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| 1 | Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one- compound peptide libraries显示文摘one-bead-one-compound (OBOC ) 组合的肽图书馆是一个强大的工具识别 ligand 和受体相互作用。这里,我们使用了 OBOC 图书馆技术识别对主要贝壳变应原 tropomyosin 的免疫球蛋白 E (IgE ) epitopes 特定的 mimotopes。有 8-12 氨基酸残余的 OBOC 肽图书馆为 tropomyosin 的 IgE mimotopes 与贝壳过敏症从病人与浆液样品被屏蔽。25 mimotopes 从屏蔽被识别,他们到 tropomyosin 特定的 IgE 的有约束力的反应被肽 ELISA 证实。这些 mimotopes 能基于顺序相同被划分成七簇,并且由聚类的 mimotopes 的 EpiSearch 印射的 epitope 被执行描绘并且证实 mimotopes 的有效性。五从六预言的 epitopes 被发现与 tropomyosin 的以前识别的 epitopes 重叠。为了推进,证实 mimotopes 的模仿潜力, BALB/c 老鼠被使免疫, mimotopes 结合了到锁眼恋栈者 hemocyanin 和 assayed 让他们的能力导致 tropomyosin 特定的抗体。那收到的 mimotope 免疫被发现有 tropomyosin 特定的免疫球蛋白 G 的提高的水平的 BALB/c 老鼠,然而并非收到了无关的 mimotope 的老鼠。这研究用整个 sera 开创 OBOC 图书馆的成功的申请屏蔽并且识别多重虾变应原 mimotopes 并且验证他们在 vitro 使用的模仿潜力,在 vivo,并且在 silico 方法。 | Nicki YH Leung Christine YY Wai Marco HK Ho Ruiwu Liu Kit S Lam Jin Jun Wang Shang An Shu Ka Hou Chu Patrick SC Leung | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 2 | Powder Microstructure and Overlay Coating Property ofNiCrAlY Alloy显示文摘这被显示出更好(20-30 亩 m ) 粉末粒子经历快速的复辉和热抽取到导致微细胞的结构的环境,而更粗糙(40-50 亩 m ) 因为慢冷却跟随的复辉,粉末粒子展出粗糙的细胞、树枝状的混合结构。另外,这也被显示越好粉末粒子尺寸,越 higher 机械性质并且冶金热稳定性过分,涂层由把同样分裂成原子的粉末扔了,它大概为粉末的好尺寸部分被归因于稠密的好谷物结构和氧化物层的形成。(编辑作者摘要) 9 个裁判员。 | Chang, XC Wang, JQ Hao, YY Hou, WL Hu, ZQ | 1998 | Journal of Materials Science & Technology1998，14，4： | 3 |
| 3 | Suppression of postsynaptic density protein 95 expression attenuates increased tyrosine phosphorylation of NR2A subunits of N-methyl-D-aspartate receptors and interactions of Src and Fyn with NR2A after transient brain ischemia in rat hippocampus显示文摘 | Zhang GY Zong YY | 2003 | Neurosci Lett2003，343，2： | 1 |
| 4 | Schwannoma of the gastrointestinal tract : a clinicopathological, immunohistochmnical and ultrastructural study of 33 cases 显示文摘 | Hou YY Tan YS Xu JF | 2006 | Histopathology2006，48，9： | 1 |
| 5 | Evolution and the clinical implica- tion mutations in acute myeloid leukemia-stability during disease DNMT3 A 显示文摘 | Hou HA Kuo YY Liu CY | 2012 | Blood2012，119，2： | 1 |
| 6 | DNMT3A mutations in acute myeloid leukemia:stability during disease evolution and clinical implications显示文摘 | Hou HA Kuo YY Liu CY | 2012 | Blood2012，119，2： | 1 |
| 7 | Clinical implications of the SETBP1 mutation in patients with primary myelodysplastic syndrome and its stability during disease progression 显示文摘 | Hou HA Kuo YY Tang JL | 2014 | Am J Hematnl2014，89，2： | 1 |
| 8 | DNMT3A mutations in acute myeloid leukemia:stability during disease evolution and clinical implications显示文摘 | Hou HA Kuo YY Liu CY | 2012 | Blood2012，119，2： | 1 |
| 9 | Hypoxia specific SDF-1 expression by retinal pigment epithelium initiates bone marrow-derived cells to participate in choroidal neovascularization in a laser-induced mouse model显示文摘 | ZHANG ZX WANG YS SHI YY HOU HY ZHANG C CAI Y | 2011 | Curt Eye Res2011，36，9： | 1 |
| 10 | Trisomy 18 syndrome with incom- plete cantrell syndrome 显示文摘 | Hou YJ Chen FI Ng YY | 2008 | Pediatrics and Neonatology2008，49，3： | 1 |
| 11 | Acute administration of carvedilol is more effective than propranolol plus isosorbide-5-mononitrate in the reduction of portal pressure in patients with viral cirrhosis 显示文摘 | LIN HC YANG YY HOU MC | 2004 | Am J Gastroenterol2004，99，： | 1 |
| 12 | Impact of C-kit and PDGFR-a gene mutations on prognosis of patients with gastrointestinal stromal tumors after complete primary tumor resection 显示文摘 | Hou YY GrabeUus F Weber F | 2009 | J Gastrointest Surg2009，13，： | 1 |
| 13 | Distinct association between aberrant methylation of Wnt inhibitors and genetic alterations in acute myeloid leukaemia显示文摘 | Hou HA Kuo YY Liu CY | 2011 | Br J Cancer2011，105，12： | 1 |
| 14 | Ureaplasma urealyticum infection related to seminal plasma immunosuppressive fac- tors, semen pH and liquefaction duration 显示文摘 | Wang Y Han XD Hou YY | 2005 | Arch Andro2005，51，4： | 1 |
| 15 | Spindle cell carcinoma of the oral cavity and omphatynx: factors affecting outcome 显示文摘 | Su HH Chu ST Hou YY | 2006 | J Chin Meal Assoc2006，69，10： | 1 |
| 16 | Ghrelin protects cortical neu- ron against focal ischemia/reperfusion in rats显示文摘 | Miao YY Xia Q Hou ZC | 2007 | Biochem Biophys Res Commun2007，359，： | 1 |
| 17 | 查看详情显示文摘 | Hou YY PengJ M Chao R B | | 0，，06： | 1 |
| 18 | Effects of steroid hormones on immunoglobulin M (IgM) in rainbow trout,Oncorhynchus mykiss显示文摘 | Hou YY Suzuki Y Aida K | 1999 | Fish Physiol Biochem1999，20，2： | 1 |
| 19 | Hemodynamic effects of a combination of octreotide and terlipressin in patients with viral hepatitis related cirrhosis显示文摘 | Ln HC Yang YY Hou MC | 2002 | Seand J Gastroenterol2002，37，4： | 1 |
| 20 | The clinical implica- tion of SRSF2 mutation in patients with myelodysplas- tic syndrome and its stability during disease evolution 显示文摘 | Wu S J Kuo YY Hou HA | 2012 | Blood2012，120，15： | 1 |
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