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| 1 | Kappa coefficient: a popular measure of rater agreement显示文摘 | Wan TANG Jun HU HuiZHANG Pan WU Hua HE | 2015 | 上海精神医学2015，27，1： | 37 |
| 2 | Incidence and mortality of thyroid cancer in China, 2008-2012显示文摘Objective: To analyze the incidence and mortality rates of thyroid cancer(TC) in China from 2008 to 2012.Methods: Incident and death cases of TC were retrieved from the National Central Cancer Registry(NCCR)database collecting from 135 cancer registries in China during 2008-2012. The crude incidence and mortality rates of TC were calculated by area(urban/rural), region(eastern, middle, western), gender and age group(0, 1-4, 5-9,…, 85+). China census in 2000 and world Segi's population were applied for age-standardized rates. Joinpoint(Version 4.6.0.0) model was used for time-trend analysis.Results: The crude incidence rate of TC was 7.56/100,000 which ranked the seventh in overall cancers. The agestandardized incidence rates by China population(ASIRC) and by World population(ASIRW) were 6.25/100,000 and 5.52/100,000, respectively. The crude mortality of TC in China was 0.52/100,000. The age-standardized mortality rates by Chinese standard population(ASMRC) and by world standard population(ASMRW) were0.34/100,000 and 0.32/100,000, respectively. Incidence and mortality rates of TC were higher in females than in males and higher in urban areas than in rural areas. Eastern areas had the highest incidence followed by middle and western areas. TC incidence increased dramatically after age of 15 years, then peaked at 14.08/100,000 in the group of 50-54 years and finally decreased sharply after 55 years old. TC mortality increased with age in population,reaching the peak of 5.09/100,000 in sub-population aged 85 years or older. TC incidence increased by 4.73 times from 2.40/100,000 in 2003 to 13.75/100,000 in 2012 with an average annual increase of 20%, while TC mortality only increased slightly around 0.32/100,000 from 0.26/100,000 to 0.36/100,000.Conclusions: Appropriate targeted prevention, early detection and treatment programs can be carried out to curb the rapid growth trend of TC and control the disease burden. | Lingbin Du Runhua Li Minghua Ge Youqing Wang Huizhang Li Wanqing Chen Jie He | 2019 | Chinese Journal of Cancer Research2019，31，1： | 31 |
| 3 | Incidence and mortality of laryngeal cancer in China, 2011显示文摘Objective: Laryngeal cancer is the common cancer of the upper aerodigestive tract. We aimed to use the national cancer registration data in 2011 to estimate the incidence and mortality of laryngeal cancer within China.Methods: Comparable, high-quality data from 177 population-based cancer registries were qualified for analysis. The pooled data were stratified by area, sex and age group. National new cases and deaths of laryngeal cancer were estimated using age-specific rates and national population in 2010. All incidence and death rates were age-standardized to the 2000 Chinese standard population and Segi's population, which were expressed per 100,000 populations.Results: All 177 cancer registries covered a total of 175,310,169 population(98,341,507 in urban and 76,968,662 in rural areas), accounting for 13.01% of the national population. The data quality indicators of proportion of morphological verification(MV%), percentage of cancer cases identified with death certification only(DCO%) and mortality to incidence ratio(M/I) were 77.98%, 2.62% and 0.55, respectively. Estimated 20,875 new cases of laryngeal cancer were diagnosed and 11,488 deaths from laryngeal cancer occurred in China in 2011. The crude incidence rate of laryngeal cancer was 1.55/100,000(2.69/100,000 in males and 0.35/100,000 in females). Age-standardized incidence rates by Chinese standard population(ASIRC) and by world standard population(ASIRW) were 1.13/100,000 and 1.14/100,000, respectively. Laryngeal cancer is much rarer in females than in males. The incidence rate was higher in urban