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| 1 | Current issues and future perspectives of gastric cancer screening显示文摘Gastric cancer remains the second leading cause of cancer death worldwide. About half of the incidence of gastric cancer is observed in East Asian countries,which show a higher mortality than other countries. The effectiveness of 3 new gastric cancer screening techniques,namely,upper gastrointestinal endoscopy,serological testing,and 'screen and treat' method were extensively reviewed. Moreover,the phases of development for cancer screening were analyzed on the basis of the biomarker development road map. Several observational studies have reported the effectiveness of endoscopic screening in reducing mortality from gastric cancer. On the other hand,serologic testing has mainly been used for targeting the high-risk group for gastric cancer. To date,the effectiveness of new techniques for gastric cancer screening has remained limited. However,endoscopic screening is presently in the last trial phase of development before their introduction to population-based screening.To effectively introduce new techniques for gastric cancer screening in a community,incidence and mortality reduction from gastric cancer must be initially and thoroughly evaluated by conducting reliable studies.In addition to effectiveness evaluation,the balance of benefits and harms must be carefully assessed before introducing these new techniques for population-based screening. | Chisato Hamashima | 2014 | World Journal of Gastroenterology2014，20，38： | 46 |
| 2 | Impact of endoscopic screening on mortality reduction from gastric cancer显示文摘AIM:To investigate mortality reduction from gastric cancer based on the results of endoscopic screening.METHODS:The study population consisted of participants of gastric cancer screening by endoscopy,regular radiography,and photofluorography at Niigata city in 2005.The observed numbers of cumulative deaths from gastric cancers and other cancers were accumulated by linkage with the Niigata Prefectural Cancer Registry.The standardized mortality ratio(SMR)of gastric cancer and other cancer deaths in each screening group was calculated by applying the mortality rate of the reference population.RESULTS:Based on the results calculated from the mortality rate of the population of Niigata city,the SMRs of gastric cancer death were 0.43(95%CI:0.30-0.57)for the endoscopic screening group,0.68(95%CI:0.55-0.79)for the regular radiographic screening group,and 0.85(95%CI:0.71-0.94)for the photofluorography screening group.The mortality reduction from gastric cancer was higher in the endoscopic screening group than in the regular radiographic screening group despite the nearly equal mortality rates of all cancers except gastric cancer.CONCLUSION:The 57%mortality reduction from gastric cancer might indicate the effectiveness of endoscopic screening for gastric cancer.Further studies and prudent interpretation of results are needed. | Chisato Hamashima Kazuei Ogoshi Rintarou Narisawa Tomoki Kishi Toshiyuki Kato Kazutaka Fujita Masatoshi Sano Satoshi Tsukioka | 2015 | World Journal of Gastroenterology2015，21，8： | 16 |
| 3 | Benefits and harms of endoscopic screening for gastric cancer显示文摘Gastric cancer has remained a serious burden worldwide, particularly in East Asian countries. However, nationwide prevention and screening programs for gastric cancer have not yet been established in most countries except in South Korea and Japan. Although evidence regarding the effectiveness of endoscopic screening for gastric cancer has been increasingly accumulated, such evidence remains weak because it is based on results from studies other than randomized controlled trials. Specifically, evidence was mostly based on the results of cohort and case-control studies mainly conducted in South Korea and Japan. However, the consistent positive results from these studies suggest promising evidence of mortality reduction from gastric cancer by endoscopic screening. The major harms of endoscopic screening include infection, adverse effects, false-positive results, and overdiagnosis. Despite the possible harms of endoscopic screening, information regarding these harms remains insufficient. To provide appropriate cancer screening, a balance of benefits and harms should always be considered when cancer screening is introduced as a public policy. Quality assurance is very important for the implementation of cancer screening to provide high-quality and safe screening and minimize harms. Endoscopic screening for gastric cancer has shown promising results, and thus deserves further evaluation to reliably establish its effectiveness and optimal use. | Chisato Hamashima | 2016 | World Journal of Gastroenterology2016，22，28： | 10 |
