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| 1 | Intraoperative radiofrequency ablation with or without tumorectomy for hepatocellular carcinoma in locations difficult for a percutaneous approach显示文摘BACKGROUND:Although hepatic resection is widely accepted as a proper modality for treating hepatocellular carcinoma(HCC),a majority of patients are unable to undergo surgical resection due to various tumor and patient factors.Radiofrequency ablation(RFA)has mostly been used as a therapeutic alternative to resection for treating HCC.The objective of this study was to evaluate the results of intraoperative RFA for HCCs in locations difficult for a percutaneous approach.METHODS:Eight patients(male,seven;age,49-67 years) with 8 HCCs in difficult locations were treated by intraoperative RFA.Six of the patients had local tumor progression after initial transarterial chemoembolization or ultrasound(US)guided percutaneous RFA.The locations of the tumors were hepatic dome in six patients,posterior subcapsule in one,and caudate lobe in one.The tumor size was 2.0 to 6.4 cm(mean,3.9 cm).Intraoperative RFA was performed at the tumor itself and an anticipated resection line under US guidance with 3 cm monopolar single or clustered internally cooled electrodes.Tumor resection was performed in six patients.One month later,treatment response was assessed by contrast material-enhanced computed tomography(CT).CT studies were performed every 2 or 3 months after RFA.RESULTS:RFA was technically successful in all tumors,and the contrast-enhanced CT images acquired one month later showed complete disappearance of tumor enhancement.One pneumothorax occurred.After a median follow-up of 18 months(range,6-30 months),no tumors showed local progression.During the follow-up period,four new recurrent tumors were observed in three patients.Four patients were alive at the time of this report and the other four died of hepatorenal syndrome,liver failure,and progression of new recurrent tumors.CONCLUSION:Intraoperative RFA with tumor resection can be an alterative treatment option for HCC in locations difficult for a percutaneous approach. | Hyung Ook Kim Seung Kwon Kim Byung Ho Son Chang Hak Yoo Hyun Pyo Hong Yong Kyun Cho Byung Ik Kim | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 9 |
| 2 | Involvement of lymphocytes in dextran sulfate sodium-induced experimental colitis显示文摘瞄准:在葡聚糖硫酸盐的发展调查淋巴细胞的角色导致钠的大肠炎。方法:用葡聚糖硫酸盐钠(决策支持系统)的各种各样的剂量,我们在野类型的 B6 控制和 Rag-1 大美人( H-2b haplotype )导致了大肠炎鼠标,并且评估了大肠炎以征兆并且 histologic 参数例如重量损失,幸存,腹泻的严厉,冒号长度和组织学的变化的缺乏。征兆的参数每天被检查,组织学的变化被获得。结果:尽管在 Rag-1 猛烈老鼠的大肠炎的开发与决策支持系统的高剂量(5%) 对待比得上在 B6 控制老鼠,大肠炎前进在 Rag-1 猛烈老鼠与相比是更可容忍的比在与低剂量(1.5%) 对待的 B6 老鼠决策支持系统。征兆的参数以及组织病理学说的变化在 Rag-1 猛烈鼠标被改进。结论:这些结果显示淋巴细胞的存在在决策支持系统刺激的低剂量贡献大肠炎前进。淋巴细胞可以在导致决策支持系统的大肠炎作为一个加重的因素起作用。 | Tae Woon Kim Jae Nam Seo Young Ho Suh Hyo Jin Park Ju Hyun Kim Ji Young Kim Kwon Ik Oh | 2006 | World Journal of Gastroenterology2006，12，2： | 6 |
| 3 | Comparison of brush and basket cytology in differential diagnosis of bile duct stricture at endoscopic retrograde cholangiopancreatography显示文摘BACKGROUND: A previous report has identified a significantly higher sensitivity of cancer detection for dedicated grasping basket than brushing at endoscopic retrograde cholangiopancreatography (ERCP). This study aimed to compare the diagnostic accuracy of Geenen brush and Dormia basket cytology in the differential diagnosis of bile duct stricture.METHOD: The current study enrolled one hundred and fourteen patients who underwent ERCP with both Geenen brush and Dormia basket cytology for the differential diagnosis of bile duct stricture at our institution between January 2008 and December 