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| 1 | Calcineurin-B-Like Protein CBL9 Interacts with Target Kinase CIPK3 in the Regulation of ABA Response in Seed Germination显示文摘钙在植物在许多发信号的小径作为第二个送信人起一个重要作用。calcineurin 象 B 一样蛋白质(CBL ) 代表在钙由与他们的交往的蛋白质 kinases (CIPK ) 交往发信号工作的植物钙绑定蛋白质的一个家庭。在我们的以前的学习,我们在骆驼毛的织物发信号为 CBL (CBL9 ) 之一和 CIPK (CIPK3 ) 之一报导了一个角色。这里,我们证明了 CBL9 和 CIPK3 身体上并且机能上地在调整骆驼毛的织物回答与对方一起交往。CBL9 和 CIPK3 蛋白质在酵母与对方一起交往了二混血儿的系统并且当在植物房间表示了时。双变异的 cbl9cipk3 显示出类似的过分敏感的反应到在单个异种(cbl9 或 cipk3 ) 观察了的骆驼毛的织物。CIPK3 的组成地活跃的形式遗传上补充了 cbl9 异种,显示 CIPK3 CBL9 下游地工作。把调查结果基于这些,我们为调整骆驼毛的织物回答在一样的小径一起结束那 CBL9 和 CIPK3 幕。 | Girdhar K. Pandey John J. Grant Yong Hwa Cheong Beom-Gi Kim Le Gong Li Sheng Luan | 2008 | Molecular Plant2008，1，2： | 44 |
| 2 | Electroacupuncture on PC6 Prevents Opioid-Induced Nausea and Vomiting after Laparoscopic Surgery显示文摘Objective:To investigate the treatment time dependence of electroacupuncture(EA) on Neiguan (PC6) for preventing postoperative nausea and vomiting(PONV).Methods:One hundred and seventy-eight patients,who had received intravenous patient-controlled analgesia(PCA) with Fentanyl,were assigned randomly to three groups using random numbers:a pre-operative EA group(PrEA),a post-operative EA group(PoEA),and a non-acupuncture control group(NC).An anesthetist evaluated the incidence and severity of nausea and vomiting for 48 h after surgery blindly.The main outcomes were severity and freguency of PONV,which were measured with a self-reported questionnaire and a confirmation from the anesthetist.The data were analyzed with ANOVA and Z-test.Results:The incidence of nausea and vomiting was significantly lower in the PrEA group than the NC group during 48 h after surgery(P<0.01,P<0.05).The incidence of vomiting was also significantly lower in the PrEA group than the PoEA group(P<0.05).The PoEA subjects evidenced no significant differences compared with the NC subjects in terms of the incidence of nausea and vomiting(P<0.05).The severity of nausea was significantly lower in the PrEA group than in the NC and PoEA groups(P<0.05).Conclusions:EA on PC6 is effective in the prevention of PONV,and pre-operative acupuncture is more effective than post-operative acupuncture. | Siwoo Lee Myeong Soo Lee Deok Hwa Choi Su Kyung Lee | 2013 | Chinese Journal of Integrative Medicine2013，19，4： | 32 |
| 3 | CIPK9: a calcium sensor-interacting protein kinase required for low-potassium tolerance in Arabidopsis显示文摘钾是为在植物的很多个细胞的过程的主要宏营养素必需品之一。在土壤的低钾水平为庄稼生产代表一个限制因子。最近的研究识别了涉及钾获得的钾运输 ers,并且他们中的一些为在低钾条件下面的钾营养是批评的。然而,很少在涉及低钾发信号和回答的分子的部件上被理解。我们这里在 Arabidopsis 作为低钾反应的一个批评管理者报导 calcineurin 象 B 一样交往蛋白质的 proteinkinase (CIPK9 ) 的鉴定。CIPK9 基因对不能生活的压力条件应答,并且它的抄本由钾剥夺在根和射击是可诱导的。CIPK9 功能的混乱使变异的植物变为过分敏感到低钾媒介。进一步的分析显示那 K (+) 举起和内容没在变异的植物被影响,暗示在钾利用的规定的 CIPK9 或察觉到过程。 | Girdhar K Pandey Yong Hwa Cheongx Beom-Gi Kim John J Grant Legong Li Sheng Luan | 2007 | Cell Research2007，17，5： | 23 |
| 4 | The dynamics of the piglet gut microbiome during the weaning transition in association with health and nutrition显示文摘Background: Understanding the composition of the microbial community and its functional capacity during weaning is important for pig production as bacteria play important roles in the pig's health and growth performance. However,limited information is available regarding the composition and function of the gut microbiome of piglets in early-life.Therefore, we performed 16 S rRNA gene and whole metagenome shotgun sequencing of DNA from fecal samples from healthy piglets during weaning to measure microbiome shifts, and to identify the potential contribution