areas than that in rural areas. The crude mortality rate of laryngeal cancer was 0.85/100,000(1.42/100,000 in males and 0.25/100,000 in females). Age-standardized mortality rates by Chinese standard population(ASMRC) and by world standard population(ASMRW) were both 0.61/100,000. The mortality rate in males was much higher than that in females. There was no definite difference in mortality rates of laryngeal cancer between urban and rural areas.Conclusions: Larynx is a specialized area and cancer of larynx significantly affects the quality of life for the patients. Comprehensive measures should be carried out to prevent the ascent of laryngeal cancer. | Lingbin Du Huizhang Li Chen Zhu Rongshou Zheng Siwei Zhang Wanqing Chen | 2015 | Chinese Journal of Cancer Research2015，27，1： | 29 |
| 4 | Transabdominal ultrasonography in preoperative staging of gastric cancer显示文摘AIM: To investigate the value of transabdominal ulbasonography (US) in the preoperative staging of gastric cancer.METHODS: A total of 198 patients with gastric cancer underwent preoperatively transabdominal US, depth of tumor infiltration was assessed in 125 patients, and lymph node metastasis was assessed in 106 patients,RESULTS: The staging accuracy of transabdominal US was 55.6%, 75.0%, 87.3% and 71.1% in T1, T2, T3 and T4 carcinomas, respectively. The overall accuracy was 77.6%.The detection rate for pancreatic invasion and liver invasion was 77.4%, 71.4%, respectively. The sensitivity, specificity,accuracy of transabdominal US in assessment of lymph node metastasis were 77.6%, 64.1%, 72.6%, respectively.Various shapes such as round, ovoid, spindle were encountered in benign and malignant lymph nodes. Majority of boa benign and malignant lymph nodes were hyperechoic and had a distinct border. Benign lymph nodes were smaller than malignant lymph nodes in length and width (P = 0.000,0.005). Irregular shape, fusional shape, infiltrative signs,inhomogenous echo were seen mainly in malignant lymph nodes (P = 0.045, 0.006, 0.027, 0.006).CONCLUSION: Transabdominal US is useful for preoperative staging in gastric cancer, although it is difficult to differentiate benign from malignant lymph nodes. | Sheng-RiLiao YingDai LingHuo KunYan LinZhang HuiZhang WenGao Min-HuaChen | 2004 | World Journal of Gastroenterology2004，10，23： | 18 |
| 5 | Different contributions of STAT3, ERK1/2, and PI3-K signaling to cardiomyocyte hypertrophy by cardiotrophin-1显示文摘AIM: To assess the contribution of signal transducer and activator of transcription 3(JAK-STAT3) pathway, extracellular signal-regulated kinases1/2 (ERK1/2) pathway, and phosphatidylinositol 3-kinase (PI3-K) pathway to cardiomyocytes hypertrophy induced by cardiotrophin-1 (CT-1), a new member of interleukin-6 (IL-6) family of cytokines. METHODS: STAT3, ERK1/2, and PI3-K were assessed by Western blot analysis. Activity of ERK1/2 was also confirmed by in-gel kinase assay. Hypertrophy of cardiomyocyte was evaluated by [^3H]leucine incorporation and cellular protein-to-DNA ratio. RESULTS: CT-1 simultaneously activated phosphorylation of STAT3, ERK1/2, and PI3-K in rat cardiomyocytes. Parthenolide, an inhibitor of STAT, suppressed CT-1-induced [^3H]leucine incorporation by 88.3% and protein-to-DNA ratio by 75.0%. U0126, an MEK1/2 inhibitor, increased CT-1-induced the phosphorylation of STAT3 in a dose-dependent manner and, consistently, augmented CT-1-induced increase in [^3H]leucine incorporation and cellular protein-to-DNA ratio by 17.6% and 16.3%, respectively. Wortmannin, a PI3-K inhibitor, did not influence CT-1-induced [^3H]leucine incorporation and cellular protein-to-DNA ratio. CONCLUSION: The hypertrophic effect of CT-1 was essentially mediated by STAT3, independent of PI3-K, and negatively regulated by ERK1/2 via inhibiting the phosphorylation of STAT3. The interaction between STAT3 and ERK1/2 in CT-1-induced signaling contributes to development of cardiac hypertrophy. | Ze-junTIAN WeiCUI Yong-junLI Yu-mingHAO JunDU FanLIU HuiZHANG Xiu-guangZU Su-yunLIU LiCHEN WeiAN | 2004 | Acta Pharmacologica Sinica2004，25，9： | 16 |
