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168篇 您的检索式:作者名="Hand E"
    题名 作者 年代 出处 被引量
1Defining the nature of human pluripotent stem cell progeny显示文摘当人的 pluripotent 干细胞(hPSCs ) 能区分产生各种各样的房间类型的一件礼服,是清楚的时,在 vitro,开发怎么仔细反射那,是未知的哪个发生在 vivo。决定人的胚胎的干细胞(hESCs ) 和导致人的 pluripotent 干细胞(hiPSCs ) 是否做相等的子孙,并且是否也使房间成为那类似于导出织物的房间,我们执行了净化的 PSC 衍生物和他们的导出织物的对应物介绍的全面 transcriptome。表示介绍证明 hESCs 和 hiPSCs 在 hiPSC 子孙用外长的 reprogramming 因素为重新表示的神经、肝、间充质的系,和缺席做将近相同的子孙。不管多么与一个导出织物的对应物相比, hESCs 和 hiPSCs 的子孙维持了通常与早哺乳动物的开发联系的基因的一个子集的表示,不管产生的房间的类型。当 pluripotent 基因(OCT4, SOX2, REX1,和 NANOG ) 看起来在从 hPSCs 的区别之上立即是 silenced 时,对早胚胎(LIN28A, LIN28B, DPPA4,和其它) 通常独特的基因不是充分在 hPSC 衍生物的 silenced。从在早人的胎儿的织物(开发的 3-16 星期) 的表达式模式的这些数据和证据建议 hPSCs 的区分的子孙很早人的开发是反射的(< 6 个星期) 。这些调查结果为 hPSCs 能在早人的开发的 vitro 模型作为有用服务的想法提供支持,而且为疾病建模和 hPSC 衍生物的临床的申请提出重要问题。Michaela Patterson David N Chan IrisHa Dana Case Yongyan Cui Ben Van Hande Hanna KA Mikkola William E Lowry 2012Cell Research2012,22,1:2
2Determining layer contributions to rutting by surface profile analysis显示文摘HADDOCK J E HAND A J T FANG Hong-bing 2005Journal of Transportation Engineering2005,131,2:1
3Quantification of mRNA using real-time RT-PCR 显示文摘Nolan T Hands R E Bustin S A 2006Nat Protoc2006,1,3:1
42006, Quantification of mRNA using Real-time RT-PCR显示文摘Nolan T Hands R E Bustin S A 2006Nature Protocols2006,1,3:1
52007 focused update of the ACC/AHA 2004 guidelines for the management of patients with ST- elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines显示文摘Antman E M Hand M Armstrong P W 2008J Am Call Cardiol2008,51,2:1
6Allopurind kinetics显示文摘Hande K Reed E Chabner B 0,,:1
7Inorganic trimetaphosphatase as a histochemical marker for lysosomes in light and electron microscopy 显示文摘Doty S B Smith C E Hand AR 1977J Histochem Cytochem1977,25,12:1
8Head in the clouds显示文摘Hand E 2007Nature2007,,449:1
9K-nearest neighbor classifier for assessing consumer credit risk显示文摘Henley W E Hand D J 1996Statistician1996,44,:1
10Philae probe makes bumpy touchdown on a comet显示文摘Hand E 2014Science2014,346,6212:1
11The Leu262Val polymorphism of presenilin associated rhomboid like protein(PARL)is associated with earlier onset of type 2 diabetes and increased urinary microalbumin creatinine ratio in an Irish case-control population显示文摘Hatunic M Stapleton M Hand E 0,,03:1
12Living with wa-ter stress: evolution of osmolyte systems显示文摘YANCEY P H CLARK M E HAND S C 1982Science1982,217,:1
13Wrist fractures显示文摘Hand D P Jones M D Trumble T E 2002Orthop Clin North Am2002,33,1:1
142007 fo- cused update of the ACC/AHA 2004 guidelines for the man- agement of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association task force on practice guidelines: devel- oped in collaboration with the Canadian Cardiovascular Soci- ety endorsed by the American Academy of Family Physi- cians: 2007 writing group to review new evidence and up- date the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction, writing on behalf of the 2004 writing committee 显示文摘Antman E M Hand M Armstrong P W 2008Circulation2008,117,2:1
15Aerosol size distributions and visibility estimates during the big bend regional aerosol and visibility observational (BRAVO) study 显示文摘Hand J L Kreidenweis S M Sherman D E 2002Atoms Environ2002,36,:1
16On the Characterization of Flexible Pavement Rutting Using Creep Model-based Finite Element Analysis 显示文摘Fang Hongbing J E Haddock White D T Hand A J 2004Finite Elements in Analysis and Design2004,41,:1
17Quantification of mRNA using real-time RT-PCR显示文摘Nolan T Hands R E Bustin S A 2006Nature Protocols2006,,1:1
18Toward understanding evidence uptake, semirecubency for pneumonia prevention显示文摘COOK D J MEADE M O HAND L E 2002Crit Care Med2002,30,7:1
19Can reject inference ever work?显示文摘Hand D J Henley W E 1993IMA Journal of Mathematics Applied in Business and Industry1993,,5:1
20Toward understan- ding evidence uptake: semirecumbency for pneumonia prevention 显示文摘COOK D J MEADE M O HAND L E 2002Crit Care Med2002,30,7:1
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