of the early-life microbiota in shaping piglet health with a focus on microbial stress responses, carbohydrate and amino acid metabolism.Results: The analysis of 16 S rR NA genes and whole metagenome shotgun sequencing revealed significant compositional and functional differences between the fecal microbiome in nursing and weaned piglets. The fecal microbiome of the nursing piglets showed higher relative abundance of bacteria in the genus Bacteroides with abundant gene families related to the utilization of lactose and galactose. Prevotel a and Lactobacil us were enriched in weaned piglets with an enrichment for the gene families associated with carbohydrate and amino acid metabolism. In addition, an analysis of the functional capacity of the fecal microbiome showed higher abundances of genes associated with heat shock and oxidative stress in the metagenome of weaned piglets compared to nursing piglets.Conclusions: Overal, our data show that microbial shifts and changes in functional capacities of the piglet fecal microbiome resulted in potential reductions in the effects of stress, including dietary changes that occur during weaning.These results provide us with new insights into the piglet gut microbiome that contributes to the growth of the animal. | Robin B.Guevarra Sang Hyun Hong Jin Ho Cho Bo-Ra Kim Jiwon Shin Jun Hyung Lee Bit Na Kang Young Hwa Kim Suphot Wattanaphansak Richard E.Isaacson Minho Song Hyeun Bum Kim | 2018 | Journal of Animal Science and Biotechnology2018，9，4： | 16 |
| 5 | Probucol inhibits LPS-induced microglia activation and ameliorates brain ischemic injury in normal and hyperlipidemic mice显示文摘瞄准:增加的证据建议那 probucol,有抗氧化剂活动的一个类脂化合物阴沉的代理人,可能为有经由在胆固醇和 neuroinflammation 的减小的 hyperlipidemia 的 ischemic 击的治疗有用。在这研究,我们检验了 probucol 是否能在正常和 hyperlipidemic mice.Methods 经由 anti-neuroinflammatory 行动免于大脑 ischemic 损害:主要老鼠 microglia 和鼠科的 BV2 microglia 不为 3 h,和版本暴露于 lipopolysaccharide (LPS ) , PGE2, IL-1β并且在 NF-κ 的 IL-6,以及变化; B,表明小径的 MAPK 和 AP-1 被估计。ApoE 击倒老鼠被喂包含 0.004% 的一本高脂肪的食谱, 0.02% , 0.1%(wt/wt ) 为 10 个星期的 probucol 而正常 C57BL/6J 老鼠收到了 probucol (3, 10, 30 mg· kg -1·d-1, po ) 为 4 d。然后,所有老鼠通过中间的服的动脉吸藏(MCAO ) 受到焦点的服的局部缺血。神经病学的赤字被获得在外科以后的 24 h,然后大脑为测量服的梗塞尺寸和支持 inflammatory mediators.Results 的生产被移开:在对待 LPS 的 BV2 房间和主要 microglial 房间,有 probucol 的预告的处理(1, 5, 10 μ mol/L ) dose-dependently 禁止了版本没有, PGE2, IL-1β并且 IL-6,它发生在抄写铺平。而且, probucol 的禁止的行动与 NF-κ 的 downregulation 被联系;表明小径的 B, MAPK 和 AP-1。在有 MCAO 的正常鼠标, probucol 的管理前 dose-dependently 减少了梗塞卷和改进神经病学的功能。这些效果被支持 inflammatory 调停人的减少的生产伴随(iNOS, COX-2, IL-1, IL-6 ) 。在 ApoE 击倒,老鼠喂了一本高脂肪的食谱, 0.1% probucol 的管理前显著地减少了梗塞体积,改进了跟随 MCAO 的神经病学的赤字,并且减少全部胆固醇并且 LDL 胆固醇 levels.Conclusion:Probucol 禁止导致 LPS 的 microglia 激活并且改善在经由它的 anti-neuroinflammatory 行动的正常和 hyperlipidemic 老鼠的服的 ischemic 损害,建议那 probucol 为 ischemic 击和 hyperlipidemia 为病人的治疗有潜力与或在风险。 | Yeon Suk JUNG Jung Hwa PARK Hyunha KIM So Young KIM Ji Young HWANG Ki Whan HONG Sun Sik BAE Byung Tae CHOI Sae-Won LEE Hwa Kyoung SHIN | 2016 | Acta Pharmacologica Sinica2016，37，8： | 16 |
| 6 | Diagnostic value of maximal-outer-diameter and maximal-mural-thickness in use of ultrasound for acute appendicitis in children显示文摘AIM: To evaluate the maximal-outer-diameter (MOD) and the maximal-mural-thickness (MMT) of the appendix in children with acute appendicitis and to determine their optimal cut-off values to diagnose acute appendicitis. METHODS: In total, 164 appendixes from 160 children between 1 and 17 years old (84 males, 76 females; mean age, 7.38 years) were examined by high-resolution abdominal ultrasound for acute abdominal pain and the suspicion