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| 1 | 视神经脊髓炎IgG刺激原代培养大鼠星形胶质细胞免疫反应显示文摘视神经脊髓炎(NMO)主要累及星形胶质细胞,导致中枢神经系统炎症、脱髓鞘和组织损伤。脑内病灶常高表达水通道蛋白4(AQP4),AQP4被认为是NMO血清IgG的抗原目标。根据NMO的可逆性及对NMO病灶演变特点的分析,笔者推测NMO IgG可能诱导了星形胶质细胞的动态免疫过程。培养原代大鼠星形胶质细胞,加入从NMO患者血清中提取或纯化的IgG,星形胶质细胞出现炎性增殖,同时基因表达出现与之匹配的明显变化。且星形胶质细胞反应因子脂质运载蛋白-2、多种趋化因子、细胞因子、应激反应因子的表达均增加。而在培养的原代星形胶质细胞中加入从正常对照者血清中提取的IgG则无上述变化。此星形胶质细胞的反应还与疾病种类相关。从复发缓解型多发硬化、Sj觟gren's或系统性红斑狼疮患者血清中提取的IgG加入培养的原代星形胶质细胞中也不能导致上述变化。笔者推测是NMO IgG与AQP4结合,导致星形胶质细胞出现炎症反应,并出现基因在转录和翻译水平的相应变化。抑制星形胶质细胞的炎症反应可能有助于减少星形胶质细胞增殖,缓解NMO病灶的发展。 | Howe CL Kaptzan T Magaa SM Ayers-Ringler JR LaFrance-Corey RG Lucchinetti CF | 2014 | 神经损伤与功能重建2014，9，3： | 4 |
| 2 | Nerve growth factor signaling, neuroprotection, and neural repair 显示文摘 | Sofroniew MV Howe CL Mobley WC | 2001 | Annu Rev Neurosci2001，24，： | 1 |
| 3 | Nerve growth factor signaling, neuroprotection, and neural repair 显示文摘 | Sofroniew MV Howe CL Mobley WC | 2001 | Ann Rev Neurosci2001，24，： | 1 |
| 4 | Nerve growth factor signaling, neuroprotection, and neural repair显示文摘 | Sofroniew MV Howe CL Mobley WC | 2001 | Annu Rev Neuroscil2001，24，2： | 1 |
| 5 | Antiapoptotic signaling by a remyelination-promoting human antimyelin antibody显示文摘 | Howe CL Bieber AJ Warrington AE | 2004 | Neurobiol Dis2004，15，： | 1 |
| 6 | Growth factor treatment of demyelinating disease:at last, a leap into the light 显示文摘 | Ransohoff RM Howe CL Rodriguez M | 2002 | Trends Immunol2002，23，11： | 1 |
| 7 | Absence ofperforin expression confers axonal protection despite demyelination显示文摘 | Howe CL Adelson JD Rodriguez M | 2007 | Neurobiol Dis2007，25，2： | 1 |
| 8 | Interleukin- 6 protects anterior horn neurons from lethal virus-induced injury显示文摘 | Pavelko KD Howe CL Drescher KM | 2003 | J Neurosci2003，23，2： | 1 |
| 9 | Nerve growth factor signaling,neuroprotection,and neural repair显示文摘 | Sofroniew MV Howe CL Mobley WC | 2001 | Annu Rev Neurosci2001，24，： | 1 |
| 10 | Nerve growth factor and the neurotmphie factor hypotheais显示文摘 | Yuen EC Howe CL Li Y | 1996 | Brain Dev1996，18，5： | 1 |
| 11 | A review of mechanical adjuncts in wound healing: hydrotherapy, ultrasound, negative pressure therapy, hyperbaric oxygen, and electro-stimulation 显示文摘 | Hess CL How ard MA A ttinger CE | 2003 | Ann P last Surg2003，51，2： | 1 |
| 12 | Nerve growth factor signaling, neuroprotection, and neural repair 显示文摘 | HOWE CL MOBLEY WC | 2001 | Ann Rew Neurosci2001，24，： | 1 |
| 13 | Nerve growth factor signaling, neuroprotection, and neural repair显示文摘 | Sofroniew MV Howe CL Mobley WC | 2001 | Annu Rev Neurosci2001，24，： | 1 |
| 14 | Nerve growth factor signaling,neuroprotection,and neural repair显示文摘 | Sofroniew MV Howe CL Mobley WC | | 0，，： | 1 |
| 15 | RhoB controls endothelial cell morphogenesis in part via negative regulation of RhoA显示文摘 | Howe GA Addison CL | | 0，，01： | 1 |
| 16 | Nerve growth factor signaling,neuroprotection and neural repair显示文摘 | Sofroniew MV Howe CL Mobley WC | | 0，，： | 1 |
| 17 | In- flammatory monocytes damage the hippocampus during acute picornavirus infection of the brain显示文摘 | Howe CL Lafrance-Corey RG Sundsbak RS | 2012 | J Neuroin- flammation2012，9，： | 1 |
| 18 | Interleukin-6 protects anterior horn neurons from lethal virus -induced injury显示文摘 | Pavelko KD Howe CL Drescher KM | 2003 | J Neurosci2003，23，2： | 1 |
| 19 | CD8+ T cells directed against a viral peptide contribute to loss of motor function by disrupting axonal transport in a viral model of fulminant demyelination 显示文摘 | Howe CL Ure D Adelson JD | 2007 | J Neuroimmunol2007，188，12： | 1 |
| 20 | Nerve growth factor signa- ling, neuroprotection, and neural repair显示文摘 | Sofroniew MV Howe CL Mobley WC | 2001 | Annu Rev Neurosci2001，24，： | 1 |
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