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58篇 您的检索式:作者名="Holtmann B"
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1Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting显示文摘AIM: To investigate the outcome of patients with symptoms of gastroesophageal reflux disease (GERD) referred for endoscopy at 2 and 6 mo post endoscopy. METHODS: Consecutive patients referred for upper endoscopy for assessment of GERD symptoms at two large metropolitan hospitals were invited to participate in a 6-mo non-interventional (observational) study.The two institutions are situated in geographically and socially disparate areas. Data collection was by selfcompletion of questionnaires including the patient assessment of upper gastrointestinal disorders symptoms severity and from hospital records. Endoscopic finding using the Los-Angeles classification, symptom severity and it's clinically relevant improvement as change of at least 25%, therapy and socio-demographic factors were assessed. RESULTS: Baseline data were available for 266 patients and 2-mo and 6-mo follow-up data for 128 and 108 patients respectively. At baseline, 128 patients had erosive and 138 non-erosive reflux disease. Allmost all patient had proton pump inhibitor (PPI) therapy in the past. Overall, patients with non-erosive GERD at the index endoscopy had significantly more severe symptoms as compared to patients with erosive or even complicated GERD while there was no difference with regard to medication. After 2 and 6 mo there was a small, but statistically significant improvement in symptom severity (7.02 ± 5.5 vs 5.9 ± 5.4 and 5.5 ± 5.4 respectively); however, the majority of patients continued to have symptoms (i.e. , after 6 mo 81% with GERD symptoms). Advantaged socioeconomic status as well as being unemployed was associated with greater improvement. CONCLUSION: The majority of GORD patients receive PPI therapy before being referred for endoscopy even though many have symptoms that do not sufficiently respond to PPI therapy.Nora B Zschau Jane M Andrews Richard H Holloway Mark N Schoeman Kylie Lange William CE Tam Gerald J Holtmann 2013World Journal of Gastroenterology2013,19,16:2
2Maintaining remission of ulcerative colitis with the probiotic Eseherichia Coli Nissle 1917 is as effective as with standard mesalazine显示文摘Adam B Liebregts T Holtmann G 2006Z Gas- troenterol2006,44,3:1
3Intrathecal sufentanil (5 vs 10 microg) for labor analgesia:efficacy and side effects显示文摘Norris MC Fogel ST Holtmann B 1998Reg Anesth Pain Med1998,23,3:1
4Cardiotrophin-1 is an essential factor in the natural defense of the liver against apoptosis显示文摘MARQUES J M BELZE I HOLTMANN B 2007Hepatology2007,45,3:1
5Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues 显示文摘Schomhurg L Schweizer U Holtmann B 2003BiochemJ2003,370,2:1
6Disruption of the CNTF gene result in motor neuron degeneration显示文摘Masu Y WolfE Holtmann B 1993Nature1993,365,2:1
7The recognition and management of accidental dural puncture in obstetric patients显示文摘Hunter GJ Fogel ST Holtmann B 1997Anesth Analg1997,84,:1
8Use of ketorolac after lower abdominal surgery:effect on analgesic requirements and surgical outcome显示文摘Parker R K Holtmann B Smith I 1994Anesthesiology1994,80,1:1
9Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section显示文摘Sendtner M Holtmann B Kolbeck R 1992Nature1992,360,6406:1
10Disruption of the CNTF gene results in motor neuron degeneration显示文摘Masu Y Wolf E Holtmann B 1993Nature1993,365,6441:1
11Cardiotrophin-1 is an es- sential factor in the natural defense of the liver against apoptosis显示文摘Marques JM Belze I Holtmann B 2007Hepatology2007,45,3:1
12Ultrastructure and anatomy of nematode-induced syncytia in roots of susceptible and resistant sugar beet显示文摘Holtmann B Kleine M Grundler F M W 2000Protoplasma2000,211,:1
13Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia:a six-week placebo-conrolled,double-blind,multicentre trial显示文摘Holtmann G Adam B Haag S 2003Alim Pharmacol Therap2003,18,1112:1
14A randomized com- parison of four incisions for orbital fraetures显示文摘Holtmann B Wray RC Little AG 1981Plast Reeonstr Surg1981,67,2:1
15Early onset of severe familial amyotrophic lateral sclerosis with a SOD-1 mutation : potental impact of CNTF as a candidate modifier gene显示文摘Gless R Holtmann B Braga M 2002American J human genetics2002,70,5:1
16Effect of supple- mental pre-operative fluid on postoperative nausea and vom- iting显示文摘Ali SZ Taguchi A Holtmann B 2003Anaesthesia2003,58,8:1
17Disruption of the CNTF gene results in motor neuron degeneration显示文摘Masu Y Wolf E Holtmann B 1993Nature1993,365,:1
18Effect of supplemental pre-operative fluid on postoperative nausea and vomiting显示文摘Ali SZ Taguchi A Holtmann B 2003Anaesthesia2003,58,8:1
19Maintaining remission of ulcerative colitis with the probiotic Escherichia Coli Nissle 1917 is as effective as with standard mesalazine 显示文摘Adam B Liebregts T Holtmann G 2006Z Gastroenterol2006,44,:1
20A comparison of three techniques of palatoplasty:early speech result显示文摘Holtmann B Wray RC Weeks PM 1984Ann Plast Surg1984,12,6:1
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