of acute appendicitis. We measured the MOD and the MMT at the thickest point of the appendix. Patients were categorized into two groups according to their medical records: patients who had surgery (surgical appendix group) and patients who did not have surgery (non-surgical appendix group). Data were analyzed by MedCalc v.9.3. The rank sum test (Mann-Whitney test) was used to evaluate the difference in the MOD and the MMT between the two groups. ROC curve analysis was used to determine the optimal cut-off value of the MOD and the MMT on diagnosis of acute appendicitis. RESULTS: There were 121 appendixes (73.8%) in the non-surgical appendix group and 43 appendixes (26.2%) in the surgical appendix group. The median MOD differed significantly between the two groups (0.37 cm vs 0.76 cm, P < 0.0001), and the median MMT also differed (0.15 cm vs 0.33 cm, P < 0.0001). The optimal cut-off value of the MOD and the MMT for diagnosis of acute appendicitis in children was > 0.57 cm (sensitivity 95.4%, specificity 93.4%) and > 0.22 cm (sensitivity 90.7%, specificity 79.3%), respectively. CONCLUSION: The MOD and the MMT are reliable criteria to diagnose acute appendicitis in children. An MOD > 0.57 cm and an MMT > 0.22 cm are the optimal criteria. | Bo-Kyung Je Sung-Bum Kim Seung Hwa Lee Ki Yeol Lee Sang Hoon Cha | 2009 | World Journal of Gastroenterology2009，15，23： | 14 |
| 7 | Preliminary experience with drug-coated balloon angioplasty in primary percutaneous coronary intervention显示文摘We evaluated the clinical feasibility of using drugcoated balloon(DCB) angioplasty in patients undergoingprimary percutaneous coronary intervention(PPCI). Between January 2010 to September 2014,89 STelevation myocardial infarction patients(83% male,mean age 59 ± 14 years) with a total of 89 coronary lesions were treated with DCB during PPCI. Clinical outcomes are reported at 30 d follow-up. Left anterior descending artery was the most common target vessel for PCI(37%). Twenty-eight percent of the patients had underlying diabetes mellitus. Mean left ventricular ejection fraction was 44% ± 11%. DCB-only PCI was the predominant approach(96%) with the remaining 4% of patients receiving bail-out stenting. Thrombolysis in Myocardial Infarction(TIMI) 3 flow was successfully restored in 98% of patients. An average of 1.2 ± 0.5 DCB were used per patient,with mean DCB diameter of 2.6 ± 0.5 mm and average length of 23.2 ± 10.2 mm. At 30-d follow-up,there were 4 deaths(4.5%). No patients experienced abrupt closure of the infarctrelated artery and there was no reported target-lesion failure. Our preliminary experience showed that DCB angioplasty in PPCI was feasible and associated with a high rate of TIMI 3 flow and low 30-d ischaemic event. | Hee Hwa Ho Julian Tan Yau Wei Ooi Kwok Kong Loh Than Htike Aung Nwe Tun Yin Dasdo Antonius Sinaga Fahim Haider Jafary Paul Jau Lueng Ong | 2015 | World Journal of Cardiology2015，7，6： | 14 |
| 8 | 尖锐心肌的梗塞: 在在新加坡的年轻成年人的临床的特征和结果显示文摘 AIM: To investigate the clinical features and in-hospital outcomes of young adults with acute myocardial infarction (AMI) in Singapore. METHODS: Between January 2005 to September 2010, 333 consecutive patients aged ≤ 45 years old were diagnosed to have AMI at our institution. As Singapore is a multi-ethnic society, we also analysed whether ethnic differences exist between the three dominant ethnic groups, Malay, Chinese and Indian with regards to the clinical features. Clinical data was collected retrospectively on demographic characteristics, presenting signs and symptoms, blood investigation, angiographic findings and in-hospital clinical outcomes. RESULTS: The mean age at presentation was 40.2 ± 4.0 years with male predominance (94%). The majority of patients were Chinese (51%) followed by Indians (31%) and Malays (18%). The most common risk factor was smoking (74%) followed by hypertension (28.5%) and hyperlipidemia (20.0%). 