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| 1 | Rubber band ligation for 750 cases of symptomatic hemorrhoids out of 2200 cases显示文摘AIM: To study the results for the treatment of symptomatic hemorrhoids using rubber band ligation (RBL) method. METHODS: A retrospective study for 750 patients who came to the colorectal unit from June, 1998 to September, 2006, data was retrieved from archived fi les. RBL was performed using the Mc Gown applicator on an outpatient basis. The patients were asked to return to out-patient clinic for follow up at 2 wk, 1 mo, 6 mo and through telephone call every 6 mo for 2 years). RESULTS: After RBL, 696 patients (92.8%) were cured with no difference in outcome for second or third degree hemorrhoids (P = 0.31). Symptomatic recurrence was detected in 11.04% after 2 years. A total of 52 patients (6.93%) had 77 complications from RBL which required no hospitalization. Complications were pain, rectal bleeding and vaso-vagal symptoms(4.13%, 4.13% and 1.33% of patients, respectively). At 1 mo there were a significant improvement in mean SF-36 scores over baseline in five items, while after 2 years there were improvement in all items over baseline, but not significant. No significant manometeric changes after band ligation. CONCLUSION: RBL is a simple, safe and effective method for treating symptomatic second and third degree hemorrhoids as an out patient procedure with signifi cant improvement in quality of life. RBL doesn't alter ano-rectal functions. | Ayman M El Nakeeb Amir A Fikry Waleed H Omar Elyamani M Fouda Tito A El Metwally Hosam E Ghazy Sabry A Badr Mohmed Y Abu Elkhar Salih M Elawady Hisham H Abd Elmoniam Waiel W Khafagy Mosaad M Morshed Ramadan E El Lithy Mohamed E Farid | 2008 | World Journal of Gastroenterology2008，14，42： | 24 |
| 2 | Relationship between vitamin D and IL-23,IL-17 and macrophage chemoattractant protein-1 as markers of fibrosis in hepatitis C virus Egyptians显示文摘AIM:To assess vitamin D in hepatitis C patients and its relationship to interleukin (IL)-23, IL-17, and macrophage chemoattractant protein-1 (MCP-1). METHODS:The study was conducted on 50 Egyptian hepatitis C virus (HCV) genotype number IV-infected patients and 25 ageand gender-matched healthy subjects. Venous blood samples were obtained. Samples were allowed to clot and sera were separated by centrifugation and stored at -20 ℃. A 25 hydroxy vitamin D assay was carried out using solid phase RIA. A 1,25 dihydroxy vitamin D assay was carried out using a commercial kit purchased from Incstar Corporation. IL-17 and -23 and MCP-1 were assayed by an enzyme immunoassay. Quantitative and qualitative polymerase chain reaction for HCV virus were done by TaqMan technology. Only HCV genotype IV-infected subjectswere included in the study. The mean ± SD were determined, a t-test for comparison of means of different parameters was used. Correlation analysis was done using Pearson's correlation. Differences among different groups were determined using the Kruskal-Wallis test. RESULTS:The mean vitamin D level in HCV patients (groupⅠ) was 15 ± 5.2 ng/mL while in control (group Ⅱ) was 39.7 ± 10.8. For active vitamin D in groupⅠas 16.6 ± 4.8 ng/mL while in group Ⅱ was 41.9 ± 7.9. IL-23 was 154 ± 97.8 in group Ⅰ and 6.7 ± 2.17 in group Ⅱ. IL-17 was 70.7 ± 72.5 in cases and 1.2 ± 0.4 in control. MCP-1 was 1582 ± 794.4 in group Ⅰand 216.1 ± 5.38 in group Ⅱ. Vitamin D deficiency affected 72% of HCV-infected patients and 0% of the control group. Vitamin D insufficiency existed in 28% of HCV-in-fected patients and 12% of the control group. One hundred percent of the cirrhotic patients and 40% of non cirrhotic HCV-infected patients had vitamin D deficiency. IL-23, IL-17, and MCP-1 were markedly increased in HCV-infected patients in comparison to controls.A significant negative correlation between vitamin D and IL-17 and-23 and MCP-1 was detected. HCV-infected males and females showed no differences with respect to viral load, vitamin D levels, IL-17, IL-23 and MCP-1. The viral load was negatively correlated with vitamin D and active vitamin D (P = 0.0001 and P = 0.001, respectively), while positively