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| 1 | Systemic: lupus erythemato- sus显示文摘 | D'Cruz DP Khamashta MA Hughes GR | 2007 | Lancet2007，369，9561： | 1 |
| 2 | Hypertension and the antiphospholipid antibodies显示文摘 | Asherson RA Khamashta MA Hughes GR | 1993 | Clin Exp Rheumatol1993，11，5： | 1 |
| 3 | Systemic lupus erythematosus显示文摘 | D'Cruz DP Khamashta MA Hughes GR | 2007 | Lancet2007，369，9561： | 1 |
| 4 | Effects and safety of natriuretic peptides as treatment of cirrhotic ascites:A systematic review and meta-analysis显示文摘BACKGROUND Natriuretic peptides are involved in the cascade of pathophysiological events occurring in liver cirrhosis,counterbalancing vasoconstriction and anti-natriuretic factors.The effects of natriuretic peptides as treatment of cirrhotic ascites have been investigated only in small studies,and definitive results are lacking.AIM To examine the effects and safety of natriuretic peptides in cirrhosis patients with ascites.METHODS We searched MEDLINE,Web of Science,Scopus,Cochrane Library and Embase for all available studies applying intravenous administration of any natriuretic peptide to patients suffering from cirrhotic ascites.Inclusion was not limited by treatment duration or dose,or by follow-up duration.Both randomised controlled trials and non-randomised studies were eligible for inclusion.The primary outcome was change in renal sodium excretion.Secondary outcomes included safety measures and changes in renal water excretion,plasma aldosterone concentration,and plasma renin activity.RESULTS Twenty-two studies were included.Atrial natriuretic peptide(ANP)was the only intensively studied treatment.Sodium excretion increased in response to continuous ANP infusion and was more pronounced when infusion rates of>30 ng/kg/min were administered compared with≤30 ng/kg/min(P<0.01).Moreover,natriuresis was significantly higher in study subgroups with mild/moderate ascites compared with moderate/severe and refractory ascites(P<0.01).ANP infusions increased renal water excretion,although without reaching a statistically significant dose-response gradient.Plasma aldosterone concentration and plasma renin activity were significantly lower at baseline in study subgroups achieving a negative sodium balance in response to an ANP administration compared with treatment non-responders(P<0.01).Blood pressure decreases occurred less frequently when ANP doses≤30 ng/kg/min were applied.The quality of evidence for a natriuretic response to ANP was low,mainly due to small sample sizes and considerable between-study heterogeneity.Data were sparse for the other natriuretic peptides;B-type natriuretic peptide and urodilatin.CONCLUSION Intravenous ANP infusions increase sodium excretion in patients with cirrhotic ascites.Continuous infusion rates>30 ng/kg/min are the most effective.However,safety increases with infusion rates≤30 ng/kg/min. | Rasmus Hvidbjerg Gantzel Mikkel Breinholt Kjær Peter Jepsen Niels Kristian Aagaard Hugh Watson Lise Lotte Gluud Henning Grønbæk | 2022 | World Journal of Hepatology2022，14，4： | 1 |
| 5 | Systemic lupus erythematosus 显示文摘 | D'Cruz DP Khamashta MA Hughes GR | 2007 | Lancet2007，369，： | 1 |
| 6 | Systemic lupus erythematosus显示文摘 | D'Cruz DP Khamashta MA Hughes GR | 2007 | Lancet2007，369，9561： | 1 |
| 7 | ' Overlap' syndromes显示文摘 | Cervera R Khamashta MA Hughes GR | 1990 | Ann Rheum Dis(S0003-4967)1990，49，11： | 1 |
| 8 | Lipoprotein(α) oxidation and autoantibodies: a new path in atherothrombosis 显示文摘 | Romero FI Khamashta MA Hughes GR | 2000 | Lupus2000，9，3： | 1 |
| 9 | Systemic lupus erythematosus显示文摘 | D'cruz DP Khamashta MA Hughes GR | 2007 | Lancet2007，369，9561： | 1 |
| 10 | Systemic lupus erythematosus 显示文摘 | D'Cruz DP Khamashta MA Hughes GR | 2007 | Lancet2007，369，9561： | 1 |
| 11 | The effects of cytokines and growth factors on osteoblastic cells 显示文摘 | Mundy GR Boyce B Hughes D | 1995 | Bone1995，17，2： | 1 |
| 12 | Autoantibodies in the sicca syndrome 显示文摘 | Elkon KB Gharavi AE Hughes GR | 1984 | Ann Rheum Dis1984，43，： | 1 |
| 13 | Systemic lupus erythematous显示文摘 | D'Cruz Dp Khamashta MA Hughes GR | 2007 | Lancet2007，369，9561： | 1 |
| 14 | Lipoprotein (α) oxidation and autoantibodies: a new path in atherothrombosis 显示文摘 | Romero FI Khamashta MA Hughes GR | 2000 | Lupus2000，9，3： | 1 |
| 15 | The effects of cytokines and growth factors on osteoblastie cells显示文摘 | Mundy GR Boyce B Hughes D | 1995 | Bone1995，17，2： | 1 |
| 16 | Intravenous immunoglobulin in the treatment of resistant subacate cutaneous lupus erythematosus: a possible alternative 显示文摘 | Lampropoulos CE Hughes GR D'Cruz DP | 2007 | Clin Rheumatol2007，26，6： | 1 |
| 17 | Thrombosis, abortion, cerebral disease, and lhe lupus an- tieoagulant 显示文摘 | Hughes GR | 1983 | BMJ1983，287，6599： | 1 |
| 18 | , Oxdition of LDL and its clinical implication 显示文摘 | Matsuura E Hughes GR Khamashta MA | 2008 | Autoimmun Rev2008，7，7： | 1 |
| 19 | Systemic lupus erythematosus 显示文摘 | D'CRUZ DP KHAMASHTA MA HUGHES GR | 2007 | Lancet2007，369，： | 1 |
| 20 | The effects of cytokines and growth factors on osteroblastic cells显示文摘 | Mundy GR Boyce B Hughes D | 1995 | Bone1995，17，2： | 1 |
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