37% of patients were obese. The majority of patients had single vessel disease (46%) on coronary angiography. The mean total cholesterol, low-density lipoprotein and highdensity lipoprotein levels were 5.6±1.2 mmol/L, 3.8±1.1 mmol/L and 0.93±0.25 mmol/L respectively. The mean left ventricular function was 44%±10% with the incidence of heart failure 3% and cardiogenic shock 4.5%. Overall in-hospital mortality was low with 4 deaths (1.2%). For ethnic subgroup analysis, Indians have a 3-fold risk of developing premature AMI when compared to other ethnic groups. CONCLUSION: Young AMI patients in Singapore are characterized by male predominance, high incidence of smoking and obesity. Overall in-hospital clinical outcomes are favourable. Among the 3 ethnic groups, Indians have the highest risk of developing premature AMI. | Chun Pong Wong Seet Yoong Loh Kwok Kong Loh Paul Jau Lueng Ong David Foo Hee Hwa Ho | 2012 | World Journal of Cardiology2012，4，6： | 13 |
| 9 | Cardioprotective mechanism of SGLT2 inhibitor against myocardial infarction is through reduction of autosis显示文摘Sodium-glucose cotransporter 2(SGLT2)inhibitors reduce cardiovascular mortality in patients with diabetes mellitus but the protective mechanism remains elusive.Here we demonstrated that the SGLT2 inhibitor,Empagliflozin(EMPA),suppresses cardiomyocytes autosis(autophagic cell death)to confer cardioprotective effects.Using myocardial infarction(Ml)mouse models with and without diabetes mellitus,EMPA treatment significantly reduced infarct size,and myocardial fibrosis,thereby leading to improved cardiac function and survival.In the context of ischemia and nutritional glucose deprivation where autosis is already highly stimulated,EMPA directly inhibits the activity of the Na^(+)/H^(+)exchanger 1(NHE1)in the cardiomyocytes to regulate excessive autophagy.Knockdown of NHE1 significantly rescued glucose deprivation-induced autosis.In contrast,overexpression of NHE1 aggravated the cardiomyocytes death in response to starvation,which was effectively rescued by EMPA treatment.Furthermore,in vitro and in vivo analysis of NHE1 and Beclin 1 knockout mice validated that EMPA s cardioprotective effects are at least in part through downregulation of autophagic flux.These findings provide new insights for drug development,specifically targeting NHE1 and autosis for ventricular remodeling and heart failure after Ml in both diabetic and non-diabetic patients. | Kai Jiang Yue Xu Dandan Wang Feng Chen Zizhuo Tu Jie Qian Sheng Xu Yixiang Xu John Hwa Jian Li Hongcai Shang Yaozu Xiang | 2022 | Protein & Cell2022，13，5： | 13 |
| 10 | Effect of Korean red ginseng on blood pressure and nitric oxide production显示文摘AIM: To investigate the effect of crude saponin and non-saponin fraction of Korean red ginseng (KRG) on the blood pressure and nitric oxide (NO) production in the conscious rats and cultured endothelial cell line, ECV 304 cells. METHODS: Systolic blood pressure and heart rate were monitored in the conscious rats. Nitric oxide levels and the expression of nitric oxide synthase were measured by a spectrophotometric assay using Griess reagents and Western blotting, respectively. Nitric-oxide synthase activity was measured based on the conversion rate of [3H]arginine to [3H]citrulline. RESULTS: Systolic blood pressure was decreased by crude saponin (100 mg/kg, iv) of KRG in the conscious control and one-kidney, one-clip Goldblatt hypertensive (IK, 1C-GBH) rats. The hypotensive effect induced by crude saponin of KRG reached maximum at 2 - 4 min and slowly recovered after 20 min to the initial level in both groups. Crude saponin of KRG induced tachycardia in the conscious rats but induced bradycardia in the | JEON Byeong Hwa KIM Cuk Seong KIM Hoe-Suk PARK Jin-Bong NAM Ki Yeul CHANG Seok Jong | 2000 | Acta Pharmacologica Sinica2000，21，12： | 12 |
| 11 | 在孩子的正常和反常附录的 Ultrasonography显示文摘 Appendicitis is the most common acute surgical emergency of childhood. Since the original report by Puylaert in 1986, the use of ultrasonography in the diagnosis of appendicitis has been the subject of considerable study. Among the reported diagnostic criteria, the maximal outer diameter (MOD) of the appendix is accepted as the one of the most reliable criteria used to differentiate between a normal appendix and acute appendicitis. However, MOD measurement is subject to inaccuracies because luminal distention by non-compressible, non-inflammatory material such as fecal material, or increased maximal mural thickness due to reactive mucosal lym-phoid hyperplasia, or a medical cause due to a generalized gastrointestinal disease, such as Crohn’s disease, can cause the measurement to exceed the upper limits of normality. The aim of this article is to introduce the spectrum of ultrasonographic findings in the normal andabnormal appendix and eventually to reduce unneces-sary surgery in children. | Noh Hyuck Park Hwa Eun Oh Hee Jin Park Ji Yeon Park | 2011 | World Journal of Radiology2011，3，4： | 11 |
| 12 | Ethanolic extract of dandelion(Taraxacum mongolicum) induces estrogenic activity in MCF-7 cells and immature rats显示文摘Plants of the genus Taraxacum, commonly known as dandelions, are used to treat breast cancer in traditional folk medicine. However, their use has mainly been based on empirical findings without sufficient scientific evidence. Therefore, we hypothesized that dandelions would behave as a Selective estrogen receptor modulator(SERM) and be effective as hormone replacement therapy(HRT) in the postmenopausal women. In the present study, in vitro assay systems, including cell proliferation assay, reporter gene assay, and RT-PCR to evaluate the m RNA expression of estrogen-related genes(p S2 and progesterone receptor, PR), were performed in human breast cancer cells. Dandelion ethanol extract(DEE) significantly increased cell proliferation and estrogen response element(ERE)-driven luciferase activity. DEE significantly induced the expression of estrogen related genes such as p S2 and PR, which was inhibited by tamoxifen at 1 μmol·L-1. These results indicated that DEE could induce estrogenic activities mediated by a classical estrogen receptor pathway. In addition, immature rat uterotrophic assay was carried out to identify estrogenic activity of DEE in vivo. The lowest concentration of DEE slightly increased the uterine wet weight, but there was no significant effect with the highest concentration of DEE. The results demonstrate the potential estrogenic activities of DEE, providing scientific evidence supporting their use in traditional medicine. | Seung Min Oh Ha Ryong Kim Yong Joo Park Yong Hwa Lee Kyu Hyuck Chung | 2015 | Chinese Journal of Natural Medicines2015，13，11： | 11 |
