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| 1 | 视神经脊髓炎IgG刺激原代培养大鼠星形胶质细胞免疫反应显示文摘视神经脊髓炎(NMO)主要累及星形胶质细胞,导致中枢神经系统炎症、脱髓鞘和组织损伤。脑内病灶常高表达水通道蛋白4(AQP4),AQP4被认为是NMO血清IgG的抗原目标。根据NMO的可逆性及对NMO病灶演变特点的分析,笔者推测NMO IgG可能诱导了星形胶质细胞的动态免疫过程。培养原代大鼠星形胶质细胞,加入从NMO患者血清中提取或纯化的IgG,星形胶质细胞出现炎性增殖,同时基因表达出现与之匹配的明显变化。且星形胶质细胞反应因子脂质运载蛋白-2、多种趋化因子、细胞因子、应激反应因子的表达均增加。而在培养的原代星形胶质细胞中加入从正常对照者血清中提取的IgG则无上述变化。此星形胶质细胞的反应还与疾病种类相关。从复发缓解型多发硬化、Sj觟gren's或系统性红斑狼疮患者血清中提取的IgG加入培养的原代星形胶质细胞中也不能导致上述变化。笔者推测是NMO IgG与AQP4结合,导致星形胶质细胞出现炎症反应,并出现基因在转录和翻译水平的相应变化。抑制星形胶质细胞的炎症反应可能有助于减少星形胶质细胞增殖,缓解NMO病灶的发展。 | Howe CL Kaptzan T Magaa SM Ayers-Ringler JR LaFrance-Corey RG Lucchinetti CF | 2014 | 神经损伤与功能重建2014，9，3： | 4 |
| 2 | Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study显示文摘 | Mark S Pearce Jane A Salotti Mark P Little Kieran McHugh Choonsik Lee Kwang Pyo Kim Nicola L Howe Cecile M Ronckers Preetha Rajaraman Alan W Craft Louise Parker Amy Berrington de González | 2012 | The Lancet . 2012 (9840)2012，，： | 3 |
| 3 | 显示文摘 | CLAESSENS S DEMIRGUC-KUNT A HUIZINGA H: How does Foreign Entry Affect the Domestic Banking Market? | 2001 | Journal of Banking and Finance2001，25，： | 1 |
| 4 | Controlled, simultaneous assembly of polyethylenimine onto nanopartiele silica colloids显示文摘 | BRINGLEY J F WLrNDER A HOWE A M | 2006 | Langmuir2006，22，： | 1 |
| 5 | The tale of transforming growth fac- tor-beta (TGFbeta) signaling: a soigne enigma显示文摘 | Chaudhury A Howe PH | 2009 | IUBMB Life2009，61，10： | 1 |
| 6 | Gundersen flaps inthe management of ocular surface disease in an Asian pop- ulation 显示文摘 | LIM L S HOW A C ANG L P | 2009 | Conea2009，28，7： | 1 |
| 7 | Bone marrow trans- plantation (BMT) versus immunosuppression for the treatment of severe aplastic anaemia (SAA): a report of the EBMT SAA working party显示文摘 | Bacigalupo A Hows J Gluckman E | 1988 | Br J Haematol1988，70，2： | 1 |
| 8 | Integrin signaling and eel1 growth control显示文摘 | Howe A Aplin AE Alahari SK | 1998 | Curt Opin Cell Boil1998，10，2： | 1 |
| 9 | A role for cyclooxygenase-2 inhibitors in the prevention and treatment of cancer 显示文摘 | Howe L R Dannenberg A J | 2002 | Semin Oncol2002，29，311： | 1 |
| 10 | Optimal processing of human umbilical cord blood for clinical banking显示文摘 | Denning-Kendall P Donaldson C Nicol A Bradley B Hows J | 1996 | Exp Hematol1996，24，： | 1 |
| 11 | TGFβ1 induces fibronectin synthesis though a c-Jun N-terminal kinase-dependent,Smad4-dependent parthway显示文摘 | HOCEVAR B A BROWN T L HOWE P H | 1999 | EMBO J1999，18，5： | 1 |
| 12 | Molybdenum ZSM-5 zeolite catalysts for the conversion of methane to benzene 显示文摘 | Zhang J Z Longa M A Howe R F | 1998 | Catal Today1998，44，： | 1 |
| 13 | Void growth simulations in single crystals显示文摘 | O'Regan T L Quinn D F Howe M A MeHugh P E | 1997 | Computational Mechanies1997，20，： | 1 |
| 14 | Polypeptide signaling for plant defensive genes exhibits analogies to defense signaling in animals显示文摘 | Daniel R Bergey Gregg A Howe Clarence A Ryan | 1996 | PNAS1996，93，12： | 1 |
| 15 | Studies of potassium ferrite, K1+xFe11O17 显示文摘 | Howe A T Dudley G J | 1976 | J Solid State Chemistry1976，18，： | 1 |
| 16 | Adenoviral-mediated expression of a kinase-dead mutant of Akt induces apoptosis selectively in tumor cells and suppresses tumor growth in mice显示文摘 | Jetzt A Howe JA Horn MT | 2003 | Cancer Res2003，63，20： | 1 |
| 17 | SavvySearch:A MetaSearch Engine That Leams Which Search Engines to Query显示文摘 | Howe A E Dreilinger D | 1997 | AI Magazine1997，18，2： | 1 |
| 18 | Optimal torque control of fault-tolerant permanent magnet brushless machines显示文摘 | WANG Jia-bin KAIS A HOWE D | 2003 | IEEE Transactions on Magnet-ics2003，39，5： | 1 |
| 19 | Swirling flow pattern in a non-planar model of an interposition vein cuff anastomosis 显示文摘 | T V How R K Fisher J A Brennan | 2006 | Med Eng Phys2006，，28： | 1 |
| 20 | Nitrogen transport and transformation in a shallow aquifer receiving wastewater discharge:a mass balance approach显示文摘 | DESIMONE L A HOWES B L | 1998 | Water Resoure Res1998，34，2： | 1 |
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