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| 1 | Diabetes mellitus: The epidemic of the century显示文摘The epidemic nature of diabetes mellitus in different regions is reviewed. The Middle East and North Africa region has the highest prevalence of diabetes in adults(10.9%) whereas, the Western Pacific region has the highest number of adults diagnosed with diabetes and has countries with the highest prevalence of diabetes(37.5%). Different classes of diabetes mellitus, type 1, type 2, gestational diabetes and other types of diabetes mellitus are compared in terms of diagnostic criteria, etiology and genetics. The molecular genetics of diabetes received extensive attention in recent years by many prominent investigators and research groups in the biomedical field. A large array of mutations and single nucleotide polymorphisms in genes that play a role in the various steps and pathways involved in glucose metabolism and the development, control and function of pancreatic cells at various levels are reviewed. The major advances in the molecular understanding of diabetes in relation to the different types of diabetes in comparison to the previous understanding in this field are briefly reviewed here. Despite the accumulation of extensive data at the molecular and cellular levels, the mechanism of diabetes development and complications are still not fully understood. Definitely, more extensive research is needed in this field that will eventually reflect on the ultimate objective to improve diagnoses, therapy and minimize the chance of chronic complications development. | Akram T Kharroubi Hisham M Darwish | 2015 | World Journal of Diabetes2015，6，6： | 53 |
| 2 | Fusobacterium 's link to colorectal neoplasia sequenced: A systematic review and future insights显示文摘AIM To critically evaluate previous scientific evidence on Fusobacterium's role in colorectal neoplasia development.METHODS Two independent investigators systematically reviewed all original scientific articles published between January,2000,and July,2017,using Pub Med,EMBASE,and MEDLINE. A total of 355 articles were screened at the abstract level. Of these,only original scientific human,animal,and in vitro studies investigating Fusobacterium and its relationship with colorectal cancer(CRC) were included in the analysis. Abstracts,review articles,studies investigating other colonic diseases,and studies written in other languages than English were excluded from our analysis. Ninety articles were included after removing duplicates,resolving disagreements between the two reviewers,and applying the above criteria.RESULTS Studies have consistently identified positive associations between Fusobacterium,especially Fusobacterium nucleatum(F. nucleatum),and CRC. Stronger associations were seen in CRCs proximal to the splenic flexure and Cp G island methylator phenotype(CIMP)-high CRCs. There was evidence of temporality and a biological gradient,with increased F. nucleatum DNA detection and quantity along the traditional adenoma-carcinoma sequence and in CIMP-high CRC precursors. Diet may have a differential impact on colonic F. nucleatum enrichment;evidence suggests that high fiber diet may reduce the risk of a subset of CRCs that are F. nucleatum DNA-positive. Data also suggest shorter CRC and disease-specific survival with increased amount of F. nucleatum DNA in CRC tissue. The pathophysiology of enrichment of F. nucleatum and other Fusobacterium species in colonic tissue is unclear;however,the virulence factors and changes to the local colonic environment with disruption of the protective mucus layer may contribute. The presence of a host lectin(Gal-Gal NAc) in the colonic epithelium may also mediate F. nucleatum attachment to CRC and precursors through interaction with an F. nucleatum protein,fibroblast activation