|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 2 | The elastic compensation method for limit and shakedown analysis:a review显示文摘 | D Mackenzie J T Boyle R Hamilton | 2000 | Journal of Strain Analysis2000，35，3： | 1 |
| 3 | Natural occurrences of ochratoxicosis in poultry显示文摘 | Hamilton P A T B Huff W E Harris J R A Y | 1982 | Poultry Science1982，61，9： | 1 |
| 4 | Simplified lower bound limit analysis of pressurized cylinder/cylinder intersections using generalized yield criteria显示文摘 | R Hamilton D Mackenzie J Shi J T Boyle | 1996 | Int J Pres Ves and Piping1996，67，2： | 1 |
| 5 | Granulo- cyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophagc phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation 显示文摘 | Fleetwood AJ Lawrence T Hamilton JA | 2007 | J Immunol2007，178，： | 1 |
| 6 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 7 | Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis显示文摘 | Creticos P S Schroeder J T Hamilton R G | 2006 | N Engl J Med2006，355，： | 1 |
| 8 | Sound velocity and related properties of marine sediments 显示文摘 | Hamilton E L Bachman T | 1982 | Journal of the A- coustical Society of America1982，72，： | 1 |
| 9 | Metabolism and biliary excretion of the novel anticancer agent 10-hydroxycamptothecin in the isolated perfused rat liver显示文摘 | Platzer P Thalhammer T Reznicek G Hamilton G Zhang R Jager W | 2001 | Int J Oncol2001，19，： | 1 |
| 10 | Feature fatigue: When product capabilities become too much of a good thing 显示文摘 | Thompson D V Hamilton R W Rust R T | 2005 | Journal of Marketing Research2005，42，4： | 1 |
| 11 | Therapeutic regulation of endothelial dysfunction in type 2 diabetes mellitus 显示文摘 | Chew G T Hamilton S J Watts G F | 2007 | Diabet Vase Res2007，4，： | 1 |
| 12 | A novel activation mechanism of avian influenza virus H9N2 by furin显示文摘 | Tse LV Hamilton AM Friling T | 2014 | J Virol2014，88，3： | 1 |
| 13 | TGF-beta inhibits LPS-induced chemokine mRNA stabilization显示文摘 | Dai Y Datta S Novotny M Hamilton T | 2003 | Blood2003，102，4： | 1 |
| 14 | Exercise,antioxidants,and HSP72:protection against myocardial ischemia/reperfusion显示文摘 | Hamilton K L Staib J L Phillips T | 2003 | Free Radic Biol Med2003，34，7： | 1 |
| 15 | Radiation-induced changes in cellularity and proliferation in human oral mucosa显示文摘 | Dorr W Hamilton CS Boyd T | 2002 | Int J Radiat Oncol Biol Phys2002，52，4： | 1 |
| 16 | Lead tetrakis(imidazotyt)borate solids: anion exchange, sol- vent intercalation, and self assembly of an organic anion 显示文摘 | HAMILTON B H KELLY K A WAGLER T A | 2004 | Inorg Chem2004，43，1： | 1 |
| 17 | Lymphocytic gastritis: association with etiology and topotogy显示文摘 | WU T T HAMILTON S R | 1999 | Am J Surg Pathol1999，23，2： | 1 |
| 18 | Metal injec- tion moulding of CP-Ti components for biomedical applica- tions显示文摘 | Sidambe A T Figueroa I A Hamilton H | 2012 | J Mater Process Teehnol2012，212，： | 1 |
| 19 | Short-term exercise training can improve myocardial tolerance to I/R without elevation in heat shock proteins 显示文摘 | Hamilton KL Powers SK Sugiura T | 2001 | Am J Physiol Heart Circ Physiol2001，281，3： | 1 |
| 20 | The roles of the Hadley circulation and downward control in tropical upwelling显示文摘 | Zhou T Geller M A Hamilton K | 2006 | Journal of the Atmospheric Sciences2006，63，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员