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| 1 | Mitochondrial DNA from hepatocytes as a ligand for TLR9: Drivers of nonalcoholic steatohepatitis?显示文摘Nonalcoholic fatty liver disease(NAFLD) is the most common liver disease worldwide, affecting approximately one third of the Western world. It consists of a wide spectrum of liver disorders, ranging from fatty liver to nonalcoholic steatohepatitis(NASH), which consists of steatosis, ballooning injury and inflammation. Despite an alarming growth in the statistics surrounding NAFLD, there are as yet no effective therapies for its treatment. Innate immune signaling has been thought to play a significant role in initiating and augmenting hepatic inflammation, contributing to the transition from nonalcoholic fatty liver to NASH. An immune response is triggered by countless signals called damage-associated molecular patterns(DAMPs) elicited by lipid-laden and damaged hepatocytes, which are recognized by pattern recognition receptors(PRRs) on hepatic immune cells to initiate inflammatory signaling. In this editorial, in addition to summarizing innate immune signaling in NAFLD and discussing potential therapies that target innate immune pathways, we have described a recent study that demonstrated that mitochondrial DNA serves as a DAMP activating a hepatic PRR, TLR9, in mice and in the plasma of NASH patients. In addition to identifying a new ligand for TLR9 during NASH progression, the study shows that blocking TLR9 reverses NASH, paving the way for the development of future NASH therapy. | Priya Handa Akhila Vemulakonda Kris V Kowdley Misael Uribe Nahum Méndez-Sánchez | 2016 | World Journal of Gastroenterology2016，22，31： | 3 |
| 2 | Psychiatric morbidity in pemphigus and psoriasis :A comparative study from India显示文摘 | Kumar V Mattoo SK Handa S | 2013 | Asian J Psychiatr2013，6，2： | 1 |
| 3 | Vaginal childbirth and pelvic floor disorders 显示文摘 | MEMON H U HANDA V L | 2013 | Women''s Health ( London England)2013，9，3： | 1 |
| 4 | Simulators and virtual reality in surgical education显示文摘 | Chou B Handa V L | 2006 | Obstet Gynecol Clin North Am2006，33，2： | 1 |
| 5 | Bearing capacity of foot- ings adjacent to slopes显示文摘 | SWAMI S SUD V K HANDA S C | 1989 | Journal of Geotechnieal Engineer ing ASCE1989，115，4： | 1 |
| 6 | Female sexual function and pelvic floor disorders显示文摘 | Handa V L Cundiff G Chang H H | 2008 | Obstet Gynecol2008，111，5： | 1 |
| 7 | Sjogren's syndrome presenting with interstitial lung disease 显示文摘 | MARWAHA V MOHAPATRA S HANDA R | 2005 | J Assoc Physicians India2005，53，： | 1 |
| 8 | Bearing capacity of footings adjacent to slopes显示文摘 | SARAN S SUD V K HANDA S C | 1989 | Journal of Geoteehnical Engineering ASCE1989，115，4： | 1 |
| 9 | Bearing Capacity of Footings Adjacent to Slopes 显示文摘 | SARAN S SUD V K HANDA S C | 1989 | Journal of Geotechnical Engineering1989，115，4： | 1 |
| 10 | Protecting the pelvic floor: obstetric management to prevent incontinence and pelvic organ prolapse 显示文摘 | Handa V L Harris T A Ostergard D R | 1996 | Obstet Gnecol1996，88，3： | 1 |
| 11 | Bearing capacity of footings adjacent to slopes显示文摘 | SARAN S SUD V K HANDA S C | 1989 | Journal of Geotechnical Engineering1989，115，4： | 1 |
| 12 | Bcl-2 and c-myc expression, cell cycle kinetics and apoptosis during the progression of chronic myelogenous leukemia from diagnosis to blastic phase显示文摘 | Handa H Hegde U P Kotelnikov V M | 1997 | Leukemia Researsh1997，21，： | 1 |
| 13 | Outcome of valve repair and cox maze procedure for mitrial regurgitation and associated atrial fibrillation显示文摘 | SCHAFFf H V MORRIS J J | 1999 | J Thorac Cardiovasc Surg1999，118，4： | 1 |
| 14 | Slrena of frozen sand containing tetrahydrofuran hydrate显示文摘 | PARAMESWARAN V R PARADIS M HANDA Y P | 1989 | Canadian Geotectmical Journal1989，26，3： | 1 |
| 15 | Sexual function 6 months after first delivery显示文摘 | Bruhaker L Handa V L Bradley C S | 2008 | Obstet Gynecol2008，111，5： | 1 |
| 16 | Strength of fro-zen sand containing tetrahydrofuran hydrate显示文摘 | Parameswaran V R Paradis M Handa Y P | 1989 | CanadianGeotechnical Journal1989，26，3： | 1 |
| 17 | Vaginal childbirth and pelvic floor disorders 显示文摘 | MEMON H U HANDA V L | 2013 | Women''s Health (London England)2013，9，3： | 1 |
| 18 | Pelvic floor disorders 5 - 10 years after vaginal or cesarean childbirth 显示文摘 | HANDA V L BLOMQUIST J L KNOEPP L R | 2011 | Obstetrics and Gynecology2011，118，4： | 1 |
| 19 | Analysis of stresses in turbine rotor using finite element method (FEM) -a past review显示文摘 | NAGPURE H G HANDA C C VANALKAR A V | 2012 | International journal of engineering science and technology2012，4，3： | 1 |
| 20 | Pre-concentration, separation and trace determination of lanthanum (Ⅲ), cerium (Ⅲ), thorium (Ⅳ) and uranium (Ⅳ) on polymer supported o-vanillinsemicarbazone显示文摘 | Jain V Handa A Sait S | 2001 | Analytica Chimica Acta2001，429，2： | 1 |
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