| 13 | Effect of Korea red ginseng on cerebral blood flow and superoxide production显示文摘AIM:To investigate the effects of Korea red ginsng(KRG) on the cerebral perfusion rate in the rats and the generation of superoxide anion in the endothelial cells.METHODS:The cerebral perfusion rate was measured using laser-doppler flowmetry before and after the administration of crude saponin(CS) and saponin-free fraction (SFF) of ERG in the anesthetized rats.The superoxide generation was measured by the method based on lucigeninenhanced chemiluminescence in the cultured endothelial cells.RESULTS:The relative cerebral perfusion rate (rCBF) was significantly increased by the intraperitoneal injection of CS(100mg/kg) in the rats,but SFF had no effect on the rCBF.Chronic treatment with CS for 7d significantly inhibited the decrease of forebrain cerebral blood frow induced by clamping both carotid arteries in the rats.Furthermore,CS(0.1g/L) significantly suppressed NADPH-induced superoxide generation in the human umbilical vein endothelial cells(P<0.01).CONCLUSION:The present study demonstrated that crude saponin fraction of KRG enhanced cerebral blood flow in rats.Furthermore,crude saponin fraction of KRG abrogated the NADPH-driven superoxide generation in endothelial cells. | CukSeong KIM Jin Bong PARK Kwang-Jin KIM Seok Jong CHANG Sung-Woo RYOO Byeong Hwa JEON | 2002 | Acta Pharmacologica Sinica2002，23，12： | 11 |
| 14 | SnO2@Co3O4 hollow nano-spheres for a Li-ion battery anode with extraordinary performance显示文摘 | Won-Sik Kim Yoon Hwa Hong-Chan Kim Jong-Hyun Choi Hun-Joon Sohn Seong-Hyeon Hong | 2014 | Nano Research2014，7，8： | 11 |
| 15 | Delayed hypersensitivity reaction resulting in maculopapular-type eruption due to entecavir in the treatment of chronic hepatitis B显示文摘Several clinical trials have demonstrated the potent antiviral efficacy of entecavir(ETV), and this relatively new nucleoside analogue drug has rapidly become a frequently prescribed therapy for chronic hepatitis B(CHB) worldwide. While the studies have also shown a good overall safety profile for ETV, adverse drug reactions(ADRs) in patients with advanced cirrhosis have been reported and represent a broad spectrum of drug-induced injuries, including lactic acidosis, myalgia, neuropathy, azotemia, hypophosphatemia, muscular weakness, and pancreatitis, as well as immunemediated responses(i.e., allergic reactions). Cutaneous ADRs associated with ETV are very rare, with only two case reports in the publicly available literature; both of these cases were classified as unspecified hypersensitivity allergic(type I) ADR, but neither were reported as pathologically proven or as evaluated by cytokine release analysis. Here, we report the case of a 45-yearold woman who presented with a generalized maculopapular rash after one week of ETV treatment for lamivudine-resistant CHB. The patient reported having experienced a similar skin eruption during a previous three-month regimen of ETV, for which she had selfdiscontinued the medication. Histopathological analysis of a skin biopsy showed acanthotic epidermis with focal parakeratosis and a perivascular lymphocytic infiltrate admixed with interstitial eosinophils in the papillary and reticular dermis, consistent with a diagnosis of drug sensitivity. A lymphocyte stimulation test showed significantly enhanced IL-4, indicating a classification of type Ⅳb delayed hypersensitivity. The patient was switched to an adefovir-lamivudine combination regimen and the skin eruption resolved two weeks after the ETV withdrawal. This case represents the first pathologically and immunologically evidenced ETV-induced delayed type hypersensitivity skin reaction reported to date. Physicians should be aware of the potential, although rare, for cutaneous ADRs associated with ETV treatment. | Jeong Tae Kim Hye Won Jeong Ki Hwa Choi Tae Young Yoon Nohyun Sung Young Ki Choi Eun Ha Kim Hee Bok Chae | 2014 | World Journal of Gastroenterology2014，20，42： | 10 |
