|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Elucidation of the ‘Honeycrisp’ pedigree through haplotype analysis with a multi-family integrated SNP linkage map and a large apple (Malus×domestica) pedigree-connected SNP data set显示文摘The apple(Malus×domestica)cultivar Honeycrisp has become important economically and as a breeding parent.An earlier study with SSR markers indicated the original recorded pedigree of‘Honeycrisp’was incorrect and‘Keepsake’was identified as one putative parent,the other being unknown.The objective of this study was to verify‘Keepsake’as a parent and identify and genetically describe the unknown parent and its grandparents.A multi-family based dense and high-quality integrated SNP map was created using the apple 8 K Illumina Infinium SNP array.This map was used alongside a large pedigree-connected data set from the RosBREED project to build extended SNP haplotypes and to identify pedigree relationships.‘Keepsake’was verified as one parent of‘Honeycrisp’and‘Duchess of Oldenburg’and‘Golden Delicious’were identified as grandparents through the unknown parent.Following this finding,siblings of‘Honeycrisp’were identified using the SNP data.Breeding records from several of these siblings suggested that the previously unreported parent is a University of Minnesota selection,MN1627.This selection is no longer available,but now is genetically described through imputed SNP haplotypes.We also present the mosaic grandparental composition of‘Honeycrisp’for each of its 17 chromosome pairs.This new pedigree and genetic information will be useful in future pedigree-based genetic studies to connect‘Honeycrisp’with other cultivars used widely in apple breeding programs.The created SNP linkage map will benefit future research using the data from the Illumina apple 8 and 20 K and Affymetrix 480 K SNP arrays. | Nicholas P Howard Eric van de Weg David S Bedford Cameron P Peace Stijn Vanderzande Matthew D Clark Soon Li Teh Lichun Cai James J Luby | 2017 | Horticulture Research2017，4，1： | 9 |
| 2 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 3 | Comparison of thermodilution measured extravascular lung water with chest radiographic assessment of pulmonary oedema in patients with acute lung injury显示文摘 | Brown L M Calfee C S Howard J P | 2013 | Ann Intensive Care2013，3，1： | 1 |
| 4 | Research strategies for safety evaluation of nanomaterials, Part IV : Risk assessment of nanopartlcles显示文摘 | TSUJI J S MAYNARD A D HOWARD C P | 2006 | Toxicological Sciences2006，89，1： | 1 |
| 5 | Analysis of Arithmetic Coding for Data Compression显示文摘 | Howard P G Vitter J S | 2002 | Information Processing and Management2002，28，： | 1 |
| 6 | Relationshipbetween blood pressure and stroke risk in patients with symp-tomatic carotid occlusive disease显示文摘 | Rothwell P M Howard S C Spence J D | 2003 | Stroke2003，34，11： | 1 |
| 7 | Personal health re- cords and hypertension control: a randomized trial显示文摘 | Wagner P J Dias J Howard S | 2012 | J Am Med Inform Assoc2012，19，4： | 1 |
| 8 | Control of friction显示文摘 | Suh N P Mosleh M Howard P S | 1994 | Wear1994，175，1： | 1 |
| 9 | Corporate Governance and Corporate Failure : A survival Analysis显示文摘 | Parker S Gary F P Howard F T | 2008 | Corporate Gover-nance2008，，2： | 1 |
| 10 | Prognostic significance ofvisit-to-visit variability,maximum systolic blood pressure,and episodichypertension显示文摘 | othwell P M Howard S C Dolan E | 2010 | Lancet2010，375，9718： | 1 |
| 11 | Nucleo- tide sequence of the gene for the holeforming toxin aerolysin of Aeromonas hydrophila 显示文摘 | HOWARD S P GARLAND W J GREEN M J | 1987 | Journal of Bacteriology1987，169，6： | 1 |
| 12 | Days and Nights on the Internet the Impact of a Diffusing Technology显示文摘 | Howard P E N Rainie L Jones S | 2001 | American Behavioral Scientist2001，45，3： | 1 |
| 13 | Design, synthesis, and evaluation of a novel sequence-selective epoxidecontaining DNA cross-linking agent based on the pyrrolo benzodiazepine system显示文摘 | Wilson S C Howard P W Forrow S M | 1999 | J Med Chem1999，42，20： | 1 |
| 14 | High-temperature Sealing of Zirconia Ceramics Using Glass-ceramic Bond Materials显示文摘 | Howard P J Pyke S H Wood A | 2000 | Materials Technology2000，15，1： | 1 |
| 15 | Learning and proprietary assets in strategic alliances: Building relational capital 显示文摘 | Prashant K Harbir S Howard P | 2000 | Strategic Management Journal2000，21，3： | 1 |
| 16 | Auditory hallucina- tions inhibit exogenous activation of auditory association cortex 显示文摘 | David A S Woodruff P W Howard R | 1996 | Neuroreport1996，7，4： | 1 |
| 17 | The proline-rich domain of TonB possesses an extended polyproline II-like conformation of sufficient length to span the periplasm of Gram-negative bacteria显示文摘 | Kohler S D Weber A Howard S P | 2010 | Protein Sci2010，19，4： | 1 |
| 18 | Improved method for estimating bioconcentration/bioaccumulation factor from octanol/water partition coefficient显示文摘 | MEYLAN W M HOWARD P H BOETHLING R S | 1999 | Environ Toxicol Chem1999，18，4： | 1 |
| 19 | Correlation performance of chaotic signals in spread spectrum systems显示文摘 | S Rao and S P Howard | 1996 | 7th IEEE Digital Signal Processing Workshop1996，，： | 1 |
| 20 | Analysis of Arithmetic Coding for Data Compression显示文摘 | Howard P G Vitter J S | 1992 | Information Processing and Management:An International Journal1992，28，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员