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| 1 | Affinity peptide developed by phage display selection for targeting gastric cancer显示文摘AIM:To develop an affinity peptide that binds to gastric cancer used for the detection of early gastric cancer.METHODS:A peptide screen was performed by biopanning the PhD-12 phage display library,clearing non-specific binders against tumor-adjacent normal appearing gastric mucosa and obtaining selective binding against freshly harvested gastric cancer tissues.Tumortargeted binding of selected peptides was confirmed by bound phage counts,enzyme-linked immunosorbent assay,competitive inhibition,fluorescence microscopy and semi-quantitative analysis on immunohistochemistry using different types of cancer tissues.RESULTS:Approximately 92.8% of the non-specific phage clones were subtracted from the original phage library after two rounds of biopanning against normal-appearing gastric mucosa.After the third round of positive screening,the peptide sequence AADNAKTKSFPV(AAD) appeared in 25%(12/48) of the analyzed phages.For the control peptide,these values were 6.8 ± 2.3,5.1 ± 1.7,3.5 ± 2.1,4.6 ± 1.9 and 1.1 ± 0.5,respectively.The values for AAD peptide were statistically signif icant(P < 0.01) for gastric cancer as compared with other histological classif ications and control peptide.CONCLUSION:A novel peptide is discovered to have a specific binding activity to gastric cancer,and can be used to distinguish neoplastic from normal gastric mucosa,demonstrating the potential for early cancer detection on endoscopy. | Wen-Jie Zhang Yan-Xia Sui Arun Budha Jian-Bao Zheng Xue-Jun Sun Ying-Chun Hou Thomas D Wang Shao-Ying Lu | 2012 | World Journal of Gastroenterology2012，18，17： | 12 |
| 2 | Quantum phase transition and entanglement in Li atom system显示文摘By use of the exact diagonalization method, the quantum phase transition and en- tanglement in a 6-Li atom system are studied. It is found that entanglement appears before the quantum phase transition and disappears after it in this exactly solvable quantum system. The present results show that the von Neumann entropy, as a measure of entanglement, may reveal the quantum phase transition in this model. | SI LiMing1 & HOU JiXuan2 1 Department of Electronic Engineering, School of Information Science and Technology, Beijing Institute of Technology, Beijing 100081, China 2 Laboratoire de Chimie, UMR 5182 CNRS, Ecole Normale Supérieure de Lyon, 46, Allée d’Italie, F-69364 Lyon Cedex 07, France | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，11： | 6 |
| 3 | Diaporthe species occurring on citrus in China显示文摘Diaporthe species are important pathogens of a wide range of hosts including many economically important crops.Diaporthe citri is generally accepted to cause melanose of Citrus fruits,leaves and shoots;stem-end rot of fruits and gummosis of perennial branches.In this study,147 strains of Diaporthe were isolated from diseased leaves,twigs,fruits and branches of Citrus from Shaanxi,Zhejiang,Guangxi,Fujian,Guangdong,Jiangxi,Hunan,Chongqing and Shanghai and identified by morphology and molecular analysis of nuclear ribosomal internal transcribed spacer(ITS),partial sequences of translation elongation factor 1-α(EF 1-α),tubulin(TUB)and calmodulin(CAL)genes.All strains from Citrus clustered in three clades.Diaporthe citri was the predominant species and is compared with strains from Florida,USA,where this species was first collected and described.Two new taxa differing from D.citri are described as D.citriasiana and D.citrichinensis in this paper.Inoculation tests indicate that all three species are able to cause stem-end rot of fruits,while only D.citri could cause melanose on leaves. | Feng Huang Xin Hou Megan M Dewdney Yushi Fu Guoqing Chen Kevin D Hyde Hongye Li | 2013 | Fungal Diversity2013，，4： | 4 |
| 4 | Pathotypes and Genetic Diversity of Chinese Collections of Elsinoě fawcettii Causing Citrus Scab显示文摘Two scab diseases are currently recognized on citrus: citrus scab, caused by El sino? fawcettii, and sweet orange scab, caused by E. australis. Although these pathogens are economically important, there is no molecular data on these species in China. Here we use internal transcribed spacer sequence data to report on host-specificity and genetic relationships among 46 isolates collected from the main citrus varieties grown across China. All strains isolated were E. fawcettii. Based on pathogenicity testing on 9 diffe rent citrus species, isolates were divided into 11 path otypes(SM, FBHR, SJCR, SPOJCR, SR, SOJG, SPOJC, SRGC, Lemon and two unnamed pathotypes). SM is a new pathotype, and two isolates did not fit into any of the known pathotypes of E. fawcettii. Inter-simple sequence repeat(ISSR-PCR) assays separated the E. fawcettii isolates into 10 subgroups; the groupings basically corresponded to the pathogenicity test. | HOU Xin HUANG Feng ZHANG Tian-yuan XU Jian-guo Hyde D Kevin LI Hong-ye | 2014 | Journal of Integrative Agriculture2014，13，6： | 4 |