| 16 | Circulating miRNAs in Ageing and Ageing-Related Diseases显示文摘MicroRNAs(miRNAs) are small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level.They are involved in important biological processes including development,homeostasis,and ageing.Recently,extracellular miRNAs have been discovered in the bloodstream and bodily fluids.These miRNAs are shown to be secreted and circulating in microvesicles(MVs),or in complex with other factors such as RNA-binding proteins and high-density lipoprotein(HDL) particles.These cell-free,circulating miRNAs can be taken into and function as negative regulators of target genes in recipient cells.Here we review the biogenesis and uptake of circulating miRNAs as well as their profiles in ageing and ageing-related diseases.We discuss the emerging role of circulating miRNAs as biomarkers and therapeutic targets. | Hwa Jin Jung Yousin Suh | 2014 | Journal of Genetics and Genomics2014，41，9： | 9 |
| 17 | 北京地区单双频地基GPS大气水汽遥测试验与研究显示文摘该文对北京地区单双频地基GPS大气水汽监测网布网依据、单频与双频地基GPS测量数据解算技术应用、GAMIT和Bernese地基GPS数据分析处理软件应用、远程遥控GPS数据采集与通讯系统、资料分析与数值同化应用等方面的工作进展进行简要介绍,重点讨论了单双频地基GPS大气水汽资料的解算技术及其应用效果。结果表明:在北京天气敏感区通过单双频地基GPS接收机合理组网布局,可构建并利用高分辨率电离层延迟订正技术将单频接收机的大气水汽监测精度提高到实用水平,为强降水天气预报提供有价值的产品。 | 谢璞 张朝林 王迎春 楚艳丽 张京江 王京丽 李矩 Ying Hwa Kuo John Braun | 2006 | 应用气象学报2006，17，B08： | 9 |
| 18 | Clinicopathologic factors influencing the accuracy of EUS for superficial esophageal carcinoma显示文摘AIM:To identify clinicopathologic factors influencing the accuracy of a high-frequency catheter probe endoscopic ultrasonography(EUS)for superficial esophageal carcinomas(SECs).METHODS:A total of 126 patients with endoscopically suspected SEC,who underwent EUS and curative treatment at Pusan National University Hospital during2005-2013,were enrolled.We reviewed the medical records of the 126 patients and compared EUS findings with histopathologic results according to clinicopathologic factors.RESULTS:A total of 114 lesions in 113 patients were included in the final analysis.The EUS assessment of tumor invasion depth was accurate in 78.9%(90/114)patients.Accuracy did not differ according to histologic type,tumor differentiation,tumor location,or macroscopic shape.However,accuracy significantly decreased for tumors≥3 cm in size(P=0.002).Overestimation and underestimation of the invasion depth occurred for 11(9.6%)and 13 lesions(11.4%),respectively.In multivariate analyses,tumor size≥3 cm was the only factor significantly associated with EUS accuracy(P=0.031),and was specifically associated with the underestimation of invasion depth.CONCLUSION:EUS using a high-frequency catheter probe generally provides highly accurate assessments of SEC invasion depth,but its accuracy decreases for tumors≥3 cm. | Jung Im Jung Gwang Ha Kim Hoseok I Do Youn Park Tae Kyun Kim Young Hwa Cho Yong Wan Sung Mun Ki Choi Bong Eun Lee Geun Am Song | 2014 | World Journal of Gastroenterology2014，20，20： | 9 |