| 6 | Role of Contrast Enhanced Ultrasound in Radiofrequency Ablation of Metastatic Liver Carcinoma显示文摘Objective:To investigate the application of contrast enhanced ultrasound(CEUS) in planning and guiding for radiofrequency ablation(RFA) for metastatic liver carcinoma(MLC).Methods:One hundred and thirty-five patients with clinically and pathologically diagnosed MLC(from gastrointestinal tumors) were included in the present study,and 104 of them had received CEUS prior to RFA to assess the number,size,shape,infiltration,location and enhancing features of the lesions.Among the 104 patients,21(20.1%) were excluded from RFA treatment due to too many lesions or large infiltrative range based on CEUS.The remaining 83 patients with 147 lesions underwent RFA(group A).During the same period,other 31 patients with 102 lesions serving as control group were treated based on findings of conventional ultrasound without contrast(group B).The patients underwent follow-up enhanced CT at the 1st month,and then every 3-6 months after RFA.The tumor was considered as early necrosis if no contrast enhancement was detected in the treated area on the CT scan at the 1st month.Results:In group A,72 of 147 MLC lesions(48.9%) showed increased sizes on CEUS.Among them,48 lesions(66.6%) appeared enlarged in arterial phase,and 24(33.3%) showed enlarged hypoechoic area in parenchymal phase.CEUS showed total 61 additional lesions in 35 patients(42.1%)(ranged from 8 to 15 mm) compared with conventional ultrasound(US),and 42(68.8%) of them were visualized in parenchymal phase only.There were total 208 lesions in group A underwent RFA with CEUS planning,and the tumor necrosis rate was 94.2%(196/208).In this group,local recurrence was found in 16 lesions(7.7%) during 3-42 months' following up,and new metastases were seen in 30 cases(36.1%).For group B,the tumor necrosis rate was 86.3%(88/102),local recurrence in 17 lesions(16.7%),and new metastases in 13 cases(41.9%).Tumor early necrosis and recurrence rates were significantly different between the two groups(P=0.018,P=0.016,respectively).Conclusion: CEUS played an important role in RFA for liver metastases by candidate selecting and therapy planning, which helped to improve the outcome of the treatment. | Jin-yu Wu Min-hua Chen Wei Yang Shu-zhi Lin Wei Wu Shan-shan Yin HuiZhang Kun Yan | 2012 | Chinese Journal of Cancer Research2012，24，1： | 11 |
| 7 | Realistic Modeling and Animation of Human Body Based on Scanned Data显示文摘In this paper we propose a novel method for building animation model of real human body from surface scanned data.The human model is represented by a triangular mesh and described as a layered geometric model.The model consists of two layers: the control skeleton generating body animation from motion capture data,and the simplified surface model providing an efficient representation of the skin surface shape.The skeleton is generated automatically from surface scanned data using the feature extraction,and thena point-to-line mapping is used to map the surface model onto the underlying skeleton.The resulting model enables real-time and smooth animation by manipulation of the skeleton while maintaining the surface detail.Compared with earlier approach,the principal advantages of our approach are the automated generation of body control skeletons from the scanned data for real-time animation,and the automatic mapping and animation of the captured human surface shape.The human model constructed in this work can be used for applications of ergonomic design,garment CAD,real-time simulating humans in virtual reality environment and so on. | Yong-YouMa HuiZhang Shou-WeiJiang | 2004 | Journal of Computer Science & Technology2004，19，4： | 6 |
