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| 1 | Improved scoring system for the electrocardiographic diagnosis of left ventricular hypertrophy显示文摘BACKGROUND Left ventricular hypertrophy(LVH) is a common manifestation of cardiovascular disease and a risk factor for cardiovascular morbidity and mortality, but available methods for its electrocardiographic(ECG) diagnosis have limited accuracy.AIM To investigate findings associated with LVH on ECG and developed an improved system for the diagnosis of LVH.METHODS A cohort study comparing ECG data acquired within 30 days of transthoracic echocardiography(TTE) was performed. Multivariate regression analysis identified ECG findings associated with increased LV mass and mass index. A scoring system was derived and performance compared to established criteria for LVH.RESULTS Data from 5486 outpatients with TTEs and corresponding ECGs were included in the derivation cohort, 333(6.1%) of whom had LVH by TTE. In the primary regression analysis, findings associated with LVH were amplitudes of Q in V3, R in V6, S in V3, T in V6, P' in V1, P in V6, as well as R and T-axis discordance, R peak time in V6, QRS duration, weight, height, sex, and age. From this we derived a score consisting of 5 criteria, and validated it in an independent cohort of 910 patients. With a threshold of 1.5 points, sensitivity and specificity were67.9% and 81.4%, and 62.5% and 83.2% in the derivation and validation cohorts,respectively. With a threshold of 2 points, sensitivity and specificity were 42.3% and 93.0%, and 37.5% and 93.4% in these cohorts.CONCLUSIONS This score had superior sensitivity for detection of LVH by ECG while making a modest sacrifice in specificity compared to conventional criteria. | Eric D Braunstein Lori B Croft Jonathan L Halperin Steve L Liao | 2019 | World Journal of Cardiology2019，11，3： | 2 |
| 2 | Parity effects in small superconducting particles 显示文摘 | Berger S D Halperin B I | 1998 | Phys Rev B1998，58，： | 1 |
| 3 | Safety andimmunogenicity of three different formulations of a liquidhexavalent diphtheria-tetanus-acellular pertussis-inactivatedpoliovirus-Haemophilus influenzae b conjugate-hepatitis B vac-cine at 2,4,6 and 12-14 months of age显示文摘 | Diaz-Mitoma F Halperin SC Tapiero B | 2011 | 29(6):1324-13312011，29，6： | 1 |
| 4 | Safety and immunogenicity of a trivalent, inactivated, mammalian cell culture-derived influenza vaccine in healthy adults, seniors, and children显示文摘 | Halperin S Smith B Mabrouk T | 2002 | Vaccine2002，20，78： | 1 |
| 5 | A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co - administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant 显示文摘 | Van Nest G Smith B | 2003 | Vaccine2003，21，： | 1 |
| 6 | Safety and immunogenicity of a trivalent,inactivated,mammalian cell culture-derived influenza vaccine in healthy adults,seniors,and children显示文摘 | Halperin S A Smith B Mabrouk T | 2002 | Vaccine2002，20，： | 1 |
| 7 | Unstable angina in a patient with anomalous origin of the left main coronary artery from the right sinus of Valsalva 显示文摘 | Trost B Halperin JL | 2010 | Rev Cardiovasc Med2010，11，2： | 1 |
| 8 | Largevolume liposuction: akeview of 631 consecutive cases over 12 years 显示文摘 | Commons GW Halperin B Chang CC | 2001 | Plast Reconstr Surg2001，108，5： | 1 |
| 9 | Safety and immu- nogenicity of a trivalent, inactivated, mammalian cell culture de- rived influenza vaccine in healthy adults, seniors, and children 显示文摘 | HALPERIN S A SMITH B MABROUK T | 2002 | Vaccine2002，20，78： | 1 |
| 10 | Large-volume liposuction: a review of 631 consecutive cases over 12 years 显示文摘 | Commons GW Halperin B Chang CC | 2001 | Plast Reconstr Surg2001，108，： | 1 |
| 11 | Evaluation of the portable chest roentgenogram for quantitating extravascular lung water in critically ill adults显示文摘 | Halperin B D Feeley T W Mihm F G | 1985 | Chest1985，88，： | 1 |
| 12 | Nonlinear phonon in fused silica below 1 K显示文摘 | Brage G Graebner J E Halperin B I | 1973 | Appl Opt1973，31，6： | 1 |
| 13 | Prevention of stroke in patients with atrial fibrillation: Department of Cardiology, University Hospital, Lund, Sweden显示文摘 | OLSSON S B HALPERIN J L | 2005 | Sevain Vase Med2005，5，： | 1 |
| 14 | A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-ad- ministered with an immunostimulatory phasphorothioate oligodeoxynu- cleotide adjuvant显示文摘 | Halperin SA Van Nest G Smith B | 2003 | Vaccine2003，21，1920： | 1 |
| 15 | Comparison of safety and immunogenicity of two doses of investigational hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligodeoxyribonucleotide and three doses of a licensed hepatitis B vaccine in healthy adults 18-55 years of age 显示文摘 | Halperin SA Ward B Cooper C | 2012 | Vaccine2012，30，15： | 1 |
| 16 | Safety and immuno-genicity of a trivalent,inactivated,mammalian cell culture-de-rived influenza vaccine in healthy adults,seniors,and children显示文摘 | Halperin S A Smith B Mabrouk T | 2002 | Vaccine2002，20，： | 1 |
| 17 | A little more, a lot better: Improving path quality by a path-merging algorithm 显示文摘 | RAVEH B ENOSH A HALPERIN D | 2011 | IEEE Transactions on Robotics2011，27，2： | 1 |
| 18 | Theory of two-dimen- sional melting 显示文摘 | HALPERIN B I NELSON D R | 1978 | Physical Review Letter1978，41，2： | 1 |
| 19 | Phase 1 first in-human studies of the reactogenicity and immunogenicity of a recombinant meningococcal NspA vaccine in healthy adults 显示文摘 | Halperin SA Langley JM Smith B | 2007 | Vaccine2007，25，3： | 1 |
| 20 | Phase 1 first-in- human studies of the reactogenicity and immunogenicity of a recombinant meningococcal NspA vaccine in healthy adults显示文摘 | Halperin SA Langley JM Smith B | 2007 | Vaccine2007，25，17： | 1 |
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