| 19 | Hepatic artery pseudoaneurysm caused by acute idiopathic pancreatitis显示文摘Hepatic artery pseudoaneurysm(HAP) is a very rare disease but in cases of complication,there is a very high mortality.The most common cause of HAP is iatrogenic trauma such as liver biopsy,transhepatic biliary drainage,cholecystectomy and hepatectomy.HAP may also occur with complications such as infections or inflammation associated with septic emboli.HAP has been reported rarely in patients with acute pancreatitis.As far as we are aware,there is no report of a case caused by acute idiopathic pancreatitis,particularly.We report a case of HAP caused by acute idiopathic pancreatitis which developed in a 61-year-old woman.The woman initially presented with acute pancreatitis due to unknown cause.After conservative management,her symptoms seemed to have improved.But eight days after admission,abdominal pain abruptly became worse again.Abdominal computed tomography(CT) was rechecked and it detected a new HAP that was not seen in a previous abdominal CT.Endoscopic retrograde cholangiopancreatography(ERCP) was performed because of a suspicion of hemobilia as a cause of aggravated abdominal pain.ERCP confirmed hemobilia by observing fresh blood clots at the opening of the ampulla and several filling defects in the distal common bile duct on cholangiogram.Without any particular treatment such as embolization or surgical ligation,HAP thrombosed spontaneously.Three months after discharge,abdominal CT demonstrated that HAP in the left lateral segment had disappeared. | Yeon Hwa Yu Joo Hyun Sohn Tae Yeob Kim Jae Yoon Jeong Dong Soo Han Yong Cheol Jeon Min Young Kim | 2012 | World Journal of Gastroenterology2012，18，18： | 8 |
| 20 | Clinical significance of hepatitis B e antigen level measurement during long-term lamivudine therapy in chronic hepatitis B patients with e antigen positive显示文摘AIM: To determine the changes of quantitative hepatitis B e antigen (HBeAg) that predicts early detection of non- response or breakthrough to long-term lamivudine (LAM) therapy.METHODS: Among HBeAg positive chronic hepatitis B patients who failed to achieve HBeAg seroconversion within 12 mo, we retrospectively analyzed 220 patients who had received LAM more than 24 mo. RESULTS: The mean duration of LAM therapy was 36 (range, 24-72) mo. HBeAg seroconversion after the first 12 mo of LAM therapy was achieved in 53 (24.1%) patients. Viral breakthrough was observed in 105 (47.7%) patients. To find out whether the changing patterns of HBeAg levels can predict the outcome of LAM therapy, we analyzed the reduction rates of HBeAg levels during LAM therapy. Using the decrease more than 90% of pretreatment HBeAg levels, the sensitivity and specificity of response were 96.2% and 70.1%, respectively. Patients were divided into 3 groups according to the reduction patterns of the decrease of quantitative HBeAg: decrescendo, decrescendo-crescendo, no change or fluctuating groups. The optimal time to predict non- response or breakthrough was the first 9 mo of therapy. At 9 mo of therapy, 49 (92.5%) of 53 patients who had achieved HBeAg seroconversion were included in the decrescendo group. On the contrary, in the no change or fluctuating group, only four (7.5%) had achieved HBeAg seroconversion. Among patients who did not show the continuous decrease of HBeAg levels at 9 mo, 95.2% (negative predictive value) failed to achieve HBeAg seroconversion.CONCLUSION: Almost all patients who failed to showa continuous decrease of HBeAg levels at 9 mo of LAM therapy were non-response or breakthrough. Therefore, monitoring changes of HBeAg levels during LAM therapy in HBeAg positive chronic hepatitis B may be valuable for identifying patients who are at high risk of non-response or breakthrough. | Jung Woo Shin Neung Hwa Park Seok Won Jung Byung Chul Kim Sung Ho Kwon Jae Serk Park In Du Jeong Sung-Jo Bang Do Ha Kim | 2006 | World Journal of Gastroenterology2006，12，41： | 7 |
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