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| 1 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 2 | Anti-TNF antibodies in the treatment of inflammatory intestinal stenoses in Crohn's disease 显示文摘 | HOLTMANN M WANITSCHKE R HELISCH A | 2003 | Z Gastroenterol2003，41，1： | 2 |
| 3 | Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting显示文摘AIM: To investigate the outcome of patients with symptoms of gastroesophageal reflux disease (GERD) referred for endoscopy at 2 and 6 mo post endoscopy. METHODS: Consecutive patients referred for upper endoscopy for assessment of GERD symptoms at two large metropolitan hospitals were invited to participate in a 6-mo non-interventional (observational) study.The two institutions are situated in geographically and socially disparate areas. Data collection was by selfcompletion of questionnaires including the patient assessment of upper gastrointestinal disorders symptoms severity and from hospital records. Endoscopic finding using the Los-Angeles classification, symptom severity and it's clinically relevant improvement as change of at least 25%, therapy and socio-demographic factors were assessed. RESULTS: Baseline data were available for 266 patients and 2-mo and 6-mo follow-up data for 128 and 108 patients respectively. At baseline, 128 patients had erosive and 138 non-erosive reflux disease. Allmost all patient had proton pump inhibitor (PPI) therapy in the past. Overall, patients with non-erosive GERD at the index endoscopy had significantly more severe symptoms as compared to patients with erosive or even complicated GERD while there was no difference with regard to medication. After 2 and 6 mo there was a small, but statistically significant improvement in symptom severity (7.02 ± 5.5 vs 5.9 ± 5.4 and 5.5 ± 5.4 respectively); however, the majority of patients continued to have symptoms (i.e. , after 6 mo 81% with GERD symptoms). Advantaged socioeconomic status as well as being unemployed was associated with greater improvement. CONCLUSION: The majority of GORD patients receive PPI therapy before being referred for endoscopy even though many have symptoms that do not sufficiently respond to PPI therapy. | Nora B Zschau Jane M Andrews Richard H Holloway Mark N Schoeman Kylie Lange William CE Tam Gerald J Holtmann | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 4 | Dissociation of cognitive and emotional empathy in adolescents with autism spectrum disorders显示文摘 | Poustka L Rehm A Holtmann M Bock M Bohmert C Dziobek I | 2010 | Kindheit Und Entwicklung2010，19，： | 1 |
| 5 | Veno-occlusive disease(VOD) in Crohn's disease(CD) treated with azathioprine显示文摘 | HOLTMANN M SCHREINER O KOHLER H | 2003 | Dig Dis Sci2003，48，8： | 1 |
| 6 | Methanol to pro-pylene MTP-Lurgis way显示文摘 | ROTHAEME M HOLTMANN H D | 2002 | Erdol Erdgas Kohle2002，，5： | 1 |
| 7 | Methanol to Propylene MTP:Lurgi’s Way显示文摘 | Rothaemel M Holtmann H D | 2002 | Erdol Erdgas Kohle2002，，5： | 1 |
| 8 | Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis 显示文摘 | Kiesslich R Fritsch J Holtmann M | 2003 | Gastroenterology2003，124，4： | 1 |
| 9 | Hamburg: MTP, methanol to propylene, lurgi's way, creating value from light olefins production and conver- sion显示文摘 | Rothaemel M Holtmann H D | 2001 | 2001，，： | 1 |
| 10 | Anti-TNF antibodies in the treatment of inflammatory intestinal stenoses in Crohn' s disease 显示文摘 | HOLTMANN M WANITSCHKE R HELISCH A | 2003 | Z Gastroenterol2003，41，1： | 1 |
| 11 | Endogenous ciliary neurotrophic factor is a lesion factor for axotomized motoneuron in adult mice 显示文摘 | Sendtner M Gotz g Holtmann 13 | 2007 | J Neurosci2007，17，18： | 1 |
| 12 | Children with benign epiteptiform discharges in the EEG-neurobiological and neuropsychological findings and their clinical relevance显示文摘 | Holtmann M Becket K El Faddagh M | 2004 | Z Kinder Jugendpsyehiatr Psychother2004，32，2： | 1 |
| 13 | Vorholt,Methanol-based industrial biotechnology:current status and future perspectives of methylotrophic bacteria显示文摘 | SCHRADER J SCHILLING M HOLTMANN D | 2009 | Trends in Biotechnology2009，27，2： | 1 |
| 14 | Cardiotrophin-1 is an essential factor in the natural defense of the liver against apoptosis显示文摘 | MARQUES J M BELZE I HOLTMANN B | 2007 | Hepatology2007，45，3： | 1 |
| 15 | Diversity of geometrid moths(Lepidoptera:Geometridae)along an Afrotropical elevational rainforest transect显示文摘 | Axmacher J C G Holtmann L Scheuermann G Brehm K MüllerHohenstein and K Fiedler | | 0，，： | 1 |
| 16 | Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis显示文摘 | Kiesslich R Fritsch J Holtmann M | 2003 | Gastroenterology2003，124，4： | 1 |
| 17 | Functional relevance of soluble TNF-alpha, transmembrane TNF-alpha and TNF signal transduction in gastrointestinal diseases with special reference to inflammatory bowel diseases 显示文摘 | Holtmann MH Schutz M Galle PR | 2002 | Z Gastroenterol2002，40，8： | 1 |
| 18 | Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section显示文摘 | Sendtner M Holtmann B Kolbeck R | 1992 | Nature1992，360，6406： | 1 |
| 19 | 查看详情显示文摘 | Rothaemel M Holtmann H. D | | 0，，： | 1 |
| 20 | Attention deficits and subclinical epileptiform discharges:are EEG diagnostics in ADHD optional or essential显示文摘 | Becker K Sinzig JK Holtmann M | | 0，，6： | 1 |
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