correlated with IL-23, IL-17, and MCP-1. We classified the patients according to sonar findings into four groups. Group Ⅰa with bright hepatomegaly and included 14 patients. Group Ⅰb with perihepatic fibrosis and included 11 patients. Group Ⅰc with liver cirrhosis and included 11 patients. Group Ⅰd with he patocellular carcinoma (HCC) and included 14 patients. Vitamin D and active vitamin D were shown to be lower in cirrhotic patients and much lower in patients with HCC, and this difference was highly significant (P = 0.0001). IL-17 and-23 and MCP-1 were higher in advanced liver disease) and the differences were highly significant (P = 0.0001).CONCLUSION:Whether the deficiency of vitamin D is related to HCV-induced chronic liver disease or predisposing factor for higher viral load is a matter of debate. | Noha M El Husseiny Hala M Fahmy Waleed A Mohamed Hisham H Amin | 2012 | World Journal of Hepatology2012，4，8： | 12 |
| 3 | Genetic barriers in transplantation medicine显示文摘The successful of transplantation is determined by the shared human leukocyte antigens(HLAs) and ABO blood group antigens between donor and recipient. In recent years, killer cell receptor [i.e., killer cell immunoglobulinlike receptor(KIR)] and major histocompatibility complex(MHC) class I chain-related gene molecule(i.e., MICA) were also reported as important determinants of transplant compatibility. At present, several different genotyping techniques(e.g., sequence specific primer and sequence based typing) can be used to characterize blood group, HLA, MICA and KIR and loci. These molecular techniques have several advantages because they do not depend on the availability of anti-sera, cellular expression and have greater specificity and accuracy compared with the antibody-antigen based typing. Nonetheless, these molecular techniques have limited capability to capture increasing number of markers which have been demonstrated to determine donor and recipient compatibility. It is now possible to genotype multiple markers and to the extent of a complete sequencing of the human genome using next generation sequencer(NGS). This high throughput genotyping platform has been tested for HLA, and it is expected that NGS will be used to simultaneously genotype a large number of clinically relevant transplantation genes in near future. This is not far from reality due to the bioinformatics support given by the immunogenetics community and the rigorous improvement in NGS methodology. In addition, new developments in immune tolerance based therapy, donor recruitment strategies and bioengineering are expected to provide significant advances in the field of transplantation medicine. | Hisham A Edinur Siti M Manaf Nor F Che Mat | 2016 | World Journal of Transplantation2016，6，3： | 4 |
| 4 | Stem cell applications for pathologies of the urinary bladder显示文摘New stem cell based therapies are undergoing intense research and are widely investigated in clinical fields including the urinary system. The urinary bladder performs critical complex functions that rely on its highly coordinated anatomical composition and multiplex of regulatory mechanisms. Bladder pathologies resulting in severe dysfunction are common clinical encounter and often cause significant impairment of patient's quality of life. Current surgical and medical interventions to correct urinary dysfunction or to replace an absent or defective bladder are sub-optimal and are associated with notable complications. As a result, stem cell based therapies for the urinary bladder are hoped to offer new venues that could make up for limitations of existing therapies. In this article, we review research efforts that describe the use of different types of stem cells in bladder reconstruction, urinary incontinence and retention disorders. In particular, stress urinary incontinence has been a popular target for stem cell based therapies in reported clinical trials. Furthermore, we discuss the relevance of the cancer stem cell hypothesis to the development of bladder cancer. A key subject that should not be overlooked is the safety and quality of stem cell based therapies introduced to human subjects either in a research or a clinical context. | Noha A Mousa Hisham A Abou-Taleb Hazem Orabi | 2015 | World Journal of Stem Cells2015，7，5： | 2 |
