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| 1 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 2 | Improved Technique for the Routine Determination of Tritiated Water in Aqueous Samples显示文摘 | Warwick P E Croudace I W Howard A G | 1999 | Anal Chim Acta1999，382，： | 2 |
| 3 | Direct observation of behaviour of Au nanoclusters on TiO2(110) at elevated temperatures显示文摘 | MITCHELL C E J HOWARD A CARGEN M EGDLL R G | 2001 | Surface Science2001，490，： | 1 |
| 4 | Fault slicing:A new approach to the interpretationof fault detail 显示文摘 | Brown A R Edwards G S Howard R E | 1987 | Geophysics1987，52，10： | 1 |
| 5 | Overproduction of recombinant proteins in plants显示文摘 | EGELKROUT E RAJAN V HOWARD J A | 2012 | Plant Sci2012，184，3： | 1 |
| 6 | Dual Doped High Tg White Organic Light Emitting Devices on Silicon显示文摘 | Ali T A Jones G W Howard W E | 2004 | SID2004，29，： | 1 |
| 7 | Sonolysis promotes indirect Co-C bond cleavage of alkylcob (III) alamin bioconju-gates 显示文摘 | Howard WA Jr Bayomi A Natarajan E | 1997 | Bioconjug Chem1997，8，4： | 1 |
| 8 | DNA sequence required for anaerobic expression of the maize alcohol dehydrogenase1 gene显示文摘 | WALKER J C HOWARD E A DENNIS E S | 1987 | Proc Nat Acad Sci1987，84，19： | 1 |
| 9 | Does type of pancreaticojejunostomy after pancreaticoduodenectomy decrease rate of pancreatic fistula?Arandomized,prospective,dual-institution trial显示文摘 | Berger A C Howard T J Kennedy E P | 2009 | J Am Coil Surg2009，208，5： | 1 |
| 10 | Antithrombotic therapy for atrial fibrillation: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guide- lines显示文摘 | You J J Singer D E Howard P A | 2012 | Chest2012，141，2： | 1 |
| 11 | Product compositions and formation kinetics in rapid pyrolysis of pulverized coal-implications for combustion显示文摘 | SUUBERG E M PETERS W A HOWARD J B | 1980 | Fuels1980，59，6： | 1 |
| 12 | DNA sequences required for anaerobic expression of the maize alcohol dehydrogenas Ⅰ gene显示文摘 | Walker J C Howard E A Freeling M | 1987 | Proc Nat Acad Sci USA1987，84，： | 1 |
| 13 | Adverse reactions to voriconazole显示文摘 | Boyd A E Modi S Howard S J | 2004 | Clin Infect Dis2004，39，15： | 1 |
| 14 | Corn as a production system for human and animal vaccines显示文摘 | Streatfield S J Lane J R Brooks C A Barker D K Poage M L Mayor J M Lamphear B J Drees C F Jilka J M Hood E E and Howard J A | 2003 | Vaccine2003，21，： | 1 |
| 15 | Extended Basis 1st-Order CI Study of the 1A', 3A', BIA'', and B 1A', Potential-Energy Sur faces of the O(aP, 1D)q-H2 (lEg+ )Reaction显示文摘 | Howard R E Mclean A D Lester W A | 1979 | J Chem Phys1979，71，： | 1 |
| 16 | Effect of Stage 0 Sporulation Mutations on Subtilisin Expression显示文摘 | Ferrari E Howard S M H Hoch J A | 1986 | J Bacteriol1986，166，： | 1 |
| 17 | Bacterial taxa that limit sulfur flux from the ocean 显示文摘 | Howard E C Henriksen J R Buchan A | 2006 | Science2006，314，5799： | 1 |
| 18 | Geographical and seasonal distribution of the coconut mite, Aceria guerreronis (Acari: Eriophyidae), in Puerto Rico and Florida, USA显示文摘 | HOWARD F W ABREU-RODRIQUZ E DENMARK H A | 1990 | Journal of Agriculture University of Puerto Rico1990，74，： | 1 |
| 19 | Influence diagrams显示文摘 | Howard R A Matheson J E | 2005 | Decision Analysis2005，2，3： | 1 |
| 20 | Solubilization ofminerals by bacteria electrophoretic mobility ofThiobacillus ferrooxidan s in the presence of iron,pyriteand sulfur显示文摘 | Blake II R C Shute E A Howard G T | 1994 | Applied and Environmental Microbiology1994，60，9： | 1 |
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