|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mitochondrial DNA from hepatocytes as a ligand for TLR9: Drivers of nonalcoholic steatohepatitis?显示文摘Nonalcoholic fatty liver disease(NAFLD) is the most common liver disease worldwide, affecting approximately one third of the Western world. It consists of a wide spectrum of liver disorders, ranging from fatty liver to nonalcoholic steatohepatitis(NASH), which consists of steatosis, ballooning injury and inflammation. Despite an alarming growth in the statistics surrounding NAFLD, there are as yet no effective therapies for its treatment. Innate immune signaling has been thought to play a significant role in initiating and augmenting hepatic inflammation, contributing to the transition from nonalcoholic fatty liver to NASH. An immune response is triggered by countless signals called damage-associated molecular patterns(DAMPs) elicited by lipid-laden and damaged hepatocytes, which are recognized by pattern recognition receptors(PRRs) on hepatic immune cells to initiate inflammatory signaling. In this editorial, in addition to summarizing innate immune signaling in NAFLD and discussing potential therapies that target innate immune pathways, we have described a recent study that demonstrated that mitochondrial DNA serves as a DAMP activating a hepatic PRR, TLR9, in mice and in the plasma of NASH patients. In addition to identifying a new ligand for TLR9 during NASH progression, the study shows that blocking TLR9 reverses NASH, paving the way for the development of future NASH therapy. | Priya Handa Akhila Vemulakonda Kris V Kowdley Misael Uribe Nahum Méndez-Sánchez | 2016 | World Journal of Gastroenterology2016，22，31： | 3 |
| 2 | Proteins associate with adaptation of cultured tobacco cells to NaCl显示文摘 | Sing N K Handa A K Hasegawa P M | 1985 | Plant Physiol1985，79，： | 2 |
| 3 | A human apoB100 transgenic mouse expresses human apoB100 in the RPE and develops features of early AMD 显示文摘 | Fujihara M Bartels E Nielsen LB Handa JT | 2009 | Exp Eye Res2009，88，6： | 1 |
| 4 | The effect of timing of dot removal on chronic vasospasm in a primate model显示文摘 | Handa Y Weir BKA Nosko M | 1987 | J Neurosurg1987，67，： | 1 |
| 5 | Propofol concentration re- quirement for laryngeal mask airway insertion was highest with the ProSeal, next highest with the Fastrach, and lowest with the Clas- sic type, with target -controlled infusion 显示文摘 | HANDA TSUTSUI F KODAKA M | 2005 | J Clin Anesth2005，17，5： | 1 |
| 6 | Proteomics of the rice cell:Systematic identification of the protein populations in subcellular compartments 显示文摘 | Tanaka N Fujita M Handa H | 2004 | Molecular Genetics andGnomics2004，271，： | 1 |
| 7 | ProteirLs associated with adaptation of cultured tobacco cells to NaCI显示文摘 | SINGH N K HANDA A K HASIA P M | 1985 | Plant Physiology1985，79，1： | 1 |
| 8 | (2006) Single scrotal incision orchidopexy for palpable undescended testis 显示文摘 | Handa R Kale R Harjai M | 2006 | Asian J Surg2006，29，1： | 1 |
| 9 | The correlation between immulogical reaction in the arterial wall and the time coures of the development of cerebral vasospasm in a primate mode显示文摘 | Handa Y Kabuto M Kobayashi H | 1991 | Neurosurgery1991，28，4： | 1 |
| 10 | Evolution of patinas on copper exposed in a suburban area显示文摘 | Watanabe M Toyoda E Handa T | 2007 | Corrosion Science2007，49，： | 1 |
| 11 | Physical and molecular properties of egg -white lipid films 显示文摘 | Handa A Gennadlos A Hanna M A | 1999 | Food Chemistry and Toxicology1999，64，5： | 1 |
| 12 | Effect of an antioxidant, ebselen, on development of chronic cerebral vasospasm after subarachnoid hemorrhage in primates显示文摘 | Handa Y Kaneko M Takeuchi H | 2000 | Surg Neurol2000，53，： | 1 |
| 13 | Adventitial delivery of platelet-derivedendothelial cell growth factor gene prevented intimal hyperplasia of veingraft显示文摘 | Handa M Li W Morioka K | 2008 | J Vase Surg2008，48，6： | 1 |
| 14 | Progenitor cells from dental follicle are able to form cementum matrix in vivo显示文摘 | Handa K Saito M Tsunoda A | 2002 | Connect Tissue Res2002，43，23： | 1 |
| 15 | Biomechanical study of the constitutive laws of vascular wall显示文摘 | Hayashi K Sato M Handa H | 1979 | Exp Mechanics1979，14，： | 1 |
| 16 | Esophageal motility and psychiatric factors in functional dyspepsia patients with or without pain显示文摘 | Mine K Yamamoto H | 1999 | Dig Dis Sci1999，44，10： | 1 |
| 17 | Proteomics of the Rice Cell: Systematic Edentification of the Protein Populations in Subcellular Compartments 显示文摘 | TANKA N FUJITA M HANDA H | 2004 | Mol Genet Genomics2004，271，： | 1 |
| 18 | Evaluation of pressure changes in feeding arteries during embolization of inttracerebral arteriovenous malformations显示文摘 | Handa T Negoro M Miyachi S | 1993 | J Neurosurg1993，79，3： | 1 |
| 19 | Ultrasonic evaluation of early carotid atherosclerosis 显示文摘 | Handa N Matsumoto M Maeda H | 1990 | Stroke1990，21，11： | 1 |
| 20 | Effect of compressed CO2 on crystallization and melting behavior of isotactic polyproplene显示文摘 | Varma-Nair M Handa P Y Mehta A K | 2003 | ThermochimicaActa2003，396，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员