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| 1 | Evaluation of three-dimensional biofilms on antibacterial bonding agents containing novel quaternary ammonium methacrylates显示文摘Antibacterial adhesives are promising to inhibit biofilms and secondary caries.The objectives of this study were to synthesize and incorporate quaternary ammonium methacrylates into adhesives,and investigate the alkyl chain length effects on three-dimensional biofilms adherent on adhesives for the first time.Six quaternary ammonium methacrylates with chain lengths of 3,6,9,12,16 and 18were synthesized and incorporated into Scotchbond Multi-Purpose.Streptococcus mutans bacteria were cultured on resin to form biofilms.Confocal laser scanning microscopy was used to measure biofilm thickness,live/dead volumes and live-bacteria percentage vs.distance from resin surface.Biofilm thickness was the greatest for Scotchbond control;it decreased with increasing chain length,reaching a minimum at chain length 16.Live-biofilm volume had a similar trend.Dead-biofilm volume increased with increasing chain length.The adhesive with chain length 9 had 37%live bacteria near resin surface,but close to 100%live bacteria in the biofilm top section.For chain length 16,there were nearly 0%live bacteria throughout the three-dimensional biofilm.In conclusion,strong antibacterial activity was achieved by adding quaternary ammonium into adhesive,with biofilm thickness and live-biofilm volume decreasing as chain length was increased from 3 to 16.Antibacterial adhesives typically only inhibited bacteria close to its surface;however,adhesive with chain length 16 had mostly dead bacteria in the entire three-dimensional biofilm.Antibacterial adhesive with chain length 16 is promising to inhibit biofilms at the margins and combat secondary caries. | Han Zhou Michael D Weir Joseph M Antonucci Gary E Schumacher Xue-Dong Zhou Hockin H K Xu | 2014 | International Journal of Oral Science2014，6，2： | 5 |
| 2 | Molecular basis for the herbicide resistance of roundup ready crops显示文摘 | Todd F Han H J Healy-Fried M L Fischer M Schnbrunn E | 2006 | Proceedings of the National Academy of Sciences of the United States of America2006，，13： | 1 |
| 3 | Regeneration of a transgenic woody Legume (Robinia pseudoacacia L,black Locust) andmorphological alterations inducedby Agrobacterium rhiaogenes-mediatedtransformaion显示文摘 | HAN K H KEATHLEY D E DAVIS J M | 1993 | Plant Sci1993，88，2： | 1 |
| 4 | Plastic ELISA-on-a-chip based on sequential cross-flow chromatography 显示文摘 | Cho J H Han S M Paek E H | 2006 | Anal Chem2006，78，3： | 1 |
| 5 | Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer显示文摘 | Wolff E M Byun H M Han H F | 2010 | PLoS Genet2010，6，10： | 1 |
| 6 | Delay-dependent H control of linear discrete-time systems with an interval-like time-varying delay显示文摘 | Yong H E WU M HAN Q L | 2008 | Int J Syst Sci2008，39，4： | 1 |
| 7 | Facile preparation of 3, 4-diarylpyrroles and hydrogen by a platinum(II) terpyridyl complex显示文摘 | Wang D H Peng M L Han Y Chen E Tung C H Wu L Z | 2009 | Inorganic Chem- istry2009，48，99： | 1 |
| 8 | Catalytic pyrolysis of CHF3 over activated carbon and activated carbon supported potassium catalyst显示文摘 | Han W F Kennedy E M Liu H Z | 2010 | Journal of Fluorine Chemistry2010，131，6： | 1 |