2012.RESULTS: We adopted sequential performances of cytologic samplings by using initial Geenen brush and subsequent Dormia basket cytology in 59 patients and initial Dormia basket and subsequent Geenen brush cytology in 55 patients.Presampling balloon dilatations and biliary stentings for the stricture were performed in 17 (14.9%) and 107 patients (93.9%),respectively. The sensitivity, specificity, positive predictive value,negative predictive value, and accuracy of Geenen brush cytology for the diagnosis of malignant bile duct stricture were 75.0%,100.0%, 100.0%, 66.7% and 83.3%, respectively, and those of Dormia basket cytology were 64.5%, 100.0%, 100.0%, 58.5% and 76.3%, respectively (P=0.347 and 0.827 for sensitivity and accuracy, respectively). The good and excellent cellular yields (≥ grade 2) were obtained by Geenen brush and Dormia basket cytology in 88 (77.2%) and 79 (69.3%) patients, respectively.CONCLUSION: The sensitivity, specificity and accuracy of biliary sampling with a Dormia basket are comparable to those with conventional Geenen brush cytology in the detection of malignant bile duct stricture. | Ki Bae Bang Hong Joo Kim Jung Ho Park Dong Il Park Yong Kyun Cho Chong Il Sohn Woo Kyu Jeon Byung Ik Kim | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，6： | 5 |
| 4 | Different risk factors for advanced colorectal neoplasm in young adults显示文摘AIM: To compare the risk of developing advanced colorectal neoplasm(ACRN) according to age in Koreans.METHODS: A total of 70428 Koreans from an occupational cohort who underwent a colonoscopy between 2003 and 2012 at Kangbuk Samsung Hospital were retrospectively selected. We evaluated and compared odds ratios(OR) for ACRN between the young-adults(YA < 50 years) and in the older-adults(OA ≥ 50 years). ACRN was defined as an adenoma ≥ 10 mm in diameter, adenoma with any component of villous histology, high-grade dysplasia, or invasive cancer.RESULTS: In the YA group, age(OR = 1.08, 95%CI: 1.06-1.09), male sex(OR = 1.26, 95%CI: 1.02-1.55), current smoking(OR = 1.37, 95%CI: 1.15-1.63), family history of colorectal cancer(OR = 1.46, 95%CI: 1.01-2.10), diabetes mellitus related factors(OR = 1.27, 95%CI: 1.06-1.54), obesity(OR = 1.23, 95%CI: 1.03-1.47), CEA(OR = 1.04, 95%CI: 1.01-1.09) and low-density lipoprotein-cholesterol(OR = 1.01, 95%CI: 1.01-1.02) were related with an increased risk of ACRN. However, age(OR = 1.08, 95%CI: 1.06-1.09), male sex(OR = 2.12, 95%CI: 1.68-2.68), current smoking(OR = 1.38, 95%CI: 1.12-1.71), obesity(OR = 1.34, 95%CI: 1.09-1.65) and CEA(OR = 1.05, 95%CI: 1.01-1.09) also increased the risk of ACRN in the OA group.CONCLUSION: The risks of ACRN differed based on age group. Different colonoscopic screening strategies are appropriate for particular subjects with risk factors for ACRN, even in subjects younger than 50 years. | Ji Yeon Kim Yoon Suk Jung Jung Ho Park Hong Joo Kim Yong Kyun Cho Chong Il Sohn Woo Kyu Jeon Byung Ik Kim Kyu Yong Choi Dong Il Park | 2016 | World Journal of Gastroenterology2016，22，13： | 5 |
| 5 | Metabolic syndrome is associated with erosive esophagitis显示文摘AIM: To clarify whether insulin resistance and metabolic syndrome are risk factors for erosive esophagitis. METHODS: A case-control study was performed using the database of the Kangbuk Samsung Hospital Medical Screening Center. RESULTS: A total of 1679 cases of erosive esophagitis and 3358 randomly selected controls were included. Metabolic syndrome was diagnosed in 21% of the cases and 12% of the controls (P < 0.001). Multiple logistic regressions confirmed the association between erosive esophagitis and metabolic syndrome (Odds ratio, 1.25; 95% CI, 1.04-1.49). Among