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| 1 | Alterations of glutathione S-transferase and matrix metalloproteinase-9 expressions are early events in esophageal carcinogenesis显示文摘AIM: To investigate the role of glutathione S-transferase (GST) and matrix metalloproteinase-9 (MMP-9) expres-sions in the development and progression of reflux es-ophagitis-Barrett’s metaplasia-dysplasia-adenocarcinoma sequence in the esophagus.METHODS: GST and MMP-9 expressions were analyzed in 51 paraffin-embedded tissue samples by immunohisto-chemistry including patients with reflux esophagitis (n = 7), Barrett’s metaplasia (n = 14), Barrett and esophagi-tis (n = 8), Barrett and dysplasia (n = 7), esophageal adenocarcinoma (n = 8) and a control group without any histological changes (n = 7). Immunostaining was determined semiquantitatively. Statistical analysis with one-way ANOVA, LSD test and correlation analysis were performed. P value of < 0.05 was considered significant.RESULTS: GST expression was significantly higher while MMP-9 expression was significantly lower in control group compared to Barrett’s metaplasia and the other groups. No major changes were observed between Bar-rett, esophagitis, and Barrett and concomitant esophagi-tis. Barrett and concomitant dysplasia, and adenocarci-noma revealed a significant lower expression of GST and higher levels of MMP-9 compared to all other groups. Adenocarcinoma showed almost no expression of GST and significantly higher levels of MMP-9 than Barrett and concomitant dysplasia. Alterations of GST and MMP-9 were inversely correlated (r = - 0.82).CONCLUSION: Decreased GST and increased ex-pression of MMP-9 in Barrett’s metaplasia-dysplasia-adenocarcinoma sequence as compared to normal tissue suggest their association with esophageal tumorigenesis. Loss of GST and gain of MMP-9 in Barrett with dyspla-sia compared to non-dysplastic metaplasia indicate that these alterations may be early events in carcinogenesis. Quantification of these parameters in Barrett’s esopha-gus might be useful to identify patients at higher risk for progression to cancer. | Laszlo Herszenyi Istvan Hritz Istvan Pregun Ferenc Sipos Mark Juhasz Bela Molnar Zsolt Tulassay | 2007 | World Journal of Gastroenterology2007，13，5： | 37 |
| 2 | Endoscopic transluminal pancreatic necrosectomy using a self-expanding metal stent and high-flow water-jet system显示文摘Walled-off pancreatic necrosis and a pancreatic abscess are the most severe complications of acute pancreatitis. Surgery in such critically ill patients is often associated with significant morbidity and mortality within the first few weeks after the onset of symptoms. Minimal invasive approaches with high success and low mortality rates are therefore of considerable interest. Endoscopic therapy has the potential to offer safe and effective alternative treatment. We report here on 3 consecutive patients with infected walled-off pancreatic necrosis and 1 patient with a pancreatic abscess who underwent direct endoscopic necrosectomy 19-21 d after the onset of acute pancreatitis. The infected pancreatic necrosis or abscess was punctured transluminally with a cystostome and, after balloon dilatation, a non-covered self-expanding biliary metal stent was placed into the necrotic cavity. Following stent deployment, a nasobiliary pigtail catheter was placed into the cavity to ensure continuous irrigation. After 5-7 d, the metal stent was removed endoscopically and the necrotic cavity was entered with a therapeutic gastroscope. Endoscopic debridement was performed via the simultaneous application of a high-flow water-jet system; using a flush knife, a Dormia basket, and hot biopsy forceps. The transluminal endotherapy was repeated 2-5 times daily during the next 10 d. Supportive care included parenteral antibiotics and jejunal feeding. All patients improved dramatically and with resolution of their septic conditions; 3 patients were completely cured without any further complications or the need for surgery. One patient died from a complication of prolonged ventilation severe bilateral pneumonia, not related to the endoscopic procedure. No procedure related complications were observed. Transluminal endoscopic necrosectomy with temporary application of a self-expanding metal stent and a high-flow water-jet system shows promise for enhancing the potential of this endoscopic approach in patients with walled-off pancreatic necrosis and/or a pancreatic abscess. | István Hritz Roland Fejes András Székely Iván Székely László Horváth gnes Sárkány ron Altorjay László Madácsy | 2013 | World Journal of Gastroenterology2013，19，23： | 10 |