| 5 | Visual and refractive outcomes of posterior chamber phakic IOL in stable keratoconus显示文摘We evaluated the visual and refractive outcomes after phakic visian toric implantable collamer lens(ICL) insertion in stable keratoconus(KC). This retrospective study investigated toric ICL implantation in 14 eyes of 8 patients with stable KC. After 6 mo, the mean uncorrected distance visual acuity improved significantly from 0.77 to 0.15 logMAR. The mean best corrected distance visual acuity(BCDVA) improved from 0.18±0.1 to 0.15±0.1 logMAR. Fifty percent of eyes maintained their preoperative BCDVA; 42.8% gained one line. There was no statistical difference in high order or coma aberration. The mean refractive manifest spherical equivalent(MSE), mean refractive manifest spherical error, mean manifest astigmatism decreased significantly postoperatively. At 6 mo postoperatively, our achieved mean spherical equivalent was approximately 74%. No intraoperative or postoperative complications occurred. Toric ICL implantation was effective, predictable and safe to correct refractive error and improve visual acuity in patients with stable KC. | Sherif H Emerah Moataz M Sabry Hisham A Saad Waleed A Ghobashy | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 2 |
| 6 | A simulation-based optimization frame- work for product development cycle time reduction 显示文摘 | HISHAM M A BAO H | 2006 | IEEE Transact ions on Engineering Management2006，53，1： | 1 |
| 7 | Guaianolide glucosides from Elephan- topus scaber 显示文摘 | Hisham A Pieters I Claeys M | 1992 | Planta Med1992，58，5： | 1 |
| 8 | Analysis of single-effect evaporator desalination systems combined with vapor compression heat pumps显示文摘 | FAISAL A J HISHAM E D HISHAM E | 1997 | Desalination1997，114，3： | 1 |
| 9 | Uvariamicin I, II and III, three novel acetogenins from Uvaria narum 显示文摘 | Hisham A Pieters LAC Claeys M | 1990 | Tetrahedron Lett1990，31，32： | 1 |
| 10 | Salacianone and salacianol,two triterpenes from Salacia beddomei显示文摘 | HISHAM A KUMAR G J FUJIMOTO Y | 1995 | Phytochemistry1995，40，： | 1 |
| 11 | Acetogenins from root bark of Uvaria narum 显示文摘 | Hisham A Pieters LAC Claeys M | 1991 | Phytochemistry1991，30，7： | 1 |
| 12 | Piezoelectric actuators and sensors location for active control of flexible structures显示文摘 | Sylvaine L Hisham A K Yvan B | 2001 | IEEE Transactions on Instrumentation and Measurement2001，50，6： | 1 |
| 13 | Dynamic interfacial tension of crude oil/alkali/surfactant systems显示文摘 | HISHAM A NASR E D KEVIN C T | 1992 | Colloids and Surfaces1992，66，： | 1 |
| 14 | Variation of the fracture toughness of concrete with temperature显示文摘 | Hisham Abdel-Fattah Sameer A Hamoush | 1997 | 11(2):1051997，11，2： | 1 |
| 15 | Lessons learned from using viscoelastic surfactants in well stimulation显示文摘 | Hisham A Nasr-El-Din Mathew Samuel | 2007 | SPE 903832007，，： | 1 |
| 16 | The effect of synthetic surfactants on the interracial behavior of crude oil/alkali/polymer systems显示文摘 | Kevin C T Hisham A Nasr- EL- Din | 1996 | Colloids and Surfaces A:Physieochemical and Engineering Aspects1996，108，1： | 1 |
| 17 | Newgel aggregates to improve sweep efficiency during water-flooding显示文摘 | Lei Guanglun Li Lingling Nasr-El-Din Hisham A | 2011 | SPE Reservoir Evaluation&Engineering2011，4，1： | 1 |
| 18 | Spectrophotometric and atomic absorption spectrometric determination of certain cephalosporins显示文摘 | Magda M Ayad Abdalla A Shalaby Hisham E Abdel- later | 1999 | Journal of Pharmaceutical and Biomedical Analysis1999，18，： | 1 |
| 19 | Sulfur removal from model diesel fuel using granular activated carbon from dates' stones activated by ZnC12显示文摘 | Yahia A Alhamed Hisham S Bamufleh | 2009 | Fuel2009，88，1： | 1 |
| 20 | Effects of sur- gical approach on functional outcomes of open reduction and internal fixation of intra-articular distal humeral frac- tures; a systematic review显示文摘 | Karin L L Matthew C B Hisham A | 2012 | J Shoulder Elbow Surg2012，21，1： | 1 |
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