| 8 | Toxicity of novel anti-hepatitis drug bicyclol: A preclinical study显示文摘AIM: To study the toxicity of bicyclol to animals.METHODS: Acute toxicity test was performed in Kunming strain mice that were orally given bicyclol at the doses of 3 and 5 g/kg body weight, respectively. Wistar rats were orally administered bicyclol at a dose of 5 g/kg body weight. Death and clinical symptoms of animals were recorded within 7 d. Sub-acute toxicity test was carried out in rats that were treated with various doses of bicyclol (150, 300, 600 mg/kg) once daily for 14 d.Animal behaviors, blood biochemical markers, blood and urine pictures were examined. Chronic toxicity test was conducted in 80 Wistar rats of both sexes. The animals were orally administered with various doses of bicyclol[150, 300, 600 mg/kg, 100-400 folds corresponding to for patients] once daily for 6 mo except for Sunday. The control group was given the same volume of 0.2%sodium carboxyl methylcellulose (Na-CMC). Twenty-one beagle dogs received bicyclol (25, 75, 225 mg/kg, 16.6,50, 150 folds corresponding to the proposed therapeutic dose of bicyclol for patients) once a day for 6 mo except for Sunday. The body weight, food intake, urine and feces, blood picture, blood biochemical markers, and pathological examination of main organs were determined. Mutagenicity and teratogenicity were determined. Mutagenicity assay included Ames's test, chromosome aberration test in CHL cells and micronucleus test in mice. For the teratogenicity assay, pregnant Wistar rats weighing 200-250 g were treated with 0.2, 1.0 g/kg bicyclol once daily from the 7th d of gestation for 10 d.RESULTS: The oral LD50 of bicyclol was over 5 g/kg in mice and rats. No noticeable alterations in subacute and chronic toxicity of rats and dogs were demonstrated. No mutagenicity and teratogenicity of bicyclol were found.CONCLUSION: Bicyclol has no detectable chronic toxicity as well as mutagenicity and teratogenicity in animals. | Geng-TaoLiu YanLi Huai-LingWei HongLu HuiZhang Yu-GuiGao Ling-ZhiWang | 2005 | World Journal of Gastroenterology2005，11，5： | 5 |
| 9 | Fabrication of chiral plasmonic oligomers using cysteine-modified gold nanorods as monomers显示文摘在紫外区域以外的圆形的二色性(CD ) 的产生具有对开发 chiral 传感器和 chiroptical 设备的大兴趣。此处,我们在可见、近的红外与强壮的 CD 反应为 plasmonic oligomers 的制造表明一个简单、万用的方法光谱范围。oligomers 被被触发制作一起修改半胱氨酸的金 nanorods 的汇编。修改 nanorods 自己没展出明显的 plasmonic CD 信号;然而, oligomers 表演在电浆子回声波长附近的强壮的 CD 乐队。CD 乐队的符号被吸收半胱氨酸分子的 chirality 支配。由调整 oligomers, chiral 分子的集中,或 nanorods 的方面比率的尺寸, CD 紧张并且光谱范围是容易地悦耳的。理论计算建议 oligomers 的那 CD 在 oligomer 以内从邻近的 nanorods 的细微扭曲发源。因此,我们建议吸附的 chiral 分子能操作在 nanorods 之间的扭曲角度并且因此调制 oligomers 的 CD 反应。 | Shuai Hou Tao Wen HuiZhang Wenqi Liu Xiaona Hu Rongyao Wang Zhijian Hu Xiaochun Wu | 2014 | Nano Research2014，7，11： | 4 |
| 10 | Efficient image representation for object recognition via pivots selection显示文摘 | Bojun XIE Yi LIU HuiZHANG Jian YU | 2015 | Frontiers of Computer Science2015，9，3： | 3 |
| 11 | Thermal-Mechanical Fatigue Behavior and Life Analysis of Cast Ni-base Superalloy K417显示文摘In-phase (IP) and out-of-phase (OP) thermal-mechanical fatigue (TMF) behavior of cast Ni-base superalloy K417 was studied. All experiments were carried out under total strain control with temperature cycling between 400-850℃. Both in-phase and out-of-phase TMF specimens exhibited cyclic hardening followed by cyclic softening at the minimum temperature. Besides, they cyclically hardened in the early stage of life followed by cyclic softening at the maximum temperature. OP TMF life was longer than that of IP TMF. Various damage mechanisms operating in different controlled strain ranges and phasing were discussed. A few life prediction methods for isothermal fatigue were used to handle TMF fatigue and their applicability to superalloy K417 was evaluated. The SEM analysis of the fracture surface showed that transgranular fracture was the principal cracking mode for both IP and OP TMF. Oxidation was the main damage mechanism in causing shorter fatigue life for IP TMF compared with OP TMF. | HuiZHANG YuechenWANG 等 | 2002 | Journal of Materials Science & Technology2002，18，2： | 2 |
