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| 1 | Combination of pegylated interferon and lamivudine for patients with chronic hepatitis B who have failed treatment显示文摘BACKGROUND: Treatment of chronic hepatitis B (CHB) alone with interferon or lamivudine alone or in combination is effective in only a small proportion of patients. Treatment of patients in whom antiviral therapy fails is challenging. This study was made to determine the efficacy of combined pegylated interferon alpha (peg-IFN) and lamivudine in patients with CHB who had failed to respond to antiviral treatment. METHODS: Twenty patients with CHB proven by liver biopsy, with ALT levels >1.5×ULN,HBV DNA levels>141 500 copies/ml, and previous treatment failure with an adequate regimen were treated with a combination of peg-IFN 1.5μg/kg and lamivudine 100 mg/day for 52 weeks and followed up for a further 24 weeks. Biochemical response was defined as normalization of ALT and DNA response as HBV DNA<141 500 copies/ml. Secondary efficacy measures included HBsAg loss, HBeAg loss and appearance of anti-HBe (in cases of HBeAg-positive patients). RESULTS: Twenty patients were treated, of whom 16 were HBeAg positive. At 52 weeks, normal ALT was seen in 10 (50%) (8 of 16 HBeAg+ and 2 of 4 HBeAg), HBV DNA response in 5 (25%) (5 of 16 in HBeAg+ and none in HBeAg-), and HBeAg loss with appearance of anti-HBe in 5 (31.3%) of the 16 HBeAg positive patients. At 76 weeks, 8 (80%) of the 10 patients with normal ALT at 52 weeks relapsed, with normal ALT only in 2 (10%) (1 of 16 HBeAg+ and 1 of 4 HBeAg-), and all 5 patients who had a DNA response at 52 weeks relapsed at 76 weeks and had no DNA response. HBeAg loss with appearance of anti-HBe was seen in 1 (6.3%) of 16 HBeAg-positive patients. None of the patients lost HBsAg. CONCLUSIONS: The combination of peg-IFN and lamivudine for 52 weeks is not effective for treatment of CHB patients with a failed treatment. New treatment strategies need to be developed. | Shiv K.Sarin Manoj Kumar Syed Hissar Barjesh C.Sharma | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，3： | 3 |
| 2 | Comparison of low - dosepegylated interferon versus standard high - dose pegylated in-terferon in combination with ribavirin in patients with chronichepatitis C with genotype 3 : an Indian experience显示文摘 | Sood A Midha V Hissar S | 2008 | J Gas-troenterol Hepatol2008，23，2： | 1 |
| 3 | Decrease in CD4^ + T lymphocyte proliferation responses and enhanced CD150 cell expression in health care workers non - responsive to HBV vaccine 显示文摘 | Pati NT Sukriti Hissar S | 2007 | Vaccine2007，25，10： | 1 |
| 4 | Virologic and histologie features of chronic hepatitis B virus - infected asymptomatic patients with per- sistently normal ALT显示文摘 | Kumar M Sarin SK Hissar S | 2008 | Gastroenterology2008，134，5： | 1 |
| 5 | Decrease in CD4+ T lymphocyte proliferation responses and enhanced CD150 cell expression in health care workers non-responsive to HBV vaccine显示文摘 | Pati NT Hissar S Agrawal K | 2007 | Vaccine2007，25，10： | 1 |
| 6 | Circulating tregs cor- relate with viral load reduction in chronic HBV-treated patients with tenofovir disoproxil fumarate显示文摘 | TrehanPati N Kotillil S Hissar SS | 2011 | Clin Immunol2011，31，3： | 1 |
| 7 | Virologic and histologic features of chronic hepatitis B virusinfected asymptomatic patients with persistently normal ALT显示文摘 | Kumar M Sarin S K Hissar S | 2008 | Gastroenterology2008，134，： | 1 |
| 8 | Virologic and histologic features of chronic hepatitis B virus-infected asymptomatic patients with persistently normal ALT显示文摘 | Kumar M Sarin SK Hissar S | 2008 | Gastroenterology2008，134，5： | 1 |
| 9 | ,Immunological mechanisms of hepatitis B virus persistence in newborns显示文摘 | Trehanpati N Hissar S Shrivastav S | 2013 | The Indian journal of medical research2013，138，5： | 1 |
| 10 | Virologic and histologic features of chronic hepatitis B virus - infected asymptomatic patients with persistently normal AL T显示文摘 | KUMAR M SARIN SK HISSAR S | 2008 | Gastroenterology2008，134，5： | 1 |
| 11 | ImmunologicalmechanismsofhepatitisBviruspersistenceinnewborns显示文摘 | TrehanpatiN HissarS ShrivastavS etal | 2013 | IndianJMedRes2013，138，5： | 1 |
| 12 | Virologic and histologic features of chronic hepatitis B virus-infected asymptomatic patients with persistently normal ALT显示文摘 | Kumar M Sarin SK Hissar S | 2008 | Gastroenterology2008，134，5： | 1 |
| 13 | Risk factors analysis for hepatocellular carcinoma in patients with and without cirrhosis: A case-control study of 213 hepatocellular carcinoma patients from India 显示文摘 | Kumar M Kumar R Hissar SS | 2007 | Gastroenterol Hepatol2007，22，7： | 1 |
| 14 | Risk factors analysis for hepatocellular carcinoma in patients with and without cirrhosis:a casecontrol study of 213 hepatocellular carcinoma patients from India显示文摘 | Kumar M Kumar R Hissar SS | | 0，，： | 1 |
| 15 | Virologic and histologic features of chronic hepatitis B virus-infected asymptomatic patients with persistently normal ALT显示文摘 | Kumar M Sarin SK Hissar S | 2008 | Gastroenterology2008，134，5： | 1 |
| 16 | Virologicandhistologic features of chronic hepatitis B virus infected asymptomatic patients with persistently normal AL T显示文摘 | KUMARM SARINSK HISSARS | 2008 | Gastroenterology2008，134，5： | 1 |
| 17 | Impaired monocyte‐macrophage functions and defective toll‐like receptor signaling in hepatitis E virus‐infected pregnant women with acute liver failure显示文摘 | Rashi Sehgal Sharda Patra Paul David Ashish Vyas Arshi Khanam Syed Hissar Ekta Gupta Guresh Kumar Shyam Kottilil Rakhi Maiwall Shiv Kumar Sarin Nirupama Trehanpati | 2015 | Hepatology2015，，6： | 1 |
| 18 | Virologic and Histologic Features of Chronic Hepatitis B Virus-Infected Asymptomatic Patients With Persistently Normal ALT显示文摘 | Manoj Kumar Shiv K. Sarin Syed Hissar Chandana Pande Puja Sakhuja Barjesh Chander Sharma Ranjit Chauhan Sujoy Bose | 2008 | Gastroenterology2008，，5： | 1 |
| 19 | Virologic and histologic features of chronic hepatitis B virus-infected asymptomatic patients with persistently normal ALT 显示文摘 | KUMAR M SARIN S K HISSAR S | 2008 | Gastroenterology2008，134，5： | 1 |
| 20 | Virologic and histo- logic features of chronic hepatitis B virus infected asympto- matic patients with persistently normal ALT显示文摘 | KUMAR M SARIN SK HISSAR S | 2008 | Gastroenter- ology2008，134，5： | 1 |
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