| 5 | Variations in Wool Growth with Nutrient Supply in Northern China显示文摘Field studies on essessment of nutritional status of the grazing sheep were carried out in each of the three major grassland regions, the eastern Inner Mongolia and beyond grassland, the Inner Mongolia - Ningxia - Gansu grassland and the Xinjiang grassland, in northern China. The results obtained showed that the wool production of fine wool sheep in these regions varied between regions and seasons, with similar seasonal patterns in all regions and that reducing the seasonal variations in nutrient supply would enhance wool production substantially. Nutritional limitations to wool growth of the grazing sheep in these regions were suggested, those were: the shortage of protein supply in winter and early spring; the poor quality of much of the pasture and the hay used as supplements, the low energy intake during winter which probably necessitated the use of body stores to maintain body temperature. | D X Lu,Iner(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)Z C Feng,(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)H R Wang,(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)R Z Yang,(Xinjiang Institute of Animal Science.Xinjiang Academy of Animal Science.Yiu Hou Road.Urumqi.Xinjiang Uygur Autonomous Region PRC)C T Ma,(Chinese Academy of Agricultural Sciences.Lanzhou.Gansu.PRC)D B Purser,(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)J R Lindsay(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)D W Peter(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014) | 1997 | 畜牧与饲料科学1997，22，S1： | 3 |
| 6 | Integrated dynamic wet spinning of core-sheath hydrogel fibers for optical-to-brain/tissue communications显示文摘Hydrogel optical light-guides have received substantial interest for applications such as deep-tissue biosensors,optogenetic stimulation and photomedicine due to their biocompatibility,(micro)structure control and tissue-like Young’s modulus.However,despite recent developments,large-scale fabrication with a continuous synthetic methodology,which could produce core-sheath hydrogel fibers with the desired optical and mechanical properties suitable for deep-tissue applications,has yet to be achieved.In this study,we report a versatile concept of integrated light-triggered dynamic wet spinning capable of continuously producing core-sheath hydrogel optical fibers with tunable fiber diameters,and mechanical and optical propagation properties.Furthermore,this concept also exhibited versatility for various kinds of core-sheath functional fibers.The wet spinning synthetic procedure and fabrication process were optimized with the rational design of the core/sheath material interface compatibility[core=poly(ethylene glycol diacrylate-co-acrylamide);sheath=Ca-alginate],optical transparency,refractive index and spinning solution viscosity.The resulting hydrogel optical fibers exhibited desirable low optical attenuation(0.18±0.01 d B cm^(-1) with 650 nm laser light),excellent biocompatibility and tissue-like Young’s modulus(<2.60 MPa).The optical waveguide hydrogel fibers were successfully employed for deep-tissue cancer therapy and brain optogenetic stimulation,confirming that they could serve as an efficient versatile tool for diverse deep-tissue therapy and brain optogenetic applications. | Guoyin Chen Gang Wang Xinrong Tan Kai Hou Qingshuo Meng Peng Zhao Shun Wang Jiayi Zhang Zhan Zhou Tao Chen Yanhua Cheng D Benjamin S.Hsiao Elsa Reichmanis Meifang Zhu | 2021 | National Science Review2021，8，9： | 2 |
| 7 | Resistive Interchange Mode in the Presence of Equilibrium Flow显示文摘 | HOU L PARIS R B WOOD A D | 1996 | Physics of Plasmas American Institute of Physics1996，3，2： | 1 |
| 8 | Improving both bond strength and corrosion resistance of steel rebar in concrete by water immersion or sand blasting of rebar显示文摘 | Hou Jiangyuan Fu Xuli Chung D D L | 1997 | Cement and Concrete Research1997，27，5： | 1 |
| 9 | Tungsten devices in analytical atomic spectrometry显示文摘 | Hou X D Jones B T | 2002 | Spectrochimica Acta Prat B2002，57，6： | 1 |
| 10 | Expression of HIF-lalpha and VEGF in colorectal cancer: association with clinical outcomes and prognostic implieations显示文摘 | Cao D Hou M Guan YS | 2009 | BMC Cancer2009，9，： | 1 |
| 11 | Potential mechanisms of cancer chemoprevention by anthocyanins 显示文摘 | Hou D X | 2003 | Current Molecular Nedicine2003，3，2： | 1 |
| 12 | Preparation of hydrophobic PVDF hollow fiber membranes for desalination through membrane distillation 显示文摘 | Hou D Y Wang J Qu D | 2009 | Water Science and Technology2009，59，6： | 1 |
| 13 | Mechanical characterization of single high-strength electrospun polyimide nanofibres 显示文摘 | CHEN F RENEKERr D H HOU H Q | 2008 | Journal of Physics D: Applied Physics2008，41，2： | 1 |
| 14 | Effects of the molecular structure of the interface and continuous phase on solubilization of water in water/oil microemulsions 显示文摘 | HOU M J SHAH D O | 1987 | Langmuir1987，3，： | 1 |
| 15 | Haplotype frequency distribution and linkage disequilibrium analysis of single nucleotide polymorphisms at the human FMO3 gene locus显示文摘 | Hao DC Sun J Furnes B Schlenk D Hou ZF Zhang YP | 2006 | Biochem Genet2006，44，78： | 1 |
| 16 | Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling显示文摘 | Tang DZ Hou W Zhou Q Zhang M Holz J Sheu TJ Li TF Cheng SD Shi Q Harris SE Chen D Wang YJ | 2010 | J Bone Miner Res2010，25，6： | 1 |
| 17 | Finite-time attitude tracking control for spacecraft using terminal sliding model and chebyshev neural network显示文摘 | ZOU A KUMAR K D HOU Z | | 0，，： | 1 |
| 18 | Interaction between electrical double layers of soil colloids and Fe/Al oxides in suspensions显示文摘 | Hou T Xu R.K Tiwari D Zhao A.Z | | 0，，： | 1 |
| 19 | The Brassica rapa FLC homologue FLC 2is a key regulator of flowering time,identified through transcriptional co-expression networks显示文摘 | Xiao D Zhao J J Hou X L | 2013 | Journal of Experimental Botany2013，64，14： | 1 |
| 20 | Image Signature: High- lighting Sparse Salient Regions 显示文摘 | Hou X D Harel J Koch C | 2012 | IEEE Transac- tions on Pattern Analysis and Machine Intelligence2012，34，19： | 1 |
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