent quality is the inherent decisive factor of patent transferability.Combining with the evaluation indexes of patent quality and the bibliometrics characteristics of university patents,9 indicators are proposed to indicate the transferability of university patents.Based on the patent transfer data of 35 Chinese universities,this paper analyzes and verifies the potential indicators of patent transfer using the binary logistic regression method.The results show that the number of inventors and the number of non-patent document citations positively predict the transferability of university patents,while the examination duration negatively predicts transferability.The effects of other indicators on transferability need to be discussed considering the actual situation and specific technology fields. | Handong Zhang Rui Li Binhua Fu Qunying Wu | 2022 | Data Science and Informetrics2022，2，1： | 1 |
| 19 | Nanocrytalline Silicon thin film with arrayed void -column network deposited by high density plasma 显示文摘 | Sanghoon Bae Li Handong | 2000 | J Appl Phys2000，88，1： | 1 |
| 20 | Electronic structure and linear optical properties of YAl3 ( BO3 ) 4 显示文摘 | Wang Yuhua Wang Lingli Li Handong | 2007 | Journal of Applied Physics2007，102，01： | 1 |
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