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| 1 | Clinical decision support for drug related events: Moving towards better prevention显示文摘Clinical decision support(CDS) systems with automated alerts integrated into electronic medical records demonstrate efficacy for detecting medication errors(ME) and adverse drug events(ADEs). Critically ill patients are at increased risk for ME, ADEs and serious negative outcomes related to these events. Capitalizing on CDS to detect ME and prevent adverse drug related events has the potential to improve patient outcomes. The key to an effective medication safety surveillance system incorporating CDS is advancing the signals for alerts by using trajectory analyses to predict clinical events, instead of waiting for these events to occur. Additionally, incorporating cutting-edge biomarkers into alert knowledge in an effort to identify the need to adjust medication therapy portending harm will advance the current state of CDS. CDS can be taken a step further to identify drug related physiological events, which are less commonly included in surveillance systems. Predictive models for adverse events that combine patient factors with laboratory values and biomarkers are being established and these models can be the foundation for individualized CDS alerts to prevent impending ADEs. | Sandra L Kane-Gill Archita Achanta John A Kellum Steven M Handler | 2016 | World Journal of Critical Care Medicine2016，5，4： | 2 |
| 2 | Use of the piggyBac transposon for germline transformation of insects 显示文摘 | Handler A M | 2002 | Insect Biochemistry and Molecular Biology2002，32，： | 1 |
| 3 | Use of the piggyBac tmnsposon for germ-line transformation of insects 显示文摘 | HANDLER A M | 2002 | Insect Biochemistry and Molecular Bidogy2002，32，10： | 1 |
| 4 | Antioxidant,prooxidant and cytotoxic activity of hydroxylated resveratrol analogues:structure-activity relationship显示文摘 | Murias M Jager W Handler N | 2005 | Biochem Pharmacol2005，69，6： | 1 |
| 5 | A simple method for the precise determination of ≥ 40 trace elements in geological samples by ICPMS using enriched isotope internal standardisafion显示文摘 | Eggins S M Woodhead J D Kinsley L P J Mortimer G E Sylvester P McCulloch M T Hergt J M Handler M R | 1997 | Chem Geol1997，134，4： | 1 |
| 6 | The lepidopter an transposon vector, piggyBac, mediates germline transforma- tion in the Mediterranean fruitfly 显示文摘 | Handler A M McCombs S D Fraser M J | 1998 | Proe Natl Aead Sei USA1998，95，13： | 1 |
| 7 | The lepidopteran transposon vector,piggyBac ,mediates germ-line transformation in the Med- iterranean fruit fly 显示文摘 | HANDLER A M MCCOMBS S D FRASER M J | 1998 | Science Geneties1998，195，： | 1 |
| 8 | Germline transponmation of Drosophilia melanogaster with the piggyBac transposon vector显示文摘 | HANDLER A M HARRELL II R A | 1999 | Insect Mol Biol1999，8，4： | 1 |
| 9 | Antioxidant,prooxidant and cytotoxic activity of hydroxylated resveratrol analogues: structure-activity relationship 显示文摘 | Mu rias M Jager W Handler N | 2005 | Bioehem Pharmacol2005，69，6： | 1 |
| 10 | Resveratrol ana- logues as selective cyclooxygenase-2 inhibitors: synthesis and structure activity relationship 显示文摘 | MURIAS M HANDLER N ERKER T | 2004 | BioorgMed Chem2004，12，21： | 1 |
| 11 | Resveratrol analogues as selective cyclooxygenase-2 inhibitors:synthesis and structure-activity relationship显示文摘 | MURIAS M HANDLER N ERKER T | 2004 | Bioorg Med Chem2004，12，21： | 1 |
| 12 | Epidemiol- ogy of medication-related adverse events in nursing homes 显示文摘 | HANDLER S M WRIGHT R M RUBY C M | 2006 | Am J C eriatr Pharmacother2006，4，3： | 1 |
| 13 | Presenilin-1 regulates neuronal differentiation during neurogenesis 显示文摘 | Handler M Yang X Shen J | 2000 | Development2000，127，2： | 1 |
| 14 | A stable genomic source of P element transposase in drosophila melanogaster and related drosophilids显示文摘 | Sheliachu P Gomez Alfres M Handler | 1991 | Mol gen genet1991，，225： | 1 |
| 15 | Behavior of platinum group elements in the subcontinental mantle of eastern Australia during variable metasomatism and melt depletion显示文摘 | HANDLER M R BENNETT V C | 1999 | Geochim Cosmochim Acta1999，63，： | 1 |
| 16 | Highly similar piggyBae elements in Bactrocera that share a common lineage with elements in noctuid moths 显示文摘 | Handler A M Zimowska G J Armstrong K F | 2008 | Insect Molecular Biology2008，17，4： | 1 |
| 17 | Proterozoic lithosphere in Marie Byrd Land,West Antarctica:Re-Os systematics of spinel peridotite xenoliths显示文摘 | Wysoczanski R J Gamble J A | 2003 | Chemical Geology2003，196，： | 1 |
| 18 | Antioxidant,pro- oxidant and cytotoxic activity of hydroxylated resveratrol ana- logues: structure-activity relationship 显示文摘 | MURIAS M JAGER W HANDLER N | 2005 | Biochem Pharmacol2005，69，6： | 1 |
| 19 | Intracranial germ cell tumors:a single institution experience and review of the literature显示文摘 | SMITH A A WENG E HANDLER M | 2004 | J Neurooncol2004，68，2： | 1 |
| 20 | Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo 显示文摘 | Sharma B Handler M Eichstetter I | 1998 | J Clin Invest1998，102，8： | 1 |
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