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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 3 | Methods, units and quality requirements for the analysis of haemoglobin A_(1c) in diabetes mellitus显示文摘The formation of glycohemoglobin, especially the hemoglobin A1c(Hb_(A1c)) fraction, occurs when glucose becomes coupled with the amino acid valine in the β-chain of Hb; this reaction is dependent on the plasma concentration of glucose. Since the early 1970 s it has been known that diabetics display higher values of Hb_(A1c) because they have elevated blood glucose concentrations. Thus Hb_(A1c) has acquired a very important role in the treatment and diagnosis of diabetes mellitus. After the introduction of the first quantitative measurement of Hb_(A1c), numerous methods for glycohemoglobin have been introduced with different assay principles: From a simple minicolumn technique to the very accurate automated highpressure chromatography and lastly to many automated immunochemical or enzymatic assays. In early days, the results of the quality control reports for Hb_(A1c) varied extensively between laboratories, therefore in United States and Canada working groups(WG) of the Diabetes Controls and Complications Trial(DCCT) were set up to standardize the Hb_(A1c) assays against the DCCT/National Glycohemoglobin Standardization Program reference method based on liquid chromatography. In the 1990 s, the International Federation of Clinical Chemistry and Laboratory Medicine(IFCC) appointed a new WG to plan a reference preparation and method for the Hb_(A1c) measurement. When the reference procedureswere established, in 2004 IFCC recommended that all manufacturers for equipment used in Hb_(A1c) assays should calibrate their methods to their proposals. This led to an improvement in the coefficient of variation(CV%) associated with the assay. In this review, we describe the glycation of Hb, methods, standardization of the Hb_(A1c) assays, analytical problems, problems with the units in which Hb_(A1c) values are expressed, reference values, quality control aspects, target requirements for Hb_(A1c), and the relationship of the plasma glucose values to Hb_(A1c) concentrations. We also note that the acceptance of the mmol/mol system for Hb_(A1c) as recommended by IFCC, i.e., the new unit and reference ranges, are becoming only slowly accepted outside of Europe where it seems that expressing Hb_(A1c) values either only in per cent units or with parallel reporting of percent and mmol/mol will continue. We believe that these issues should be resolved in the future and that it would avoid confusion if mmol/mol unit for Hb_(A1c) were to gain worldwide acceptance. | Ilkka Penttil? Karri Penttil? P?ivi Holm Harri Laitinen P?ivi Ranta Jukka T?rr?nen Rainer Rauramaa | 2016 | World Journal of Methodology2016，6，2： | 3 |
| 4 | Multicarrier PWM strategies for multilevel inverters 显示文摘 | McGrath B P Holmes D G | 2002 | Industrial Electronics IEEE Transactions2002，49，4： | 2 |
| 5 | Aplication of the zona-free manipulation technique to porcine somatic cell nuclear transfer 显示文摘 | P J Booth S J Tan P Holm | 2001 | Cloning and Stem Cells2001，3，4： | 2 |
| 6 | Overall efficiency of in vitro embryo production and vitrification in cattle显示文摘 | G Vajta P Holm T Greve | 1996 | Theriogenology1996，45，： | 2 |
| 7 | New method for culture of zona-included or zona-free embryos: The well of the well (WOW) system显示文摘 | G Vajta T T Peura P Holm | 2000 | Molecular Reproduction andDevelopment2000，55，： | 2 |
| 8 | Heave plate design with computational fluid dynamics 显示文摘 | Holmes S Bhat S Beynet P | 2001 | Journal of Offshore Mechanics and Artic Engineering2001，123，1： | 1 |
| 9 | Growing scalefree networks with tunable clustering显示文摘 | HOLME P KIM B J | 2002 | Physical Review E2002，65，02： | 1 |
| 10 | Chronic fatigue syndrome; H working case definition 显示文摘 | Holmes G P Kaplan J E Gantz N M | 1988 | Ann InternMed1988，108，： | 1 |
| 11 | Hyppothalamic arousel,insulin resistance and Type 2 dibetes millitus显示文摘 | Bjorntorp P Holm G Rosmond R | 1999 | Diabe Med1999，16，5： | 1 |
| 12 | 显示文摘 | Grudowski P A Holmes A L Eiting C | 1996 | Appl Phys Lett1996，69，： | 1 |
| 13 | Global existence theory for a generalized Ginzburg-Landau equation显示文摘 | DUAN J HOLMES P TITI E S | 1992 | Nonlinearity1992，，5： | 1 |
| 14 | A periodically forced Impact oscillator with large dissipation显示文摘 | Shaw S W Holmes P J | 1983 | Journal of Applied Mechanics1983，50，： | 1 |
| 15 | Vitrification of porcine embryos using the Open Pulled Straw(OPS) method 显示文摘 | Vajta G Holm P Greve T | 1997 | Acta Vet Scand1997，38，4： | 1 |
| 16 | A review of recent progress towards development of a formulated microbound diet for mud crab, Scylla serrata, larvae and their nutritional requirements显示文摘 | HOLME M H ZENG C S SOUTHGATE P C | 2009 | Aquaculture2009，286，： | 1 |
| 17 | Vertex overload breakdown in evolving networks显示文摘 | Holme P Kim B J | 2002 | Physical Review E2002，65，06： | 1 |
| 18 | Attack Vulnerability of Complex Networks 显示文摘 | Holme P Kim B J | 2002 | Physical Review E (S 1063-651X)2002，65，05： | 1 |
| 19 | The E75 HER2/neu peptide vaccine 显示文摘 | Mittendorf E A Holmes J P Ponniah S | 2008 | Cancer Immunol lmmu- nother2008，57，10： | 1 |
| 20 | Use of surfactant to reduce CO2 mobility in oil displacement 显示文摘 | Bernard G C Holm L W Harvey C P | 1980 | Soc Pet Engrs J1980，20，4： | 1 |
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