| 3 | Long-term omeprazole and esomeprazole treatment does not significantly increase gastric epithelial cell proliferation and epithelial growth factor receptor expression and has no effect on apoptosis and p53 expression显示文摘AIM: To study the effect of proton pump inhibitor (PPI)treatment on patients with reflux esophagitis and its in vivo effect on apoptosis, p53- and epidermal growth factor receptor (EGFR) expression.METHODS: After informed consent was obtained, gastric biopsies of the antrum were taken from patients with reflux oesophagitis prior to and after 6 mo of 20 mg omeprazole (n = 14) or 40 mg esomeprazole (n = 12) therapy.Patients did not take any other medications known to affect the gastric mucosa. All patients were Helicobacter pylori negative as confirmed by rapid urease test and histology,respectively. Cell proliferation, apoptosis, EGFR, and p53expression were measured by immunohistochemical techniques. At least 600 glandular epithelial cells were encountered and results were expressed as percentage of total cells counted. Was considered statistically significant.RESULTS: Although there was a trend towards increase of cell proliferation and EGFR expression both in omeprazole and esomeprazole treated group, the difference was not statistically significant. Neither apoptosis nor p53 expression was affected.CONCLUSION: Long-term PPI treatment does not significantly increase gastric epithelial cell proliferation and EGFR expression and has no effect on apoptosis and p53 expression. | Istvan Hritz Laszlo Herszenyi Bela Molnar Zsolt Tulassay Laszlo Pronai | 2005 | World Journal of Gastroenterology2005，11，30： | 7 |
| 4 | Impact of proteolytic enzymes in colorectal cancer development and progression显示文摘Tumor invasion and metastasis is a highly complicated, multi-step phenomenon. In the complex event of tumor progression, tumor cells interact with basement membrane and extracellular matrix components. Proteolytic enzymes(proteinases) are involved in the degradation of extracellular matrix, but also in cancer invasion and metastasis. The four categories of proteinases(cysteine-, serine-, aspartic-, and metalloproteinases) are named and classified according to the essential catalytic component in their active site. We and others have shown that proteolytic enzymes play a major role not only in colorectal cancer(CRC) invasion and metastasis, but also in malignant transformation of precancerous lesions into cancer. Tissue and serumplasma antigen concentrations of proteinases might be of great value in identifying patients with poor prognosis in CRC. Our results, in concordance with othersindicate the potential tumor marker impact of proteinases for the early diagnosis of CRC. In addition, proteinases may also serve as potential target molecules for therapeutic agents. | László Herszényi Loránd Barabás István Hritz Gábor István Zsolt Tulassay | 2014 | World Journal of Gastroenterology2014，20，37： | 3 |
| 5 | Critical role of Toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury 显示文摘 | Velayudham A Hritz I Dolganiuc A | 2006 | J Hepatol2006，45，6： | 1 |
| 6 | Comparison of the effects of 1,25 dihydroxyvitamin D and 25 hydroxyviamin D on bone pathology and disease activity in Crohn' s disease patients显示文摘 | Miheller P Muzes G Hritz I | | 0，，： | 1 |
| 7 | Critical role of Toll - like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury显示文摘 | Velayudham A Hritz I Dolganiuc A Mandrekar P Kurt - Jones E Sza- bo G | 2006 | Journal of Hep- atology2006，45，： | 1 |
| 8 | The critical role of toll-like receptor(TLR)4 in alcoholic liver disease is independent of the common TLR adapter MyD88显示文摘 | Hritz I Mandrekar P Velayudham A | 2008 | Hepatology2008，48，： | 1 |
| 9 | Hypoxia-induced brain angiogenesis in the adult rat 显示文摘 | Harik SI Hritz MA and LaManna JC | 2011 | J Physiol (Lond)2011，485，2： | 1 |
| 10 | Critical role of Toll- like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury显示文摘 | VELAYUDHAM A HRITZ I DOLGANIUC A | 2006 | J Hepatol2006，45，： | 1 |
| 11 | Matrix Metalloproteinase-9 Expression in the Normal Mucosa–Adenoma–Dysplasia–Adenocarcinoma Sequence of the Colon显示文摘 | László Herszényi Ferenc Sipos Orsolya Galamb Norbert Solymosi István Hritz Pál Miheller Lajos Berczi Béla Molnár Zsolt Tulassay | 2008 | Pathology & Oncology Research2008，，1： | 1 |
| 12 | The critical role of toll-like receptor(TLR)4 in alcoholic liver disease is independent of the com-mon TLR adapter MyD88显示文摘 | Hritz I Mandrekar P Velayudham A | | 0，，： | 1 |
| 13 | Deficiency in myeloid differentiation factor - 2 and Toll - like receptor 4 ex- pression attenuates nonalcoholic steatohepatitis and fibrosis in mice显示文摘 | CSAK T VELAYUDHAM A HRITZ I et el | 2011 | AmJ Physiol Gastrointest Liver Physiol2011，300，3： | 1 |
| 14 | The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88 显示文摘 | Hritz I Mandrekar P Velayudham A | 2008 | Hepatology2008，48，4： | 1 |
| 15 | Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice 显示文摘 | Csak T Velayudham A Hritz I | 2011 | Am J Physiol Gastrointest Liver Physiol2011，300，3： | 1 |
| 16 | Users显示文摘 | Hritz I Herszenyi L Molnar B et aL Proton pump inhibitor co-therapy normalizes the increased cell turnover of the gastric mucosa both in NSAID and selective COX-? | 2005 | Int J Immunopathol Pharmacol2005，18，1： | 1 |
| 17 | Secretory leuko- cyte protease inhibitor expression in various types of gastritis: A specific role of helicobacter pylori infection 显示文摘 | HRITZ I KUESTER D VIETH M | 2006 | Eur J Gast roenterol Hepatol2006，18，3： | 1 |
| 18 | Investigating the sustainability of cruise tourism:A case study of Key West显示文摘 | Hritz N Cecil A K | 2008 | Journal of Sustainable Tourism2008，16，2： | 1 |
| 19 | Contributions of GIS and satellite-based remote sensing to landscape archaeology in the Middle East显示文摘 | Hritz C | 2014 | Journal of Archaeological Research2014，22，3： | 1 |
| 20 | Contributions of GIS and satellite-based remote sensing to landscape archaeology in the middle east显示文摘 | HRITZ C | 2014 | Journal of Archaeological Research2014，22，3： | 1 |
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