the components of metabolic syndrome, increased waist circumference, elevated serum triglyceride levels and hypertension were significant risk factors for erosive esophagitis (all P < 0.01). Furthermore, increased insulin resistance (Odds ratio, 0.91; 95% CI, 0.85-0.98) and fatty liver, as diagnosed by ultrasonography (Odds ratio, 1.39; 95% CI, 1.20-1.60), were also related to erosive esophagitis even after adjustment for a series of confounding factors. CONCLUSION: Metabolic syndrome and increased insulin resistance are associated with an increased risk of developing erosive esophagitis. | Jung Ho Park Dong IL Park Hong Joo Kim Yong Kyun Cho Chong IL Sohn Woo Kyu Jeon Byung Ik Kim | 2008 | World Journal of Gastroenterology2008，14，35： | 5 |
| 6 | Epidermal growth factor upregulates Skp2/Cks1 and p27^(kip1) in human extrahepatic cholangiocarcinoma cells显示文摘AIM:To evaluate the expression status of S-phase kinase-associated protein 2(Skp2)/cyclin-dependent kinases regulatory subunit 1(Cks1)and p27kip1,and assess the prognostic significance of Skp2/Cks1 expression with p27kip1in patients with extrahepatic cholangiocarcinoma.METHODS:Seventy-six patients who underwent curative resection for histologically confirmed extrahepatic cholangiocarcinoma at our institution from December1994 to March 2008 were enrolled.Immunohistochemical staining for Skp2,Cks1,p27kip1,and Ki67,along with other relevant molecular biologic experiments,were performed.RESULTS:By Cox regression analyses,advanced age(>65 years),advanced AJCC tumor stage,poorly differentiated histology,and higher immunostaining intensity of Skp2 were identified as independent prognostic factors in patients with extrahepatic cholangiocarcinoma.Exogenous epidermal growth factor(EGF,especially 0.1-10 ng/mL)significantly increased the proliferation indices by MTT assay and the mRNA levels of Skp2/Cks1 and p27kip1in SNU-1196,SNU-1079,and SNU-245 cells.The protein levels of Skp2/Cks1(from nuclear lysates)and p27kip1(from cytosolic lysate)were also significantly increased in these cells.There were significant reductions in the protein levels of Skp2/Cks1and p27kip1(from nuclear lysate)after the treatment of LY294002.By chromatin immunoprecipitation assay,we found that E2F1 transcription factor directly binds to the promoter site of Skp2.CONCLUSION:Higher immunostaining intensity of Skp2/Cks1 was an independent prognostic factor for patients with extrahepatic cholangiocarcinoma.EGF upregulates the mRNA and protein levels of Skp2/Cks1and p27kip1via the PI3K/Akt pathway and direct binding of E2F1 transcription factor with the Skp2 promoter. | Ja-yeon Kim Hong Joo Kim Jung Ho Park Dong Il Park Yong Kyun Cho Chong Il Sohn Woo Kyu Jeon Byung Ik Kim Dong Hoon Kim Seoung Wan Chae Jin Hee Sohn | 2014 | World Journal of Gastroenterology2014，20，3： | 4 |
| 7 | Systematic study of(MoTa)_(x)NbTiZr medium-and high-entropy alloys for biomedical implants-In vivo biocompatibility examination显示文摘In this study,the application of medium-and high-entropy(Mo Ta)_(x)Nb Ti Zr alloys in biomedical implants was systematically analyzed.The alloy with the best combination of mechanical properties was selected and characterized for in vitro and in vivo response for the first time to examine its biomedical properties.A logarithmic increase in the hardness and the yield strength was observed as a function of the Mo and Ta content.Alloys with up to 0.4 mol fraction of Mo and Ta showed a plastic strain of more than 30%under compression.The nanoindentation results showed that the addition of Mo and Ta increased the elastic modulus of the system linearly.It was surmised that the addition of Ta and Mo above a critical