| 4 | Overdiagnosis of gastric cancer by endoscopic screening显示文摘Gastric cancer screening using endoscopy has recently spread in Eastern Asian countries showing increasing evidence of its effectiveness. However, despite the benefits of endoscopic screening for gastric cancer, its major harms include infection, complications, falsenegative results, false-positive results, and overdiagnosis. The most serious harm of endoscopic screening is overdiagnosis and this can occur in any cancer screening programs. Overdiagnosis is defined as the detection of cancers that would never have been found if there is no cancer screening. Overdiagnosis has been estimated from randomized controlled trials, observational studies, and modeling. It can be calculated on the basis of a comparison of the incidence of cancer between screened and unscreened individuals after the follow-up. Although the estimation method for overdiagnosis has not yet been standardized, estimation of overdiagnosis is needed in endoscopic screening for gastric cancer. To minimize overdiagnosis, the target age group and screening interval should be appropriately defined. Moreover, the balance of benefits and harms must be carefully considered to effectively introduce endoscopic screening in communities. Further research regarding overdiagnosis is warranted when evaluating the effectiveness of endoscopic screening. | Chisato Hamashima | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，2： | 4 |
| 5 | The Japanese guideline for cervical cancer screening显示文摘 | Hamashima C Aoki D Miyagi E | 2010 | Jpn J Clin Oncol2010，40，6： | 1 |
| 6 | Pathology of the heart in Kawasaki disease 显示文摘 | Fujiwara H Hamashima Y | 1978 | Pediatrics1978，61，1： | 1 |
| 7 | Characterization of the antiseptic - resistance gene qacE delta 1 isolated from clinical and environmental isolates of Vibrio parahaemolyticus and Vibfio cholerae non- O1 显示文摘 | Kazama H Hamashima H Sasatsu M | 1999 | FEMS Microbiol Lett1999，174，2： | 1 |
| 8 | Cost-effectiveness analysis of prostate cancer screening显示文摘 | Chisato Hamashima Katsumi Yoshida | 2000 | Environmental Health and Preventive Medicine2000，，3： | 1 |
| 9 | Inhibition of hsrphal extension factor formation by validamycin in Rhizoctonia solani 显示文摘 | SHIBATA M MOR1 K HAMASHIMA M | 1982 | The Journal of Antibiotics1982，35，10： | 1 |
| 10 | Endoscopic variceal ligation combined with sclerotherapy vs endoscopic sclerotherapy:a comparative study显示文摘 | Yoo JK Sakaguchi T Hamashima H etal | 1995 | Gastroenterology1995，108，： | 1 |
| 11 | Pathology of the heart in Kawasaki disease显示文摘 | Fujiwara H Hamashima Y | 1978 | Pediatrics1978，61，： | 1 |
| 12 | Synthesis and biological properties of 713 - - 3 - cemphem - 4 - carboxylic acid (7432 - S), a new oral cephem antibiotic显示文摘 | Hamashima Y Kubota T Minami K | 1987 | J Antibiot1987，40，10： | 1 |
| 13 | Distribution of the antiseptic -resistance gene qacE and qacE delta 1 in gram- positive bacteria 显示文摘 | Kazama H Hamashima H Sasatsu M | 1998 | FEMS Microbiol Lett1998，159，2： | 1 |
| 14 | Portal hypertension in children and young adults: sonographic and color Doppler findings显示文摘 | A. Uno H. Ishida K. Konno Y. Ohnami H. Naganuma M. Niizawa Y. Hamashima O. Masamune | 1997 | Abdominal Imaging1997，，1： | 1 |
| 15 | The Japaneseguidelines for gastric cancer screening显示文摘 | Hamashima C Shibuya D Yamazaki H | | 0，，04： | 1 |
| 16 | Distribution of the antiseptic-resistance gene qacE delta 1 in Gram-positive bacteria显示文摘 | Kazama H Sasatsu M Hamashima H | 1998 | FEMS Microbiol Lett1998，165，： | 1 |
| 17 | Pancreatic uncinate carcinoma: sonographic findings显示文摘 | M. Sato H. Ishida K. Konno Y. Hamashima H. Naganuma T. Komatsuda M. Funaoka J. Ishida S. Watanabe | 2001 | Abdominal Imaging2001，，1： | 1 |
| 18 | Plasma levels of secretory IgA in patients with gastric cancer显示文摘 | Gakuji Ohshio Hiroyuki Kudo Hideyuki Yoshioka Atsushi Nonaka Tadao Manabe Takayoshi Tobe Yoshihiro Hamashima | 1987 | Journal of Cancer Research and Clinical Oncology1987，，6： | 1 |
| 19 | Sensitivity of endoscopic screening for gastric cancer by the incidence method显示文摘 | Chisato Hamashima Mikizo Okamoto Michiko Shabana Yoneatsu Osaki Takuji Kishimoto | 2013 | Int J Cancer2013，，3： | 1 |
| 20 | Distribution of antiseptic-resistance gene qacE in Gram negative bacteria显示文摘 | Kazama H Hamashima H Sasatsu M | 2006 | FEMS Microbiol Lett2006，224，2： | 1 |
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