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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Efficient message passing interface(MPI) for parallel computing on clusters of workstations显示文摘 | Bruck J Dolev D Ho C H | 1997 | Journal of Parallel and Distributed Computing1997，40，1： | 2 |
| 3 | Suppression of lipopolysaccharide- induced nuclear factor- kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages 显示文摘 | Pan M H Lin-shiau S Y Ho C T Lin J H Lin J K | 2000 | Biochem Pharm2000，59，： | 1 |
| 4 | Designing structure-specified mixed optimal controllers using an intelligent genetic algorithm IGA 显示文摘 | Ho S J Ho S Y Hung M H | 2005 | IEEE Trans on Control Systems Technology2005，13，6： | 1 |
| 5 | Communication between eph- rinB2 and EphB4 within the osteoblast lineage 显示文摘 | Martin T J Allan E H Ho P W | 2010 | Adv Exp Med Biol2010，658，： | 1 |
| 6 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 7 | Theaflavin-3,3'-digallat from black tea blocks the nitric oxide synthase by down-regulating the aetivation of NF- kappaB in macrophages 显示文摘 | Lin Y L Tsai S H Lin-Shiau S Y Ho C T Lin J K | 1999 | Eur J Pharmaeol1999，367，： | 1 |
| 8 | Does the involvement of private equity investments matter to fiem performance and internationliazation 显示文摘 | Tien C L Ho Y Chiu H J | 2008 | Journal of American Academy of Business2008，13，2： | 1 |
| 9 | Nonbasal deformation modes of HCP metals and alloys: Role of dislocation source and mobility显示文摘 | Yoo M H Morris J R Ho K M | 2002 | Metall Mater Trans2002，33，： | 1 |
| 10 | Transport of ironbased nanoparticles: role of magnetic properties 显示文摘 | Yongsuk Ho Ryan J H Nosang V | 2009 | Environmental Science & Technology2009，43，23： | 1 |
| 11 | The components of the bid-ask spread in a limit-order market: evidence from the Tokyo Stock Exchange显示文摘 | Ahn H J Cai J Hamao Ho R Y K | 2002 | Journal of Empirical Finance2002，9，4： | 1 |
| 12 | An in situ heater for a phase-change-material-based actuation system 显示文摘 | Sant H J Ho T Gale B K | 2010 | Journal of Mieromeehanics and Mieroengineering2010，20，8： | 1 |
| 13 | Mango malformation disease in South China caused by Fus arium p roliferotum显示文摘 | ZHAN R L YANG S J HO H H LIU F ZHAO Y L CHANG J M HE Y B | 2010 | Journal of Phytopathology2010，158，： | 1 |
| 14 | Metaplastic breast carcinomas are basal-like tumours 显示文摘 | REIS-F H HO J S MILANEZI F | 2006 | Histopathology2006，49，1： | 1 |
| 15 | Maximum likelihood inference for mixtures of skew student-t-normal distributions through practical EM-type algorithms显示文摘 | HO H J PYNE S LIN T I | 2012 | Statistics and computing2012，22，1： | 1 |
| 16 | Adhesion and wear resistance of nitrided and TiN coated low alloy sreels 显示文摘 | Spies H J Larisch B Ho ck K | 1995 | Surface and Coationgs Technology1995，7475，： | 1 |
| 17 | Characteristic and antioxidant activity of retorted gelatin hydrolysates from cobia (Rachycentron canadum) skin显示文摘 | YANG J L HO H Y CHU Y J | 2008 | Food Chemistry2008，110，1： | 1 |
| 18 | Characteristic and antioxidant activity of retorted gelatin hydrolysates from cobia (Rachycentron canadum) skin 显示文摘 | Yang J L Ho H Y Chu Y J | 2008 | Food Chemistry2008，110，1： | 1 |
| 19 | Modeling of heat and carbon monoxide emitted from moving cars in an underground car park显示文摘 | Xue H Ho J C | 2000 | Tunneling and Underground Space Technology2000，15，1： | 1 |
| 20 | Structure and properties of cast binary Ti-Mo alloys 显示文摘 | HO W F JU C P CHERN-LIN J H | 1999 | Biomaterials1999，20，： | 1 |
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