| 12 | Ti5Al2C3: A New Ternary Carbide Belonging to MAX Phases in the Ti–Al–C System显示文摘 | HuiZhang YonghuiMa YinjieSun | 2012 | J. Am. Ceram. Soc2012，，： | 1 |
| 13 | Providing guaranteed Services without per flow management显示文摘 | Ion Stoica huizhang | 1999 | In proceeding of ACM SIGCOMM1999，，： | 1 |
| 14 | Sonar image seg- mentation based on GMRF and level-set models显示文摘 | Ye Xiufen Zhe Huizhang Liu P X | 2010 | Ocean Engineering2010，37，： | 1 |
| 15 | Safety Culture : an integrative review 显示文摘 | DOUGLAS A WIEGMANN HUIZHANG TERRY L VON THADEN | 2004 | The Internation Journal of Aviation Psychology2004，，2： | 1 |
| 16 | A study on the damping characteristics of laminated composites with integral viscoelastic layers 显示文摘 | Shao Huizhang Hua Lingchen | | Composite Structures0，1，74： | 1 |
| 17 | Nonsynonymous polymorphisms in FAT4 gene are associated with the risk of esophageal cancer in an Eastern Chinese population显示文摘 | Jiangbo Du Jian Ji Yong Gao Lin Xu Jing Xu Chen Zhu Haiyong Gu Jie Jiang Huizhang Li Hongxia Ma Zhibin Hu Guangfu Jin Wei Guo Xiaofei Chen Hongbing Shen | 2013 | Int J Cancer2013，，2： | 1 |
| 18 | Avidin chase reduces side effects of radioimmunotherapy in nude mice bearing human colon carcinoma显示文摘AIM: To evaluate the influence of avidin chase on the side effects of radioimmunotherapy (RIT) in nude mice bearing human colon carcinoma and therapeutic outcome.METHODS: Purified anti-CEA monoclonal antibody (McAb)was biotinylated with NHS-biotin, and then radiolabeled with 188Re by the direct method. 188Re-labeledbiotinylated anti-CEA McAb (188Re-CEA McAb-Bt) was intravenously injected followed by intravenous injection of avidin after 24 h. SPECT imaging and biodistribution study were performed at 28-48 h after the injection of 188Re-CEA McAb-Bt. Three groups of nude mice subcutaneously grafted with human colon carcinoma were treated 7 d after the graft. Mice in the avidin chase group received intravenous injection of 188Re-CEA McAb-Bt (11.1 MBq/20 μg) followed by intravenous injection of cold avidin (80 μg) after 24 h. Mice in the control group (treated group without avidin chase) only received the injection of 188Re-CEA McAb-Bt (11.1 MBq/20 μg), another control group (non-treated group) only received 0.1 mL normal saline solution. Toxicity was evaluated on the basis of change of body weight and peripheral WBC counts, and therapy effects were determined by variation in tumor volume. Histological analysis of tumors was also performed.RESULTS: Avidin chase markedly accelerated the clearance of 188Re-CEA McAb-Bt from the blood and normal tissues. The tumor uptakes of 188Re-CEA Mc Ab-Bt at 28 h were 5.90 and 6.42% ID/g, respectively, in chase group and in non-chase group, while the tumor-to-background (T/NT) ratios were 3.19 and 0.56, respectively. The tumor uptake was slightly decreased by avidin chase, but the T/NT ratios were increased. In treated groups the growth rate of body weight and the number of WBC decreased after injection of 188Re-CEA McAb-Bt, and the WBC counts recovered earlier in the group with avidin chase than in the group without avidin chase. Compared to the nontreated group, treated groups with and without avidin chase showed significant anti-tumor effects.CONCLUSION: Avidin chase can effectively reduce the side effects of RIT, and improve therapeutic efficacy. | Gui-PingLi Yong-XianWang KaiHuang HuiZhang Chun-FuZhang | 2005 | World Journal of Gastroenterology2005，11，13： | 1 |
| 19 | A study on the damping characteristics of laminated 'composites with integral viscoelastic layers 显示文摘 | Shao Huizhang Hua Lingchen | | Composite Structures0，1，74： | 1 |
| 20 | Nonsynonymous polymorphisms in FAT4 gene are associated with the risk of esophageal cancer in an Eastern Chinese population显示文摘 | Jiangbo Du Jian Ji Yong Gao Lin Xu Jing Xu Chen Zhu Haiyong Gu Jie Jiang Huizhang Li Hongxia Ma Zhibin Hu Guangfu Jin Wei Guo Xiaofei Chen Hongbing Shen | 2013 | Cancer2013，，2： | 1 |
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