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	题名	作者	年代	出处	被引量
1	Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters.	V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun	2003	World Journal of Gastroenterology2003，9，10：	5
2	Engineering hybrid genes without the use of restriction enzymesgene splicing by overlap extension显示文摘	HORTON R M HUNT H D HO S N	1989	Gene1989，77，1：	1
3	Site directed mutagenesis by over lap extension using the polymerase chain reaction 显示文摘	Ho S N Hunt H D Horton R N	1989	Gene1989，77，：	1
4	Antibacterial activity of chitosans and chitosan oligomers with different molecular weights显示文摘	No H K Young Park N Ho Lee S Meyers S P	2002	International Journal of Food Microbiology2002，74，12：	1
5	Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘	Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C	2009	Nature2009，458，7238：	1
6	Unsteady aerodynamics and flow control for flapping wing flyers显示文摘	Ho S Nassef H Pornsinsirirak N		0，，8：	1
7	Clinical and radiological comparison of posterolateral fusion and posterior interbody fusion techniques for multilevel lumbar spinal stabilization in manual workers显示文摘	Aygu n H Cakar A HO seyino?lu N	2014	Asian Spine J2014，8，5：	1
8	Site-directed mutgenesis by overlap extension using, the polymerase chain reaction 显示文摘	Ho S N Hunt H D Horton R M	1989	Gene1989，，77：	1
9	Screening of anabolic steroids in horse urine by liquid chromatography-tandem mass spectrometry显示文摘	Yu N H Ho E N M Leung D K K	2005	J Pharm Biomed Anal2005，37，：	1
10	Effect of magnetite nanoparticle agglomerates on ultrasound induced inertial cavitation显示文摘	Smith M J Ho V H B Darton N J		0，，06：	1
11	Implications of nursing care in the occurrence and consequences of unplanned extubation in adult intensive care units显示文摘	Yeh S H Lee L N Ho T H		0，，03：	1
12	Protective effects of aucubinisolated from Eucommia ulmoides against UVB - induced oxida-tive stress in human skin fibroblasts 显示文摘	Ho J N Lee Y H Park J S	2005	Biol Pharm Bull2005，28，：	1
13	Engineering hy- brigenes without the use of restriction enzymes: gene splicing by overlap extension 显示文摘	Horton R M Hunt H D Ho S N	1989	Gene1989，，77：	1
14	Site-directed Mutagenesis by Overlap Extension Using the Polymerase Chain Reaction 显示文摘	HO S N HUNT H D HORTON R M	1989	Gene1989，77，1：	1
15	Reaction of ferrocene with polyaromatic molecules arene: bis ( cyclopentadienyl iron dications) molecular structure 显示文摘	Ho E Y Hendrickson D N	1974	J Am Chem Soc1974，96，：	1
16	Thromibin inhibition attenuates neurodegeneration and cerebral edema formation following transient forebrain ischemia显示文摘	Ohyama H Ho somi N Takahashi T	2001	Brain Res2001，902，2：	1
17	Reaction of ferrocene with polyaromatic molecules arene: bis (cyclopentadienyl iron dications) electronic structure显示文摘	Ho E Y Hendrickson D N	1975	Inorg Chem1975，14，：	1
18	Modeling the Psychology of Consumer and Firm Behavior Using Behavioral Economics 显示文摘	HO T H LIM N CAMERER C F	2006	Journal of Market Research2006，43，8：	1
19	Induction and emergence behav- ior of children undergoing general anesthesia correlates with mater- nal salivary amylase activity before the anesthesia 显示文摘	Arai YC Kandatsu N ho H	2008	Acta Anaes- thesiol Scand2008，52，12：	1
20	An apparently new enterovirus isolated from patients with disease of the central nervous system显示文摘	Schmidt N Lennette E Ho H		0，，：	1

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