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| 1 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 2 | Direct observation of behaviour of Au nanoclusters on TiO2(110) at elevated temperatures显示文摘 | MITCHELL C E J HOWARD A CARGEN M EGDLL R G | 2001 | Surface Science2001，490，： | 1 |
| 3 | Methanol conversion for the production of hydrogen 显示文摘 | Taylor C E Howard B H Myers C R | 2007 | Industrial & Engineering Chemistry Research2007，，： | 1 |
| 4 | Fault slicing:A new approach to the interpretationof fault detail 显示文摘 | Brown A R Edwards G S Howard R E | 1987 | Geophysics1987，52，10： | 1 |
| 5 | Clubroot of crueiferous crops : New perspectives on an old disease显示文摘 | Howard R J Strelkov S E Harding M W | 2010 | Can J Plant Pathol2010，32，1： | 1 |
| 6 | Extrahepatic biliary atresia: a first-trimester event? Clues from light microscopy and immunohistochemistry显示文摘 | TAN C E DRIVER M HOWARD E R | 1994 | J Pediatr Surg1994，29，6： | 1 |
| 7 | Donepezil for the treatment of agitation in Alzheimer's disease显示文摘 | HOWARD R J JUSZCZAK E BALLARD C G | 2007 | N Engl J Med2007，357，14： | 1 |
| 8 | Novel diterpenoids and hydrocarbons in the Dufour gland of the ectoparasitoid Habrobracon hebetor(Say) (Hymenoptera:Braconidae)显示文摘 | HOWARD R W BAKER J E MORGAN E D | 2003 | Archives of Insect Biochemistry and Physiology2003，54，： | 1 |
| 9 | Cuticular hydrocarbons and wax esters of the ectoparasitoid Habrobracon hebetor:ontogenetic,reproductive,and nutritional effects显示文摘 | HOWARD R W BAKER J E | 2003 | Archives of Insect Biochemistry and Physiology2003，53，： | 1 |
| 10 | Fumonisin B1 carcinoge- nicity in a two-year feeding study using F344 rats and B6C3F1 mice 显示文摘 | Howard P C Eppley R M Stack M E | 2001 | Environmental Health Perspectives2001，109，2： | 1 |
| 11 | Corn as a production system for human and animal vaccines显示文摘 | Streatfield S J Lane J R Brooks C A Barker D K Poage M L Mayor J M Lamphear B J Drees C F Jilka J M Hood E E and Howard J A | 2003 | Vaccine2003，21，： | 1 |
| 12 | Extended Basis 1st-Order CI Study of the 1A', 3A', BIA'', and B 1A', Potential-Energy Sur faces of the O(aP, 1D)q-H2 (lEg+ )Reaction显示文摘 | Howard R E Mclean A D Lester W A | 1979 | J Chem Phys1979，71，： | 1 |
| 13 | Bacterial taxa that limit sulfur flux from the ocean 显示文摘 | Howard E C Henriksen J R Buchan A | 2006 | Science2006，314，5799： | 1 |
| 14 | Conductive polymer composite materials and their utility in electromagnetic shielding applications显示文摘 | Fox R T Wani V Howard K E | 2008 | Journal of Applied Polymer Science2008，107，4： | 1 |
| 15 | Graded-index Pt-AI203 composite solar absorbers显示文摘 | Craighead H G Howard R E Sweeney J E | 1981 | Applied Physics Letters1981，，39： | 1 |
| 16 | Donepezil for the treatment of agitation in Alzheimer's disease显示文摘 | Howard R J Juszczak E Ballard C G | 2007 | N Engl J Med2007，357，： | 1 |
| 17 | Influence diagrams显示文摘 | Howard R A Matheson J E | 2005 | Decision Analysis2005，2，3： | 1 |
| 18 | Solubilization ofminerals by bacteria electrophoretic mobility ofThiobacillus ferrooxidan s in the presence of iron,pyriteand sulfur显示文摘 | Blake II R C Shute E A Howard G T | 1994 | Applied and Environmental Microbiology1994，60，9： | 1 |
| 19 | Metaplastic breast carcinoma with squamous differentiation: molecular and clinical a- nalysis of six cases 显示文摘 | Kochhar R Howard E M Umbreit J N | 2005 | Breast J2005，11，5： | 1 |
| 20 | 应用2017年美国心脏病学会/美国心脏协会血压指南预防潜在的心血管病事件显示文摘该研究在美国高血压成人患者比较血压达到2017年美国心脏病学会/美国心脏协会(American College of Cardiology/American Heart Association,ACC/AHA)指南推荐的血压目标与(1)当前血压水平,(2)达到2003年高血压预防、检测、评估和治疗全国联合委员会(the joint national committee on prevention,detection,evaluatioyl and treatment of highblood pressure,JNC)第七次报告(JNC7)目标;以及(3)达到2014年JNC第8次报告(JNCS)血压目标时可预防的心血管事件数和治疗相关严重不良事件的发生次数。 | Bress AP Colantonio LD Cooper R Kramer H Booth JN Odden MC Bibbins-Domingo K Shimbo D Whelton PK Levitan EB Howard G Bellows BK Kleindorfer D Safford MM Muntner P Andrew E 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 1 |
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