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| 1 | Pyogenic liver abscess:An audit of 10 years’experience显示文摘AIM:To describe our own experience with pyogenic liver abscesses over the past 10 years and investigate the risk factors associated with failure of initial percutaneous therapy.METHODS:A retrospective study of records of 63 PLA patients presenting between 1998 and 2008 to Australian tertiary referral centre,were reviewed.Amoebic and hydatid abscesses were excluded.Demographic,clinical,radiological,and microbiological characteristics,as well as surgical/radiological interventions,were recorded.RESULTS:Sixty-three patients(42 males,21 females) aged 65(±14) years[mean±(SD) ]had prodromal symptoms for a median(interquartile range;IQR) of 7(5-14) d.Only 59%of patients were febrile at presentation;however,the serum C-reactive protein was elevated in all 47 in whom it was measured.Liver function tests were non-specifically abnormal.67%of patients had a solitary abscess,while 32%had>3 abscesses with a median(IQR) diameter of 6.3(4-9) cm.Causative organisms were:Streptococcus milleri 25%,Klebsiella pneumoniae 21%,and Escherichia coli 16%.A presumptive cryptogenic cause was most common (34%).Four patients died in this series:one from sepsis,two from advanced cancer,and one from acute myocardial infarction.The initial procedure was radiological aspiration±drainage in 54 and surgery in two patients.17%underwent surgical management during their hospitalization.Serum hypoalbuminaemia[mean (95%CI) :32(29-35) g/L vs 28(25-31) g/L,P=0.045] on presentation was found to be the only factor related to failure of initial percutaneous therapy on univariate analysis.CONCLUSION:PLA is a diagnostic challenge,because the presentation of this condition is non-specific.Intravenous antibiotics and radiological drainage in the first instance allows resolution of most PLAs;However,a small proportion of patients still require surgical drainage. | Tony CY Pang Thomas Fung Jaswinder Samra Thomas J Hugh Ross C Smith | 2011 | World Journal of Gastroenterology2011，17，12： | 46 |
| 2 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 3 | 饮水微量元素与老年人群认知能力关系研究显示文摘在中国山东与河南两省农村研究了饮水中微量元素与老年人群认知能力 (CognitiveFunction)之间的关系。采用中国国标方法分析了饮水中氟、钙、硒、铝、铁、锌、镉、铅、砷微量元素和pH值 ;用老年性痴呆症 (Dementia)调查表 ,进行了≥ 6 5岁老年暴露人群认知能力的测定。调整年龄、性别和文化水平后 ,对微量元素与老年认知能力之间的关系进行直线模型、二次方模型和联合作用模型的统计分析 ,评价饮水中每种微量元素浓度对老年认知能力的影响。结果表明 ,单因素分析时发现几种微量元素对老年认知能力有明显作用。然而 ,在调整其它元素水平后 ,其中一些元素的作用消失。饮水中钙浓度对老年认知能力呈现一作用曲线 ,即随着饮水钙水平升高而认知能力增加 ;到某一点高峰后 ,又随钙水平增加而认知能力降低。而锌与镉之间存在一种相互作用 ,即在低饮水镉水平时 ,锌浓度与认知能力呈正相关 ,但在高饮水镉水平时 。 | 梁超轲 吉荣娣 曹静祥 姜玉亭 余波 马凤 吴云鹏 应波 张妍 孙淑庄 Li Yiming Christine L Emsley Gao Sujuan Kathleen S Hall Hugh C Hendrie | 2003 | 卫生研究2003，32，5： | 12 |
| 4 | Endothelial progenitor cell differentiation using cryopreserved,umbilical cord blood-derived mononuclear cells显示文摘瞄准:调查 umbilicalcord 血(UCB ) 的 endothelial 区别潜力,我们导致了 endothelial 祖先房间(EPC ) 的区别 fromcryopreserved 导出 UCB 的 mononuclear 房间(MNC ).Methods:从 cryopreserved UCB 和 peripheralblood ( PB )的 MNC 在与为由 RT-PCR ,流动 cytometry ,和 immunocytochemistry analysis.The 的 14 d.EPC werecharacterized 的 endothelial 房间生长补充中等的 M199 是有教养的增长 ofdifferentiated EPC 被3-( 4,5-dimethylthiazol-2-yl )学习 -2,5-diphenyl-tetrazolium 溴化物( MTT )试金,并且脉管的 endothelial 生长因素( VEGF )集中用 导出UCB 的 EPC 的 ELISAkit.Characteristics 被测量与 导出PB 的 EPC.Res 的那些相比 numberof 塑造回合的房间泛泛地在 24 h 文化以后被纳入底部,并且 塑造numerousspindle 的房间开始在 d 上从塑造回合的出现了 7 个 .Those 房间 expressedendothelial 标记例如, Flt-l/VEGFR-1 , ecNOS , VE-cadherin , von Willebrand 因素,并且从 PB 和 UCB 的 EPC 的 endothelial 标记的 secretedVEGF.The 模式没证明 VEGF 的增长和分泌物的 strikingdifferences.The 结果也是 similar.Conclusion :与 endothelialcells.Those EPC 的质量在 -196 ° C 存储进房间的 Wesuccessfully 有教养的 UCB 房间能由激活提高 angiogenesis 的邻近的 endothelial cellsand 被用于 angiogenic 治疗学。 | Jun-ho JANG Sun-kyung KIM Jeong-eun CHOI Young-jin KIM Hyun-woo LEE Seok-yun KANG Joon-seong PARK Jin-hyuk CHOI Ho-yeong LIM Hugh C KIM | 2007 | Acta Pharmacologica Sinica2007，28，3： | 11 |
| 5 | Finite element modeling of blood flow in arteries 显示文摘 | Thomas J R Hughes Zarins C K | 1998 | Computer Methods in Applied Mechanics and Engineering1998，158，： | 1 |
| 6 | Neurochemi- cal evaluation of the novel 5-HT1A receptor partial agonist/seroto- nin reuptake inhibitor, vilazodone 显示文摘 | HUGHES ZA STARR KR LANGMEAD C J | 2005 | Eur J Pharmacol2005，510，12： | 1 |
| 7 | Acute and subacute effects of naturally occurring estrogens on luteinizing hormone secretion in the ovariectomised rat: part 2 显示文摘 | Hughes C L Chakinala M M Reece S G | 1991 | Reprod Toxicol1991，5，： | 1 |
| 8 | Fluid capacity distributions of random porous media 显示文摘 | Chan D Y C Hughes B D Paterson L | 1988 | Transport in Porous Media1988，，3： | 1 |
| 9 | Free radicals accelerate the decay of long-term potentiation in field CA1 of guinea-pig hippocampus 显示文摘 | Pellmar T C kaisho Y Hughes P | 1991 | Neurosci1991，44，2： | 1 |
| 10 | Numerical simulation of high strain rate concrete compress test 显示文摘 | Tedesco J W Hughes M L Ross C A | 1994 | Computers & Struc- tures1994，51，1： | 1 |
| 11 | Coordination of anthocyanin decline and photosynthetic maturation in juvenile leaves of three deciduous tree species显示文摘 | Hughes N M Morley C B Smith W K | 2007 | New Phytologist2007，175，： | 1 |
| 12 | The epidemiology of depression in an elderly community population显示文摘 | Blazer D Hughes D C George L K | | 0，，03： | 1 |
| 13 | Flame Extin- guishment Properties of Dry Chemicals: Extinction Concen- trations for Small Diffusion Pan Fires 显示文摘 | EWING C T FAITH F R HUGHES J T | 1989 | Fire Technology1989，，5： | 1 |
| 14 | Biochemical identification of apoptosis(programmed cell death) in granulosa cells: evidence for a potential mechanism underlying follicular atresia显示文摘 | HUGHES F M J R GOROSPE W C | 1991 | Endocrinology1991，129，5： | 1 |
| 15 | Renal artery perfusion modifies ischemia/reperfusion injury显示文摘 | HUGHES J D MATTAR S G CHEN C | 1996 | J Surg Res1996，60，2： | 1 |
| 16 | Ab initio emulsion polymerization by RAFT-controlled self-assembly 显示文摘 | Ferguson C J Hughes R J Nguyen D | 2005 | Macromolecules2005，38，： | 1 |
| 17 | Atrazine:Mechanisms of hormonal imbalance in female SD rats显示文摘 | Chapin R E Stevens J T Hughes C L | 1996 | Funda Appl Toxicol1996，29，： | 1 |
| 18 | Dynamics of an elastic multibody chain:Part D-modelling of joints显示文摘 | Sincarsin G B D'Eleuterio G M T Hughes P C | 1993 | Dynamics and Stability of Systems1993，8，2： | 1 |
| 19 | Finite element analysis of bone stress and strain around a distal osseointegrated implant for prosthetic limb attachment显示文摘 | Xu W Crocombe A D Hughes S C | 2000 | Proc Inst Mech Eng2000，214，6： | 1 |
| 20 | A vision based DSP embedded navigation sensor显示文摘 | Guannam K K Hughes D C Junkins J L | 2002 | IEEE Sensors Journal2002，2，5： | 1 |
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