protein 2(FAP2). The clinical significance of detection or enrichment of Fusobacterium in colorectal neoplasia is ambiguous,but data suggest a procarcinogenic effect of F. nucleatum,likely due to activation of oncogenic and inflammatory pathways and modulation of the tumor immune environment. This is hypothesized to be mediated by certain F. nucleatum strains carrying invasive properties and virulence factors such as Fad A and FAP.CONCLUSION Evidence suggests a potential active role of Fusobacterium,specifically F. nucleatum,in CRC. Future prospective and experimental human studies would fill an important gap in this literature. | Hisham Hussan Steven K Clinton Kristen Roberts Michael T Bailey | 2017 | World Journal of Gastroenterology2017，23，48： | 9 |
| 3 | Plastic/compact heat exchangers for single effect desalination systems 显示文摘 | Hisham T EI-Dessouky Hisham M Ettouney | 1999 | Desalination1999，122，23： | 1 |
| 4 | Performance of parallel feed multiple effect evaporation system for seawater desalination显示文摘 | Hisham T El-Dessouky Hisham Mettouney | 2000 | Applied Thermal Engineering2000，20，： | 1 |
| 5 | Multi-effect evaporation desalination systems:thermal analysis显示文摘 | Hisham T El-Dessouky Hisham Mettouney | 1999 | Desalination1999，125，： | 1 |
| 6 | Dynamic interfacial tension of crude oil/alkali/surfactant systems显示文摘 | HISHAM A NASR E D KEVIN C T | 1992 | Colloids and Surfaces1992，66，： | 1 |
| 7 | The effect of synthetic surfactants on the interracial behavior of crude oil/alkali/polymer systems显示文摘 | Kevin C T Hisham A Nasr- EL- Din | 1996 | Colloids and Surfaces A:Physieochemical and Engineering Aspects1996，108，1： | 1 |
| 8 | Plastic/compact heat exchangers for single-effect desalination systems显示文摘 | El-Dessouky Hisham T Ettouney Hisham M | 1999 | Desalination1999，112，： | 1 |
| 9 | Multiple-effect evaporation desalination systems:thermal analysis 显示文摘 | Hisham T El-Dessouky H M Ettouney | 1999 | Desalination1999，125，： | 1 |
| 10 | Reversed halo sign in invasive pulmonary fungal infections显示文摘 | Hisham Wahba Mylene T Truong Xiudong | 2008 | Clinical Infectious Diseases2008，46，11： | 1 |
| 11 | Performanee of wire mesh mist eliminator显示文摘 | Hisham T El Dessouky Imad M Alafiqi | 2000 | Chemical Engineering and Processing2000，39，2： | 1 |
| 12 | Performance of evaporative condensers 显示文摘 | Hishamm Ettouney Hisham T | 2001 | Heat Transfer Engineering2001，22，： | 1 |
| 13 | Recognition of the avascular space medial to the upper pole of the thyroid and its surgical implications显示文摘 | Hisham A Bliss R Reeve T | 2000 | Asian J Surg2000，23，1： | 1 |
| 14 | Prevertebral soft tissue measurements in thyroid enlargement: the value of lateral neck radiographs 显示文摘 | Hisham A N Sarojah A Mastura T | 2004 | Asian J Surg2004，27，3： | 1 |
| 15 | Experimental investigation of the performance of two-stage evaporative coolers显示文摘 | Amir A AL-Haddad Hisham T EL-Dessouky | 1997 | Heat Transfer Engineering1997，18，2： | 1 |
| 16 | Performance of three-dimensional slope stability methods in practice 显示文摘 | Timothy D S Hisham T | 1998 | Journal ofGeotechnical and Geo-environmental engineering1998，124，11： | 1 |
| 17 | Performance of wire mesh mist eliminator显示文摘 | Hisham T El-Dessouky | 2000 | Chemical Engineer-ing and Processing2000，，39： | 1 |
| 18 | Genetic evidence that antibacterial activity of lysozyme is independent of its catalytic function显示文摘 | HISHAM R IBRAHIM M MATSUZAKI T | 2001 | FEBS2001，506，： | 1 |
| 19 | HDPE Geomembrane/Geo-textile Interface Shear Strength显示文摘 | Timothy D Stark Thomas A Wiliamson Hisham T Eid | 1996 | Journal of Geotechnical Engineering1996，，3： | 1 |
| 20 | Performance of wire mesh mist eliminator显示文摘 | HISHAM T EL DEDDOUKY IMAD M ALAFFIQI | 2000 | Chemical Engineering and Processing2000，39，2： | 1 |
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