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| 1 | Role of polyethylene particles in peri-prosthetic osteolysis:A review显示文摘There is convincing evidence that particles produced by the wear of joint prostheses are causal in the periprosthetic loss of bone,or osteolysis,which,if it progresses,leads to the phenomenon of aseptic loosening.It is important to fully understand the biology of this bone loss because it threatens prosthesis survival,and loosened implants can result in peri-prosthetic fracture,which is disastrous for the patient and presents a difficult surgical scenario.The focus of this review is the bioactivity of polyethylene(PE)particles,since there is evidence that these are major players in the development and progression of osteolysis around prostheses which use PE as the bearing surface.The review describes the biological consequences of interaction of PE particles with macrophages,osteoclasts and cells of the osteoblast lineage,including osteocytes.It explores the possible cellular mechanisms of action of PE and seeks to use the findings to date to propose potential nonsurgical treatments for osteolysis.In particular,a nonsurgical approach is likely to be applicable to implants containing newer,highly cross-linked PEs(HXLPEs),for which osteolysis seems to occur with much reduced PE wear compared with conventional PEs.The caveat here is that we know little as yet about the bioactivity of HXLPE particles and addressing this constitutes our next challenge. | Gerald J Atkins David R Haynes Donald W Howie David M Findlay | 2011 | World Journal of Orthopedics2011，2，10： | 11 |
| 2 | Idempotent Rank in Finite Full Transformation Semigroups显示文摘 | Howie J M McFadden R B | | 0，，： | 1 |
| 3 | Iridescence in plagioclase feldspars显示文摘 | Howie R A | 1998 | The Journal of Gemmology1998，26，1： | 1 |
| 4 | An evaluation of a new two-electrode myocardial electrical impedance monitor for detecting myocardial ischemia 显示文摘 | Howie MB Dzwonczyk R McSweeney TD | 2001 | Anesth Analy2001，92，1： | 1 |
| 5 | Thioredoxin reductase and cytoplasmic glutathione peroxidase activity in human foetal and neonatal liver显示文摘 | Lewin MH Hume R Howie AF | 2001 | Biochim Biophys Acta2001，1526，3： | 1 |
| 6 | Mycoplasma bovis and otitis in dairy calves in the United Kingdom 显示文摘 | Foster A P Naylor R D Howie N M | 2009 | Vet J2009，179，3： | 1 |
| 7 | Large femoral heads decrease the incidence of dislocation after total hip arthroplasty: a randomized controlled trial 显示文摘 | Howie OW Holubowycz OT Middleton R | 2012 | J Bone Joint Surg Am2012，94，12： | 1 |
| 8 | Occurrence of j3-1actamase genes among non-Typhi Sal- monella enterica isolated from humans, food animals, and retail meats in the United States and Canada显示文摘 | SiNund-karlsson M Howie R L BIickenstaff K | 2013 | Microb Drug Resist2013，19，3： | 1 |
| 9 | Idempotent rank in finite full trasformation semigroup显示文摘 | HOWIE J M MCFADDEN R B | 1990 | Proc Roy Soc Edinburgh Sect A1990，114，： | 1 |
| 10 | Pectolite, rock-forming minerals显示文摘 | Deer W A Howie R A Zussman J | 1978 | Single-Chain Silicates1978，，2： | 1 |
| 11 | A new approach to immunological sexing of sperm显示文摘 | BLECHER S R HOWIE R LI S | 1999 | Theriogenology1999，52，8： | 1 |
| 12 | A rat model of resorption of bone at the cement-bone interface in the presence of polyethylene wear particles显示文摘 | Howie DW Vernon-Roberts B Oakeshott R | 1988 | J Bone Joint Surg(Am)1988，70，3： | 1 |
| 13 | Thioredoxin reductase and cytoplasmic glutaione peroxidase activity in human foetal and neonatal liver显示文摘 | Lewin MH Hume R Howie AF | 2001 | Biocheim Biophys Acta2001，1526，3： | 1 |
| 14 | A rat model of resorption of bone at the cement - bone interface in the presence of polyethylene wear particles 显示文摘 | Howie DW Vernon - Roberts B Oakeshott R | 1988 | J Bone Joint Surg Br1988，70，： | 1 |
| 15 | Thioredoxin reductase and Cytoplasmic glutathione peroxidase activity in human foetal and neno- tal liver 显示文摘 | Lewin M H Hume R Howie A F | 2001 | Biochim Biophys Acta2001，1526，： | 1 |
| 16 | Harnessing FOXP3^+ regulatory T cells for transplantation tolerance 显示文摘 | Waldmann H Hilbrands R Howie D | 2014 | J Clin Invest2014，124，4： | 1 |
| 17 | Idenpotent rank in finite full transformation semigroup显示文摘 | Howie J M McFadden R B | | 0，，： | 1 |
| 18 | Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes 显示文摘 | CHO W S DUFFIN R HOWIE S E | 2011 | Part Fibre Toxicol2011，8，1： | 1 |
| 19 | The response to particulate debris显示文摘 | D W Howie D R Hanynes S D Rogers | 1993 | Orthop Clin N Am1993，2，： | 1 |
| 20 | Household concentrations and exposure of children to particulate matter from biomass fuels in the Gambia显示文摘 | Dionisio K L Howie S R C Dominici F | | 0，，06： | 1 |
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