concentration(mole fraction=0.4)was unfavorable from a biomedical perspective as it increased the brittleness and elastic modulus and decreased the ductility of the system.Therefore,the(Mo Ta)_(0.2)Nb Ti Zr alloy is a potential structural material for biomedical implants because of its excellent strength and ductility.The developed alloy was investigated for its corrosion properties and compared with commercial biomedical alloys.Furthermore,the biocompatibility of the alloy was examined using an in vivo examination.The alloy was implanted in the skeletal muscles of mice for four weeks and the histology of the surrounding tissue was studied.The alloy exhibited strong passive behavior in a phosphate buffer solution and non-toxic soft tissue response. | Muhammad Akmal Ahtesham Hussain Muhammad Afzal Young Ik Lee Ho Jin Ryu | 2021 | Journal of Materials Science & Technology2021，，19： | 2 |
| 8 | The Effects of Aroma Acupuncture applied on Chronic Headache Patients显示文摘 | In Tae JUNG Su Yong KIM Doo Ik LEE Keon Sik KIM Jae Dong LEE Yun Ho LEE Do Young CHOI | 2005 | World Journal of Acupuncture-Moxibustion2005，15，3： | 2 |
| 9 | Clinical usefulness of 18F-FDG PET-CT for patients with gallbladder cancer and cholangiocarcinoma显示文摘 | Seung Won Lee Hong Joo Kim Jung Ho Park Dong Il Park Yong Kyun Cho Chong Il Sohn Woo Kyu Jeon Byung Ik Kim | 2010 | Journal of Gastroenterology2010，，5： | 2 |
| 10 | The microstructure, tensile properties, and creep behavior of AZ91, AS52 and TAS652 alloy显示文摘 | Byeong Ho Kim Sang Won Lee Yong Ho Park Ik Min Park | 2009 | Journal of Alloys and Compounds2009，，1： | 2 |
| 11 | Genetic variations in the PRKAA1 and ZBTB20 genes and gastric cancer susceptibility in a Korean population显示文摘 | Hye‐Rim Song Hee Nam Kim Sun‐Seog Kweon Jin‐Su Choi Hyun Jeong Shim Sang Hee Cho Ik Joo Chung Young‐Kyu Park Soo Hyun Kim Yoo‐Duk Choi Kyung Woong Joo Min‐Ho Shin | 2013 | Mol Carcinog2013，，1： | 2 |
| 12 | Motor functions but not learning and memory are impaired upon repeated exposure to sub-lethal doses of methyl parathion显示文摘 | Sun TY Paul IA Ho IK | 2006 | Journal of Biomedical Science2006，13，： | 1 |
| 13 | Boutorphanol: Effect of a prototypieal agonist-antagonist analgesic on kappa opioid receptors 显示文摘 | Commiskey S Fan LW Ho IK | 2005 | J Pharmacol Sci2005，98，： | 1 |
| 14 | Butorphanol:effects of a prototypical agonist-antagonist analgesic on kappa-opioid receptors显示文摘 | Commiskey S Fan LW Ho IK | 2005 | J Pharmacol Sci2005，98，2： | 1 |
| 15 | Butorphanol:effects of a proto-typical agonist-antagonist analgesic onκ-Opioidreceptors显示文摘 | Commiskey S Fan LW Ho IK | 2005 | JPharmacol Sci2005，98，2： | 1 |
| 16 | Screening of Chinese herbal drug extracts for inhibitory activity on nitric oxide production and identification of an active compound of Zanthoxylum bungeanum显示文摘 | YASUH IRO T SH HO I TAKU J IK | 2001 | Journal of Ethnopharmacology2001，77，23： | 1 |
| 17 | Health care utilization and indirect burden among families of ped- iatric patients with chronic pain显示文摘 | Ho IK Goldschneider KR Kashikar-Zuck S | 2008 | J Musculoskelet Pain2008，16，3： | 1 |
| 18 | Butorphanol :effects of a prototypical agonist-antagonist analgesic on kappa-opioid receptors 显示文摘 | Commiskey S Fan LW Ho IK | 2005 | J Pharmacol Sci2005，98，2： | 1 |
| 19 | Butorphanol: effect s of a prototypical agonist-antagonist analgesic on kappa-opioid receptors显示文摘 | Commiskey S Fan LW Ho IK et a l | 2005 | J Pharmacol Sci2005，98，： | 1 |
| 20 | Synthesis and luminescent properties of a novel Eu-containing nanoparticle 显示文摘 | Chang Ik Lee Jin Soo Lim Song Ho Kim Dong Hack Suh | 2006 | Polymer2006，47，： | 1 |
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