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| 1 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 2 | Oxidation behavior of diamond-like carbon films 显示文摘 | Wang D Y Chang C L Ho W Y | 1999 | Surface and Coatings Technology1999，120，： | 2 |
| 3 | CD95 (Fas)-dependen elimination of self-reactive B cells upon interaction with CD4+T cells 显示文摘 | Rathmell JC Cooke M P Ho W Y et aI | 1995 | Nature1995，376，6536： | 1 |
| 4 | Outcome analysis of intraventricular thrombolytic therapy for intraventricular haemorrhage 显示文摘 | LEE M W PANG K Y HO W W | 2003 | Hong Kong Med J2003，9，5： | 1 |
| 5 | Field - amplified sample stacking in capillary electrophoresis for the determination of clozapine, clozapine N - oxide, anddesmethylclozapine in schizophrenics' plasma显示文摘 | Ho Y H Ko W K Kou W S | 2004 | Journal of Chromatography B2004，809，： | 1 |
| 6 | Probiotics in poultry:Modes of action Worlds Poult显示文摘 | Jin L Z Ho Y W Abdullah N | 1997 | Sci J1997，53，： | 1 |
| 7 | Coherent Optical OFDM Transmitter Design Employing Predistortion 显示文摘 | TANG Y HO K P SHIEH W | 2008 | 1EEE Photonics Technology Letters2008，20，11： | 1 |
| 8 | The relative contribution of Chkl and Chk2 to Adriamycin induced checkpoint 显示文摘 | HO C C SIU W Y CHOW J P | 2005 | Exp Cell Res2005，304，1： | 1 |
| 9 | Basic fibroblast growth factor delivery enhances adrenal cortical cellular regeneration显示文摘 | CHU Y HO W J DUNN JC | 2009 | Tissue Eng Part A2009，15，8： | 1 |
| 10 | Molecular characterization of fluoroquinolone resistance in Mycobacterium tuberculosis: functional analysis of gyrA mutation at position 74 显示文摘 | Lau R W Ho P L Kao R Y | 2011 | Antimicrob Agents Chemother2011，55，2： | 1 |
| 11 | Characterization of tea catechins-loaded nanoparticles prepared from chitosan and an edible polypeptide显示文摘 | Tang D W Yu S H Ho Y C | | 0，，01： | 1 |
| 12 | 17-Beta Estradiol and Hydroxyestradiols Interact via the NFKappaB Pathway to Elevate Cyclooxygenase 2 Expression and Prostaglandin E2 Secretion in Human Bronchial Epithelial Cells显示文摘 | Ho C C Ling Y C Chang L W | | 0，，02： | 1 |
| 13 | Colorectal neoplasia in Asia: a multicenter colonscopy survey in symptomatic patients显示文摘 | LEUNG W K HO K Y KIM W H | 2006 | Gastrointest Endosc2006，64，： | 1 |
| 14 | Relationships between explanatory style, posttraumatic growth and posttraumatic stress disorder symptoms among Chinese breast cancer patients显示文摘 | Ho S M Y Chart M W Y Yau T K | 2011 | Psychology and Health2011，，3： | 1 |
| 15 | Successful design and development of genetically engineered Saccharomyces yeasts for effective cofermentation of glucose and xylose from cellulosic biomass to fuel ethanol显示文摘 | Ho N W Y Chen Z Brainard A P | 1999 | Adv Biochem Engn Biotech1999，65，： | 1 |
| 16 | Psychometric properties of the Chinese version of the mini-mental adjustment to cancer (MINI-MAC) scale显示文摘 | Ho S M Y Kam Fung W Chan C L W | 2003 | Psycho Oncol2003，12，6： | 1 |
| 17 | Reduced expression of APC and DCC gene protein in breast cancer显示文摘 | Ho K Y Kalle W H Lo T H | 1999 | Histopathology1999，35，3： | 1 |
| 18 | OPSO:Orthogonal particle swarm optimization and its application to task assignment problems显示文摘 | Ho S Y Lin H S Liauh W H | 2008 | IEEE Transactions on Systems Man and Cybernetics Part A: System and Humans2008，38，2： | 1 |
| 19 | Overexpression of cellular glutathione peroxidase does not affect expres- sion of plasma glutathione peroxidase or phospholipid hydroperoxide glutathione peroxidase in mice offered diets adequate or deficient in selenium显示文摘 | Cheng W H Ho Y S Ross DA | 1997 | The Journal of nutrition1997，127，5： | 1 |
| 20 | Regression analysis for the sorption isotherms of basic dyes on sugarcane dust显示文摘 | Ho Y S Chiu W T Wang C C | 2005 | Bioresour Techonl2005，96，： | 1 |
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