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| 1 | Comparison of cytokine and phosphoprotein profiles in idiopathic and Crohn’s disease-related perianal fistula显示文摘BACKGROUND Perianal fistulae are either primary(idiopathic)or secondary[commonly associated with Crohn’s disease,(CD)].It is assumed,although not proven,that the pathophysiology differs.AIM To systematically compare the clinical phenotypes,cytokine and phosphoprotein profiles of idiopathic and CD-related perianal fistulae.METHODS Sixty-one patients undergoing surgery for perianal fistula were prospectively recruited(48 idiopathic,13 CD)into a cohort study.Clinical data,including the Perineal Disease Activity Index(PDAI)and EQ-5D-5L were collected.Biopsies of the fistula tract,granulation tissue,internal opening mucosa and rectal mucosa were obtained at surgery.Concentrations of 30 cytokines and 39 phosphoproteins were measured in each biopsy using a magnetic bead multiplexing instrument and a chemiluminescent antibody array respectively.Over 12000 clinical and 23500 laboratory measurements were made.RESULTS The PDAI was significantly higher(indicating more active disease)in the CD group with a mean difference of 2.40(95%CI:0.52-4.28,P=0.01).Complex pathoanatomy was more prevalent in the CD group,namely more multiple fistulae,supralevator extensions,collections and rectal thickening.The IL-12p70 concentration at the internal opening specimen site was significantly higher(median difference 19.7 pg/mL,99%CI:0.2-40.4,P=0.008)and the IL-1RA/IL-1βratio was significantly lower in the CD group at the internal opening specimen site(median difference 15.0,99%CI=0.4-50.5,P=0.008).However in the remaining 27 cytokines and all 39 of the phosphoproteins across the four biopsy sites,no significant differences were found between the groups.CONCLUSION CD-related perianal fistulae are more clinically severe and anatomically complex than idiopathic perianal fistulae.However,overall there are no major differences in cytokine and phosphoprotein profiles. | James B Haddow Omar Musbahi Thomas T MacDonald Charles H Knowles | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，4： | 2 |
| 2 | Risk-based prenatal screening for trisomy 18using alpha-fetoprotein,unconjugated oestriol and human chorionic gonadotropin显示文摘 | Palomaki GE Knight GJ Haddow JE | 1995 | Prenat Diagn1995，15，： | 1 |
| 3 | A systematic review of the screening accuracy of the HIV Dementia Scale and International HIV Dementia Scale显示文摘 | Haddow LJ Floyd S Copas A | 2013 | PLoS One2013，8，61： | 1 |
| 4 | Maternal thyroid deficiency during pregnancy and subsequent neuropsycho-logical development of the child显示文摘 | Haddow JE Palomaki GE Allan WC | 1999 | N Engl J Med1999，341，： | 1 |
| 5 | Citation analysis and peer ranking of Australian social science journals显示文摘 | Haddow G Genoni P | 2010 | Scientometrics2010，，2： | 1 |
| 6 | Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of thechild显示文摘 | Haddow JE Palomaki GE Allan WC | | 0，，08： | 1 |
| 7 | Challenges of evolvable hardware: past, present and the path to a promising future显示文摘 | Pauline C Haddow Andy M Tyrrell | 2011 | Genetic Programming and Evolvable Machines2011，12，3： | 1 |
| 8 | Screening of maternal serum for fetal Down's syndrome in the first trimester显示文摘 | Haddow JE Paloma KIGE Knight GJ | 1998 | N Engl J Med1998，338，： | 1 |
| 9 | 显示文摘 | Klein RZ Haddow JE Faix JD | 1991 | Clin Endocrinol1991，35，： | 1 |
| 10 | Thyroperoxidase and thyroglobulin antibodies in early pregnancy and preterm delivery 显示文摘 | Haddow JE Cleary - Goldman J McClain MR | 2010 | Obstet Gynecol2010，116，1： | 1 |
| 11 | Maternal thyroid defi- ciency and pregnancy eomplications implications for population screening显示文摘 | Allan WC Haddow JE Palomaki GE | 2000 | Med Screen2000，7，3： | 1 |
| 12 | Prenatal screeningfor Down's syndrome with use of maternal serum markers显示文摘 | Haddow JE Palomaki GE Knight GJ | 1992 | NEngl J Med1992，327，： | 1 |
| 13 | Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child显示文摘 | Haddow JE Palomaki GE Allan WC | | 0，，： | 1 |
| 14 | Screening for Down Syndrome in the United States: Results of Surveys in 2011 and 2012显示文摘 | Palomaki Glenn E Knight George J Ashwood Edward R Best Robert G Haddow James E | 2013 | Archives of Pathology & Laboratory Medicine2013，，7： | 1 |
| 15 | Characterization of sol-gel surfaces for biomedical applications 显示文摘 | HADDOW D B JAMES P F VAN NOORT R | 1996 | Journal of Materials Science: Materials in Medicine1996，7，5： | 1 |
| 16 | Yhyroperoxidase and thyroglobulin antibodies in early pregnancy and preterm delivery显示文摘 | Haddow J E Cleary-Goldman J McClain M R | 2010 | Obstetrics & Gynecology2010，116，1： | 1 |
| 17 | Plane elastic waves generated by dynamical loading applied to edge of circular hole 显示文摘 | MOODIE T B HADDOW J B MIODUCHOWSKI A | 1981 | Journal of Applied Mechanics1981，48，3： | 1 |
| 18 | Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child显示文摘 | Haddow JE Palomaki GE Allan WC et a I | 1999 | N End J Med1999，341，8： | 1 |
| 19 | Is thyroid inadequacyduring gestation a risk factor for adverse pregnancy and development outcomes? 显示文摘 | LaFranchi SH Haddow JE Hollowell JG | 2005 | Thyroid2005，15，1： | 1 |
| 20 | Prenatal screening for Down' s syndrome with use of matemal serum markers显示文摘 | Haddow JE Palomaki GE Knight GJ | 1992 | N Engl J Med1992，327，： | 1 |
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