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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | Ripening and quality responses of avocado,custard apple,mango and papaya fruit to 1-methylcyclopropene显示文摘 | Hofman P J Jobin-Décor M Meiburg G F | 2001 | Australian Journal of Experimental Agriculture2001，41，4： | 1 |
| 3 | Ripening and quality responses of avocado, custardapple, mango and papaya fruit tol-MCP显示文摘 | Hofman P J Jobin D M Meiburg G F | 2001 | Australian Journal of Experiment Agriculture2001，41，： | 1 |
| 4 | Low temperature conditioning before cold disinfestation improves 'Hass' avocado fruit quality显示文摘 | Hofman P J Stubbings B A Adkins M F | 2003 | Postharvest Biology and Technology2003，28，1： | 1 |
| 5 | Circulating antibody against tumor necrosis factor-alpha protects rat brain from reperfusion injury 显示文摘 | LAVINE S D HOFMAN F M ZLOKOVIC B V | 1998 | J Cereb Blood Flow Matab1998，18，1： | 1 |
| 6 | GDF5 single nucleotide polymorr phism rs143383 is associated with lumbar disc degeneration inNorthern European women显示文摘 | Williams F M Popham M Hart D J de Schepper E Bierma Zeinstra S Hofman A | 2011 | Arthritis Rheum2011，63，： | 1 |
| 7 | Absence of a prominent Th2 cytokine response in human tuberculosis显示文摘 | Lin Y Zhang M Hofman F M | 1996 | Infect Immun1996，64，6： | 1 |
| 8 | Cell cycle phase-specific survival of CD95 ligand-challenged Jurkat cells:upregulation of heatshock response显示文摘 | Parr T B Hofman F M Kiener P A | 2001 | Cell Immunol2001，211，： | 1 |
| 9 | Sensitive salivary estradiol for monitoring ovarian function显示文摘 | WORTHMAN C M STALLINGS J F HOFMAN L F | | 0，，： | 1 |
| 10 | Circulating antibody against tumor necrosis factor- alpha protects rat brain from reperfusion injury 显示文摘 | Lavine S D Hofman F M Zlokovic B V | 1998 | J Cereb Blood Flow Metab1998，18，： | 1 |
| 11 | The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis显示文摘 | Bost F Aouadi M Caron L Even P Belmonte N Prot M Dani C Hofman P Pagès G P | | 0，，02： | 1 |
| 12 | Recovery of primary transformants of soybean显示文摘 | Parrott W A Hofman L M Hildebrand D F | 1989 | Plant Cell Reports1989，7，： | 1 |
| 13 | Manipula-ting avocado fruit ripening with 1-methylcyclopropene显示文摘 | Adkins M F Hofman P J Stubbings B A | 2005 | Postharvest Biol Technol2005，35，： | 1 |
| 14 | Annual variations in the vaso- pressin neuron population of the human suprachiasmatic nucleus显示文摘 | Hofman M A Purba J S Swaab D F | 1999 | Neuroscience1999，53，4： | 1 |
| 15 | Alterations in the hypothalamic paraventricular nucleus and its oxytocin neurons (putative satiety cells) in Prader-Willi syndrome:a study of five cases显示文摘 | Swaab D F Purba J S Hofman M A | 1995 | J Clin Endocrinol Metab1995，80，： | 1 |
| 16 | A simple method for isolation and characterization of mouse brain microvascular endothelial cells显示文摘 | Wu Z Hofman F M Zlokovic B V | 2003 | J Neurosei Methods2003，130，1： | 1 |
| 17 | Circulating antibody against tumor necro sis factor-alpha protects rat brain from reperfusion injury 显示文摘 | Lavine S D Hofman F M Zlokovic B V | 1998 | J Cereb Blood Flow Metab1998，18，1： | 1 |
| 18 | Ripening and quality responses of avocado, custard apple, mango and papaya fruit to 1-rnethylcyclopropene显示文摘 | HOFMAN P J JOBIN-D COR M MEIBURG G F | 2001 | Australian Journal of Experimental Agriculture2001，41，4： | 1 |
| 19 | Retinal vessel diameters and risk of stroke: The Rotterdam Study显示文摘 | M K. Ikram F J. de Jong M J. Bos J R. Vingerling A Hofman P J. Koudstaal P T.V.M. de Jong M M.B. Breteler | 2006 | Neurology2006，，9： | 1 |
| 20 | Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript显示文摘 | Perng G C Jones C Ciacci-Zanella J Stone M Henderson G Yukht A Slanina S M Hofman F M Ghiasi H Nesburn A B Wechsler S L | 2000 | Science2000，287，： | 1 |
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