|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is today considered the most common form of chronic liver disease, affecting a high proportion of the population worldwide. NAFLD encompasses a large spectrum of liver damage, ranging from simple steatosis to steatohepatitis, advanced fibrosis and cirrhosis. Obesity, hyperglycemia, type 2 diabetes and hypertriglyceridemia are the most important risk factors. The pathogenesis of NAFLD and its progression to fibrosis and chronic liver disease is still unknown. Accumulating evidence indicates that mitochondrial dysfunction plays a key role in the physiopathology of NAFLD, although the mechanisms underlying this dysfunction are still unclear. Oxidative stress is considered an important factor in producing lethal hepatocyte injury associated with NAFLD. Mitochondrial respiratory chain is the main subcellular source of reactive oxygen species(ROS), which may damage mitochondrial proteins, lipids and mitochondrial DNA. Cardiolipin, a phospholipid located at the level of the inner mitochondrial membrane, plays an important role in several reactions and processes involved in mitochondrial bioenergetics as well as in mitochondrial dependent steps of apoptosis. This phospholipid is particularly susceptible to ROS attack. Cardiolipin peroxidation has been associated with mitochondrial dysfunction in multiple tissues in several physiopathological conditions, including NAFLD. In this review, we focus on the potential roles played by oxidative stress and cardiolipin alterations in mitochondrial dysfunction associated with NAFLD. | Giuseppe Paradies Valeria Paradies Francesca M Ruggiero Giuseppe Petrosillo | 2014 | World Journal of Gastroenterology2014，20，39： | 50 |
| 2 | Expression of connective tissue growth factor in experimental rat and human liver fibrosis 显示文摘 | Paradis V Dargere D Vidaud M | 1999 | Hepathology1999，30，： | 2 |
| 3 | Rating chronic medical illness burden in geropsyehiatric practice and research: application of the Cumulative Illness Rating Scale显示文摘 | Miller M D Paradis C F Houck P R | 1992 | Psychiatry Res1992，41，3： | 1 |
| 4 | Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo显示文摘 | Goodell M A Brose K Paradis G | 1996 | J Exp Med1996，183，4： | 1 |
| 5 | E-cadherin mediates adhesion and suppresses cell motility via distinct mechanisms显示文摘 | Chen H Paradies NE Fedor-Chaiken M | 1997 | J Cell Sci1997，110，3： | 1 |
| 6 | Lipid peroxidation and aGerations to oxidative metabolism in mitochondria isolated from rat heart subi jected to isehemia and reperfusion显示文摘 | ParadieS G Pettosillo G Pistolese M | 1999 | Free Radic Biol Med1999，27，12： | 1 |
| 7 | Decrease in mitochondrial complex Ⅰ activity in ischemic/reperfused rat heart: involvement of reactive oxygen species and cardiolipin显示文摘 | Paradies G Petrosillo G Pistolese M | 2004 | Circ Res2004，94，1： | 1 |
| 8 | Isolation and characterization of APLP'2 encoding a homologue of the Alzheimer' s asso- ciated amyloid beta protein precursor显示文摘 | WASCO W GURUBHAGAVATULA S PARADIS M D | 1993 | Nat Genet1993，5，： | 1 |
| 9 | Isolation and functionalproperties of murine hematopoietic stem cells that are replicating in vivo显示文摘 | Goodell M A Brose K Paradis G | 1996 | J Exp Med1996，183，4： | 1 |
| 10 | Shape control of adaptive composite reflectors显示文摘 | Paradies R Hertwig M | 1999 | Composites Part B:Engineering1999，30，1： | 1 |
| 11 | Expression of connective tissue growth factor in experimental rat and human liver fibrosis显示文摘 | Paradis V Dargere D Vidaud M | 1999 | Hepatology1999，30，： | 1 |
| 12 | Predictors of outcomein infant and toddlers functional or behavioral disorders aftera brief parent-infant psychotherapy 显示文摘 | Herve MJ Paradis M Rattaz C | 2009 | Eur Child AcloLescPsychiatry2009，18，12： | 1 |
| 13 | Expression of connective tissue growth factor in experimental rat and human liver fibrosis显示文摘 | Paradis V Dargere D Vidaud M | 1999 | Hepatology1999，30，4： | 1 |
| 14 | Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo显示文摘 | Goodell M A Brose K Paradis G | 1996 | J Exp Med1996，183，4： | 1 |
| 15 | Isolation and func- tional properties of mufine hematopoietic stem cells that are replica- ring in vivo 显示文摘 | GOODELL M A BROSE K PARADIS G | 1996 | Journal of Experimental Medicine1996，183，4： | 1 |
| 16 | In situ detection of peroxidation byproducts in chronic liver disease 显示文摘 | Paradis V Kollinger M Fabre M | 1997 | Hepatology1997，26，1： | 1 |
| 17 | C-reactive protein and fea- tures of the metabolic syndrome in a population-based sample of chil- dren and adolescents显示文摘 | Lambert M Delvin EE Paradis G | 2004 | Clin Chem2004，50，10： | 1 |
| 18 | Spinal epidural hematoma complicating thrombolytic therapy with tissue plasminogen activator-a case report显示文摘 | Clark M A Paradis N A | 2002 | Emerg Med2002，23，3： | 1 |
| 19 | Modulation of A beta adhesiveness and secretase site cleavage by zinc显示文摘 | Bush A I Pettingell W H Paradis M D Jr | 1994 | JB C1994，269，12： | 1 |
| 20 | Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo 显示文摘 | Goodell M A Brose K Paradis G Conner A S Mulligan R C | 1996 | J Exp Med1996，183，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员