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| 1 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | Suppression of lipopolysaccharide- induced nuclear factor- kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages 显示文摘 | Pan M H Lin-shiau S Y Ho C T Lin J H Lin J K | 2000 | Biochem Pharm2000，59，： | 1 |
| 3 | Field - amplified sample stacking in capillary electrophoresis for the determination of clozapine, clozapine N - oxide, anddesmethylclozapine in schizophrenics' plasma显示文摘 | Ho Y H Ko W K Kou W S | 2004 | Journal of Chromatography B2004，809，： | 1 |
| 4 | 显示文摘 | Gong H Wilk G D | 2002 | Appl Phys Lett2002，81，： | 1 |
| 5 | The prevalence of iron deficiency anemia and its clinical implications in patients with colorectal carcinoma显示文摘 | Ho C H Yu Y B Wu P H | 2008 | J Chin Med Assoc2008，71，3： | 1 |
| 6 | Designing structure-specified mixed optimal controllers using an intelligent genetic algorithm IGA 显示文摘 | Ho S J Ho S Y Hung M H | 2005 | IEEE Trans on Control Systems Technology2005，13，6： | 1 |
| 7 | Stability and bifurcation of a rigidrotor-magnetic bearing system equipped with a thrustmagnetic bearing显示文摘 | Ho Y S Liu H Yu L | 2001 | Proc Inst Mech Engrs Part J: Journalof Engineering Tribology2001，215，5： | 1 |
| 8 | Characterization of tea catechins-loaded nanoparticles prepared from chitosan and an edible polypeptide显示文摘 | Tang D W Yu S H Ho Y C | | 0，，01： | 1 |
| 9 | Antiviral effect of epigallocatechin gallate on enterovirus 71显示文摘 | Ho H Y Cheng M L Weng S F | | 0，，14： | 1 |
| 10 | Colorectal neoplasia in Asia: a multicenter colonscopy survey in symptomatic patients显示文摘 | LEUNG W K HO K Y KIM W H | 2006 | Gastrointest Endosc2006，64，： | 1 |
| 11 | Adaptive fuzzy sliding mode control with chattering elimination for nonlinear SISO systems 显示文摘 | Ho H F Wong Y K Rad A B et | 2009 | Simulation Modelling Practice and Theory2009，17，7： | 1 |
| 12 | Integration of nitrogen and potassium signaling显示文摘 | Tsay Y F Ho C H Chen H Y | 2011 | Annual Review of Plant Biology2011，62，4： | 1 |
| 13 | Effects of nitrogen source availa- bility and hioreactor operating strategies on lutein production with Scervedesmus obllquus FSP-3 显示文摘 | Ho S H Xie Y Chart M C | 2015 | Bioresource Technology2015，184，： | 1 |
| 14 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 15 | Theaflavin-3,3'-digallat from black tea blocks the nitric oxide synthase by down-regulating the aetivation of NF- kappaB in macrophages 显示文摘 | Lin Y L Tsai S H Lin-Shiau S Y Ho C T Lin J K | 1999 | Eur J Pharmaeol1999，367，： | 1 |
| 16 | Does the involvement of private equity investments matter to fiem performance and internationliazation 显示文摘 | Tien C L Ho Y Chiu H J | 2008 | Journal of American Academy of Business2008，13，2： | 1 |
| 17 | Wnt modulators, SFRP-1, and SFRP-2 are expressed in osteoblasts and differentially regulate hematopoietic stem cells 显示文摘 | Nakajima H ho M Morikawa Y | 2009 | Biochem Biophys Res Commun2009，390，： | 1 |
| 18 | Arsenic compounds induce cyto toxicity and apoptosis in cisplatin-sensitive and-resistant gynecological cancer cell lines 显示文摘 | Du Y H Ho P C | 2001 | Cancer-Chemother-Pharmacol2001，47，6： | 1 |
| 19 | The components of the bid-ask spread in a limit-order market: evidence from the Tokyo Stock Exchange显示文摘 | Ahn H J Cai J Hamao Ho R Y K | 2002 | Journal of Empirical Finance2002，9，4： | 1 |
| 20 | Reduced expression of APC and DCC gene protein in breast cancer显示文摘 | Ho K Y Kalle W H Lo T H | 1999 | Histopathology1999，35，3： | 1 |
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