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您的检索式：作者名="HOFSTETTER Heike"
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| 1 | Antibodies as Tailor-Made Chiral Selectors: an Interdisciplinary Approach to Enantiomer Separation and Detection显示文摘It has long been known that the configurational isomers of biologically active compounds, e.g., nutrients, pesticides, and drugs, may exhibit different activities in a chiral environment such as the human body. Although the majority of drugs presently in development are chiral, analytical and preparative methods for the quantitative determination and purification of stereoisomers still lag behind. One reason is that commonly used chiral selectors for the direct resolution of enantiomers are not tailor-made for a specific analyte. The identification of suitable selectors for a particular pair of enantiomers still requires considerable experimentation and is generally demanding with regard to material, time and labor. The rational design of chiral host molecules, therefore, represents a challenge in facilitating enantiomer analysis. In this article, we describe how a combination of techniques ranging from organic synthesis to molecular biology yields antibodies of predetermined specificity and stereoselectivity that can be used as tailor-made chiral selectors for the chromatographic separation of enantiomers and their sensitive detection in immunosensors. | HOFSTETTER Heike HOFSTETTER Oliver | 2005 | 色谱2005，23，5： | 3 |
| 2 | Antibodies as tailor-made chiral selectors for detection and separation of stereoisomers显示文摘 | Heike Hofstetter Oliver Hofstetter | 2005 | Trends in Analytical Chemistry2005，，10： | 1 |
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