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| 1 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 2 | 基于NMR的代谢组学方法最新进展及应用(英文)显示文摘代谢组学的定义“对病理/生理刺激以及基因改变时生物体系动态的代谢响应进行多参数的定量测量”已被广泛接受.本文对代谢组学研究的最新进展及其在系统生物学中所发挥的作用进行了综述.在代谢组学方法研究方面,着重讨论了现代NMR技术的进展及其对代谢组学所产生的影响,同时也包括用于分离的HPLC及其与质谱的连用技术.对代谢组学广泛应用的概述,主要包括:对正常生理变化的新认识;药物和其他外源性化学物质的副作用;外源性物质对环境污染的影响以及逐渐增多的代谢组学方法在疾病检测中应用. | LINDON J C HOLMES E NICHOLSON J K | 2006 | 波谱学杂志2006，23，1： | 10 |
| 3 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 4 | 心房颤动——当今面临的挑战显示文摘在过去数年里,临床和科撞方面对心房颤动(房颤)的关注明显增加,有关这一论题的出版物数量迅速、稳定的增长就是证明。虽然已有一些新方法治疗遮一心律失常一但大多数房颤患者仍然不得不忍受这一心律失常,包括其不良后果和症状,房颤无疑是虽迫切需要有更好治疗方法的一种心律失常。为了达到这一目的,就需要更深刻地认识房颤的机制.以便开发直接影响这一基础病理生理机制的治疗措施。 | Olsson SB Hansson A Hedin E Holm M Ingemansson M Johansson R Meurling C Pehrson S Roijer A Yuan S 方丕华 | 1997 | 中华心律失常学杂志1997，1，1： | 3 |
| 5 | Aspects of modeling of high voltage ferroelectric nonlinear ceramic capacitors 显示文摘 | CAMPBELL C K VANWYK J D HOLM M F K | 1992 | IEEE Trans Compon Hydirds Manuf Technol1992，15，2： | 2 |
| 6 | Relaxation effects in high-voltage barium titanate non-linear ceramic disk capacitors 显示文摘 | CAMPBELL C K VANWYK J D HOLM M F K | 1993 | IEEE Trans Compon Hydirds Manuf Technol1993，16，4： | 2 |
| 7 | The evolution of epidemic influenza 显示文摘 | Nelson M I Holmes E C | 2007 | Nat Rev Genet2007，8，3： | 1 |
| 8 | Fastand simple Monte Carlo algorithm for side chain optimization in proteins:application to model building by homology显示文摘 | Holm L Sander C | 1992 | Proteins1992，14，2： | 1 |
| 9 | Systemic infections and inflammation affect chronic neurodegeneration显示文摘 | Perry VH Cunningham C Holmes C | 2007 | Nat Rev Immunol2007，7，： | 1 |
| 10 | Science review: vasopressin and the cardiovascular system part 2-clinical physiology显示文摘 | HOLMES C L | 2004 | Crit Care2004，8，： | 1 |
| 11 | Guidelines for prevention and treatment of opportunistic infections in HIV - infected adults and adolescents显示文摘 | Kaplan JE Benson C Holmes KH | 2009 | MMWR Recomm Rep2009，58，4： | 1 |
| 12 | 显示文摘 | Grudowski P A Holmes A L Eiting C | 1996 | Appl Phys Lett1996，69，： | 1 |
| 13 | Genomic diversity evolutionof the lyssaviruses显示文摘 | Delmas O Holmes EC Talbi C | 2008 | PLoS ONE2008，3，4： | 1 |
| 14 | A review of recent progress towards development of a formulated microbound diet for mud crab, Scylla serrata, larvae and their nutritional requirements显示文摘 | HOLME M H ZENG C S SOUTHGATE P C | 2009 | Aquaculture2009，286，： | 1 |
| 15 | Some simple modules for the restricted Cartan-type Lie algebras 显示文摘 | Holmes R R Zhang C W | 2002 | J Pure Appl Algebra2002，173，13： | 1 |
| 16 | Use of surfactant to reduce CO2 mobility in oil displacement 显示文摘 | Bernard G C Holm L W Harvey C P | 1980 | Soc Pet Engrs J1980，20，4： | 1 |
| 17 | Toxicological applications of magnetic resonance显示文摘 | LINDON J C HOLMES E NICHOLSON J K | | 0，，： | 1 |
| 18 | Molecular mechanisms regulating hormone-sensi- tive lipase and lipolysis 显示文摘 | Holm C | 2003 | Biochem Soc Trans2003，31，6： | 1 |
| 19 | Photon-number-state preparation in nondegenerate parametric amplification显示文摘 | Holmes C A Milburn G J Walls D F | 1989 | Phys Rev A1989，39，5： | 1 |
| 20 | Propranolol as first-line treat- ment for rapidly proliferating infantile hemangiomas显示文摘 | Holmes WJ Mishra A Gorst C | 2011 | J Hast Re- constr Aesthet Surg2011，64，： | 1 |
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