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| 1 | Gastroesophageal reflux: the features in elderlypatients显示文摘AIM To compare the features ofgastroesophageal reflux disease between elderlyand younger patients.METHODS Twenty-four hour pH-monitoring andendoscopy were P6rformed for the 66 elderlypatients with typical gastroesophageaI refluxsymptoms, and the results were compared with112 symptomatic younger patients.RESULTS The results of 24-h pH-monitoringand endoscopy showed that the elderly patientshad pathological reflux and reflux esophagitismore frequently than the younger patients.P6rcentage time with pH< 4 in elderly patientswith reflux esophagitis was 32.5% in 24 hours,as compared with 12.9% in the younger patientswith reflux esophagitis (P < 0 .05 ). The elderlypatients with reflux esophagitis have longerP6riOds of acid reflux in both upright and Supinepositions than the younger patients. Endoscopyshowed that 20 .8% of elderIy patients had grade Ⅲ / Ⅳ esophagitis, whereas only 3.4% ofyounger patients had grade Ⅲ/ Ⅳ esophagitis(P < 0.002 ). Percentages of grades Ⅰ /Ⅱesophagitis in the two groups were 12.5% and26. 5%, respectiveIy (P< 0. 002 ).CONCLUSION Elderly patients, as comparedwith younger patients, have more severegastroesophageal reflux and esophageal lesions.The incompetence of lower esophageal sphincter and the presence of hiataI hernia may beimportant factors leading to the difference in incidence and severity of reflux esophagitisbetween elderly and younger patients. | Huang X Zhu HM Deng CZ Porro GB Sangaletti O Pace F | 1999 | World Journal of Gastroenterology1999，5，5： | 12 |
| 2 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 3 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 4 | Pathogenetic factors affecting gastroesophageal refluxin patients with esophagitis and concomitant duodenal ulcer:a multivariate analysis显示文摘Pathogeneticfactorsafectinggastroesophagealrefluxinpatientswithesophagitisandconcomitantduodenalulcer:amultivariateanalysisZH... | Zhu, HM Huang, X Deng, CZ Porro, GP Pace, F Sangaletti, O | 1998 | World Journal of Gastroenterology1998，4，2： | 2 |
| 5 | Posttraumatic hypothermia is neuroprotective in a model of traumatic brain injury complicated by a secondary hypoxic insult 显示文摘 | Matsushita Y Bramlett HM Alonso O | 2001 | Crit Care Med2001，29，11： | 1 |
| 6 | Imatinib mesylate (STI571) therapy for Philadelphia chromosome-positive chronic myelogenous leukemia in blast phase显示文摘 | Kantarjian HM Cortes J O'Brien S | 2002 | Blood2002，99，10： | 1 |
| 7 | Risk factors for stroke due to cerebral infarction in young adults显示文摘 | You RX Mcneil LL O' Malley HM | 1997 | Stroke1997，28，10： | 1 |
| 8 | Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity 显示文摘 | Jorgensen SB O' Neill HM Sylow L | 2013 | Diabetes2013，62，1： | 1 |
| 9 | Survival advantage with deeitabine versus intensive chemotherapy in patients with higher risk myelodysplastic syndrome: comparison with historical experience 显示文摘 | Kantarjian HM O'Brien S Huang X | 2007 | Cancer2007，109，6： | 1 |
| 10 | Survival benefit with imatinib mesylate therapy in patients with accelerated-phase chronic myelogenous leukemia-comparison with historic experience显示文摘 | Kantarjian HM Talpaz M O' Brien S | 2005 | Cancer2005，103，10： | 1 |
| 11 | The role of anterior spinal instrumentation and allograft fibula for the treatment of pott disease显示文摘 | Ozdemir HM Us AK O(g)ün T | 2003 | Spine2003，28，5： | 1 |
| 12 | Long-term survival benefit and improved complete cytogenetic and molecular response rates with imatinib mesylate in Philadelphia chromosome-positive chronic-phase chronic myeloid leukemia after failure of interferon-α显示文摘 | Kantarjian HM Cortes JE O'Brien S | 2004 | Blood2004，104，： | 1 |
| 13 | Posttraumatic hypothennia is nemopmtective in a model of traumatic brain injury complicated by a secondary insult 显示文摘 | Matshita Y Bramlett HM Alonso O | 2001 | Crit Care Med2001，29，11： | 1 |
| 14 | The capsular warning syndrome :pathogenesis and clinical features显示文摘 | Donnan GA O'Malley HM Quang L | 1993 | Neurology1993，43，5： | 1 |
| 15 | The role of anterior spinal instrumentation and allograft fibula for the treatment of pott disease显示文摘 | Ozdemir HM Us AK Oˇgün T | 2003 | Spine2003，5，： | 1 |
| 16 | Standardized patients in the early acquisition of clinical skills 显示文摘 | McGraw RC O' Connor HM | 1999 | Med Educ1999，33，8： | 1 |
| 17 | The role of anterior spinal instrumentation and allograft fibula for the treatment of pott disease显示文摘 | Ozdemir HM Us AK Oün T | 2003 | Spine2003，28，5： | 1 |
| 18 | Laparoscopic versus conventional colorectal resection:a prospective randomized study of postoperative ileus and early postoperative feeding显示文摘 | Schwenk W B(o)hm B Haase O | | 0，，01： | 1 |
| 19 | Results of treatment with hyper-CVAD,a dose-intensive regimen,in adult acute lymphocytic leukemia显示文摘 | Kantarjian HM O'Brien S Smith TL | 2000 | J Clin Oncol2000，18，3： | 1 |
| 20 | Interspecific and intraspecific horizontal transfer of Wolbachia in Drosophila显示文摘 | Boyle L O'Neill SL Robertson HM | | 0，，5115： | 1 |
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