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| 1 | Effects of novel vaccines on weight loss in diet-induced-obese(DIO) mice显示文摘The purpose of the study was to test the therapeutic effects of novel vaccines for reducing weight gain and increasing weight loss in diet induced obesity (DIO) model. Male C57BL/6 J mice, fed a 60% Kcal fat diet for 8 weeks prior to the start of the study, were vaccinated via the intraperitoneal route with two formulations (JH17 & JH18) of chimeric-somatostatin vaccines at 1 and 22 days of the study. Control mice were injected with PBS. All mice continued to be feed the 60% Kcal fat diet for the 6 week study. Body weights were measured two times a week and food intake was measured weekly. At week 6, mice were euthanized and a terminal bleed was made and antibody levels to somatostatin and levels of insulin-like growth factor 1 (IGF-1) were determined. Vaccination with both vaccine formulations induced a statistically significant body weight change over the study period, as compared with PBS controls. Percentage of baseline body weight was also significantly affected by vaccination during the study period. Vaccinates finished the study at 104% and 107% of baseline weight, JH17 & JH18 respectively, while untreated controls reached 115% of baseline weight. Food intake per mouse was similar in all mouse groups during the entire study. Control mice did not demonstrate any antibody titers to somatostatin, while all vaccinated mice had measurable antibody responses (> 1:500,000 titer). IGF-1 levels were not statistically significant among the groups, but were elevated in the JH18 vaccinates (mean 440.4 ng/mL) when compared with PBS controls (mean 365.6 ng/mL). Vaccination with either JH17 or JH18 chimeric-somatostatin vaccines produced a statistically significant weight loss as compared with PBS controls (P < 0.0001), even though the DIO mice with continually fed a 60% Kcal fat diet. The weight loss/lower weight gain observations were even more significant, as all mice consumed similar amounts of food for the entire study. The presence of high levels of anti-somatostatin antibodies at 6 weeks was correlative with the weight observations and confirmed the success of vaccination. | Keith N Haffer | 2012 | Journal of Animal Science and Biotechnology2012，3，3： | 3 |
| 2 | Dyslipidemia man- agement in adults with diabetes 显示文摘 | Haffer SM American Diabetes Association | 2004 | Diabetes Care2004，27，1： | 1 |
| 3 | Insulin-resistant prediabetie subjects have more atherogenic risk factors than insulin-sensitive prediabetie subjects: implications for preventing coronary heat disease during the prediabetie state显示文摘 | HAFFER S M | 2000 | Circulation2000，101，： | 1 |
| 4 | Prospective analysis of the insulin resistance syndrome(syndrome x)显示文摘 | Haffer SM Valdez RA Hazuda HP | 1992 | Diabetes1992，41，： | 1 |
| 5 | Molecular Cytogenetic and Rapid Aneuploidy Detection Methods in Prenatal Diagnasis显示文摘 | Haffer LG Bui TH | 2007 | American Journal of Medical Genetics Part C2007，145，1： | 1 |
| 6 | The insulin resistance syndrome revisited显示文摘 | Haffer SM | | 0，，03： | 1 |
| 7 | Diabetes, hyperlipidemia, and coronary artery disease 显示文摘 | Steven M Haffer | 1999 | The American Journal of Cardiology1999，83，9： | 1 |
| 8 | Inhibition of HIV replication by pokeweed antiviral protein targeted to CD4+ cells by monoclonal antibodies显示文摘 | Zarting JM Moran PA Haffer O | 1990 | Nature1990，347，： | 1 |
| 9 | Cyclic adenosine monophosphate: possible mediator for norepinephrine effects on cerebellar purkine cells显示文摘 | Siggins GH Haffer JH Bloom FE | 1969 | Science1969，165，： | 1 |
| 10 | Sustainable leather manufacturing a topic with growing importance显示文摘 | Haffer S Taeger T | 2004 | J Am Leather Chem Assoc2004，99，10： | 1 |
| 11 | Total immunoreactive proinsulin, immunoreactive proinsulin and specific insulin in relation to conversion to type 2 diabetes: the Mexico City Diabetes Study显示文摘 | Haffer SM Gonzalez C Mykkannen L | 1997 | Diabetologia1997，40，： | 1 |
| 12 | NCEP- defined metabolic syndrom diabetes, and prevalence of coronary of coronary heart disease among NHANES Ⅲ participants age 50 years and older显示文摘 | Alexander CM Landsman PB Teutsch SM Haffer SM | 2003 | Diabetes2003，52，5： | 1 |
| 13 | Molecular cytogenetic and rapid aneuploidy detection methods in prenatal diagnosis显示文摘 | Haffer LG Bui TH | 2007 | Am J Mod Genet Part C2007，145，1： | 1 |
| 14 | Prospective analysis of the insulin resistance sydrome显示文摘 | Haffer SM valdez RA Hazude HP | 1992 | Diabetes1992，41，： | 1 |
| 15 | DysJipidemia management in adults with diabetes显示文摘 | Haffer SM | 1998 | Diabetes Care1998，21，1： | 1 |
| 16 | Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus 显示文摘 | Haffer SM Greengerg AS Weston WM | 2002 | Circulation2002，106，6： | 1 |
| 17 | Der Schlossbau fruh-heterodonter Lamellibranchiaten aus dcm Rheinischen Devon显示文摘 | HAFFER J | 1959 | PalaeontographicaAbt1959，112，56： | 1 |
| 18 | The insulin resistance syndrome revisited 显示文摘 | Haffer SM | 1996 | Diabetes Care1996，19，： | 1 |
| 19 | Cyclic adenosine monophosphate: possible mediator for norepinephrine effects on cerebellar purkinje cells 显示文摘 | Siggins GH Haffer JH Bloom FE | 1969 | Science1969，165，： | 1 |
| 20 | Der Schlossbau fruh-heterodonter Larnellibranchiaten aus dem Rheinischen Devon 显示文摘 | HAFFER J | 1959 | Palaeontographica Abt1959，112，56： | 1 |
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