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| 1 | m^6A mRNA methylation sustains Treg suppressive functions显示文摘 | Jiyu Tong Guangchao Cao Ting Zhang Esen Sefik Maria Carolina Amezcua Vesely James P Broughton Shu Zhu Huabin Li Bin Li Lei Chen Howard Y Chang Bing Su Richard A Flavell Hua-Bing Li | 2018 | Cell Research2018，28，2： | 30 |
| 2 | Elucidation of the ‘Honeycrisp’ pedigree through haplotype analysis with a multi-family integrated SNP linkage map and a large apple (Malus×domestica) pedigree-connected SNP data set显示文摘The apple(Malus×domestica)cultivar Honeycrisp has become important economically and as a breeding parent.An earlier study with SSR markers indicated the original recorded pedigree of‘Honeycrisp’was incorrect and‘Keepsake’was identified as one putative parent,the other being unknown.The objective of this study was to verify‘Keepsake’as a parent and identify and genetically describe the unknown parent and its grandparents.A multi-family based dense and high-quality integrated SNP map was created using the apple 8 K Illumina Infinium SNP array.This map was used alongside a large pedigree-connected data set from the RosBREED project to build extended SNP haplotypes and to identify pedigree relationships.‘Keepsake’was verified as one parent of‘Honeycrisp’and‘Duchess of Oldenburg’and‘Golden Delicious’were identified as grandparents through the unknown parent.Following this finding,siblings of‘Honeycrisp’were identified using the SNP data.Breeding records from several of these siblings suggested that the previously unreported parent is a University of Minnesota selection,MN1627.This selection is no longer available,but now is genetically described through imputed SNP haplotypes.We also present the mosaic grandparental composition of‘Honeycrisp’for each of its 17 chromosome pairs.This new pedigree and genetic information will be useful in future pedigree-based genetic studies to connect‘Honeycrisp’with other cultivars used widely in apple breeding programs.The created SNP linkage map will benefit future research using the data from the Illumina apple 8 and 20 K and Affymetrix 480 K SNP arrays. | Nicholas P Howard Eric van de Weg David S Bedford Cameron P Peace Stijn Vanderzande Matthew D Clark Soon Li Teh Lichun Cai James J Luby | 2017 | Horticulture Research2017，4，1： | 9 |
| 3 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 4 | Improved Technique for the Routine Determination of Tritiated Water in Aqueous Samples显示文摘 | Warwick P E Croudace I W Howard A G | 1999 | Anal Chim Acta1999，382，： | 2 |
| 5 | Clinical features of ischemia in cerebral arterial border zones after periods of reduced cerebral blood flow显示文摘 | Howard R Trend P Russell RWR | 1987 | Arch of Neurol1987，44，： | 1 |
| 6 | Twelve year clinical study of patients with hypoxic cor pulmonale given long term domiciliary therapy显示文摘 | Waterhouse J Howard P | 1987 | Thorax1987，42，1： | 1 |
| 7 | Cost-utility analysis of varenicline versus existing smoking cessation strategies using the BENESCO simulation model:Application to a population of US adult smokers显示文摘 | HOWARD P KNIGHT C BOLER A | 2008 | Pharmaco Economics2008，26，6： | 1 |
| 8 | 显示文摘 | Harber P McCoy JM Howard K | 1991 | Chest1991，100，2： | 1 |
| 9 | Editorial: European Landscape 显示文摘 | Howard P | 2004 | Landscape Research2004，29，4： | 1 |
| 10 | When wildlife tourism goes wrong: acase study of stakeholder and management issues regarding Dingoes on Fraser Island,Australia显示文摘 | Burns G L Howard P | 2003 | Tourism Management2003，，6： | 1 |
| 11 | Efficacy, safety and lack of immunagenicity of insulin aspart compared with regular human insulin for wowen with gestational diabetes mellitus显示文摘 | Pettitt DJ Ospina P Howard C | 2007 | Diabetic Med2007，24，10： | 1 |
| 12 | Modes of action of taurine and granulocyte colony-stimulating factor in neuroprotection显示文摘 | CHANDANA B HOWARD P JANG YEN W | 2012 | Journal of Experimental & Clinical Medicine2012，4，1： | 1 |
| 13 | Are there other persistent organic pollutants? A challenge for environmental chemists显示文摘 | MUIR D C G HOWARD P H | 2006 | Environmental Science & Technology2006，40，23： | 1 |
| 14 | Comparison of thermodilution measured extravascular lung water with chest radiographic assessment of pulmonary oedema in patients with acute lung injury显示文摘 | Brown L M Calfee C S Howard J P | 2013 | Ann Intensive Care2013，3，1： | 1 |
| 15 | Identification of solar sources of major geomagnetic storms between 1996 and 2000显示文摘 | Zhang J Dere K P Howard R A | 2003 | Astrophysical Jouranal2003，582，1： | 1 |
| 16 | Research strategies for safety evaluation of nanomaterials, Part IV : Risk assessment of nanopartlcles显示文摘 | TSUJI J S MAYNARD A D HOWARD C P | 2006 | Toxicological Sciences2006，89，1： | 1 |
| 17 | Progressive biliary pathology associated with common pancreatobiliary channel显示文摘 | Pushparani P Redkar RG Howard ER | 2000 | Pediat Surg2000，35，4： | 1 |
| 18 | Use of organic carbon and loss - on - ignition to estimate soil organic matter in different soil types and horizons显示文摘 | Howard P J A Howard D M | 1990 | Biology and Fertility of soils1990，9，： | 1 |
| 19 | Workshop cluster 1 + γδT- cell receptor T cells for calves express high levels of interfeom - γ,in response to stimulation with interleukin - 12 and intedeukiu - 18 显示文摘 | Price SJ Sopp P Howard CJ | 2007 | Immunology2007，120，1： | 1 |
| 20 | Health and ecological assessment of polynuclear aromatic hydrocarbons显示文摘 | Santodonato J Howard P Basu D | 1981 | J Environ Patbol Toxicol1981，5，1： | 1 |
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