| 9 | Electrolytic Coloration of Oxygen-doped Lithium Fluoride Crystals显示文摘 | Guo M L Gu H E Han L | 2006 | Journal of Applied Physics2006，100，1： | 1 |
| 10 | Luteolin inhibits the nuclear factor-KB transcriptional activity in Rat-1 fibroblasts显示文摘 | KIM S H SHIN K J KIM D KIM Y H HAN M S LEE T G KIM E RYU S H SUH P G | 2003 | Biochemical Pharmacology2003，66，6： | 1 |
| 11 | Preparation and opticalproperties of polystyrene nanocapsules containing photo-chromophores显示文摘 | Han M J Lee E H Kim E K | 2002 | Optical Materials2002，，21： | 1 |
| 12 | Enhanced photodecomposition of 4-chlorophenol in aqueous solution by deposition of CdS on TiO2显示文摘 | Kang M G Han H E Kim K J | 1999 | Journal of Photochemistry and Photobiology A:Chemistry1999，125，： | 1 |
| 13 | Total synthesis of a functional designer eukaryotic chromosome 显示文摘 | Annaluru N Muller H Mitchell L A Ramalingam S Stracquadanio G Richardson S M Dymond J S Kuang Z Scheifele L Z Cooper E M Cai Y Z Zeller K Agmon N Han J S Hadjithomas M Tullman J Caravelli K Cirelli K Guo Z Y London V Yeluru A Murugan S Kandavelou K Agier N Fischer G Yang K Martin J A Bilgel M Bohutski P Boulier K M Capaldo B J Chang J Charoen K Choi W J Deng P Dicarlo J E Doong J Dunn J Feinberg J I Fernandez C Floria C E Gladowski D Hadidi P Ishizuka I Jabbari J Lau C Y L Lee P A Li S Lin D Linder M E Ling J Liu J Liu J London M Ma H Mao J Mcdade J E Mcmillan A Moore A M Oh W C Ouyang Y Patel R Paul M Paulsen L C Qiu J Rhee A Rubashkin M G Soh I Y Sotuyo N E Srinivas V Suarez A Wong A Wong R Xie W R Xu Y J Yu A T Koszul R Bader J S Boeke J D Chandrasegaran S | 2014 | Science2014，344，6179： | 1 |
| 14 | Enhanced photodecomposition of 4-chlorophenol in aqueous solution by deposition of CdS on TiOz 显示文摘 | KANG M C HAN H E KIM K J | 1999 | Journal of Photochemistry and Photobiology A: Chemistry1999，125，： | 1 |
| 15 | Enhanced photodecomposition of 4-chlorophenol in aqueous solution by deposition of CdS on TiO2 显示文摘 | Kang M G Han H E Kim K J | 1999 | Journal of Photochemistry and Photobiology A: Chemistry1999，125，： | 1 |
| 16 | Social network a- nalysis of collaborative ventures for overseas construc- tion projects 显示文摘 | Park H Han S H Rojas E M | 2010 | Journal of Construction Engineering and Management2010，137，5： | 1 |
| 17 | Purification and characterization of two novel beta-d-glucuronidases converting glycyrrhizin to 18-glycyrrhetinic acid-3-0-beta-D-glucuronide from Streptococcus LJ-22显示文摘 | Park H Y Kim NY Han M J Bae E A Kim D H | 2005 | Journal of Microbiology and Biotechnology2005，15，4： | 1 |
| 18 | Enhanced photodecomposition of 4-chlorophenol in aqueous solution by deposition of CdS on TiO2 显示文摘 | Kang M G Han H E Kim K J | 1999 | J Photochem Photobiol A:Chem1999，125，123： | 1 |
| 19 | Fully sealed, high-brightness carbon-nanotube field-emission display 显示文摘 | CHOI W B CHUNG D S KANG J H KIM H Y JIN Y W HAN I T LEE Y H JUNG J E LEE N S PARK G S KIM J M | 1999 | Appl Phys Lett1999，75，： | 1 |
| 20 | Cancer spheres from gas- tric cancer patients provide an ideal model system for cancer stem cell research显示文摘 | Han M E Jean T Y Hwang S H | 2011 | Cell Mol Life Sci2011，68，21： | 1 |
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