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| 1 | Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure. | Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz | 2021 | Bioactive Materials2021，6，12： | 7 |
| 2 | 确保硫酸的质量显示文摘奥托昆普技术公司Klaus Hasselwander先生论述如何利用现有技术确保硫磺制酸和冶炼烟气制酸装置的产品质量。对硫磺制酸装置,主要是采用可靠的过滤技术,例如带有预涂层的叶式过滤机。对冶炼烟气制酸装置,一是提高净化工序的效率,必要时增设除氟和除汞装置;二是对成品酸进行漂白、除汞、除氧化氮。北德意志冶金公司Hanno Hintze先生介绍该公司在汉堡的冶炼烟气制酸装置为提高硫酸质量所采取的一些措施。 | Klaus Hasselwander Hanno Hintze 王爱群 | 2006 | 硫酸工业2006，，1： | 4 |
| 3 | Einteilung und Behandlung von Gallengangverletzungen nach laparoskopischer Cholecystektomie显示文摘 | P. Neuhaus S. C. Schmidt R. E. Hintze A. Adler W. Veltzke R. Raakow J. M. Langrehr W. O. Bechstein | 2000 | Der Chirurg2000，，2： | 3 |
| 4 | Surgical management of proximal bile duct cancer: extended right lobe resection increases resectability and radicality显示文摘 | Peter Neuhaus Sven Jonas Utz Settmacher Armin Thelen Christoph Benckert Enrique Lopez-H?nninen Rainer E. Hintze | 2003 | Langenbeck’s Archives of Surgery2003，，3： | 2 |
| 5 | Staging of Klatskin tumours (hilar cholangiocarcinomas): comparison of MR cholangiography, MR imaging, and endoscopic retrograde cholangiography显示文摘 | Thomas J. Vogl Wolfram O. Schwarz Matthias Heller Christopher Herzog Stephan Zangos Rainer E. Hintze Peter Neuhaus Renate M. Hammerstingl | 2006 | European Radiology2006，，10： | 2 |
| 6 | Partial growth-hormone insensitivity: The role of growth-hormone receptor mutations in idiopathic short stature显示文摘 | Audrey D. Goddard Patrick Dowd Steven Chernausek Mitchell Geffner Joseph Gertner Raymond Hintz Nancy Hopwood Selna Kaplan Leslie Plotnick Alan Rogol Robert Rosenfield Paul Saenger Nellie Mauras Richard Hershkopf Morris Angulo Kenneth Attie | 1997 | The Journal of Pediatrics1997，，1： | 2 |
| 7 | Endoscopic Sphincterotomy Using an S-shaped Sphincterotome in Patients with a Billroth II or Roux-en-Y Gastrojejunostomy显示文摘 | R. E. Hintze W. Veltzke A. Adler H. Abou-Rebyeh | 1997 | Endoscopy1997，，02： | 2 |
| 8 | Sensor measurement seheduling: an enhanced dynamic preemptive algorithm显示文摘 | MCINTYRE G A HINTZ K J | 1998 | Optical Engineering1998，37，2： | 1 |
| 9 | Maerophage inflammatory protein-lalpha(not T helper type 2 eytokines) is associated with severe forms of respiratory syneytial virus bronchiolitis显示文摘 | GAROFALO R P PATTI J HINTZ K A | 2001 | Infect Dis2001，184，4： | 1 |
| 10 | Thrombolytic therapy preserves vagal activity early after acute myocardial infarction显示文摘 | Lind P Hintze U Moller M | 2001 | Scand Cardiovase J2001，35，2： | 1 |
| 11 | Neurodevelopmental and growth outcomes of extremely low birth weight infants after necrotizing enterocolitis显示文摘 | Hintz SR Kendrick DE Stoll BJ | 2005 | Pediatrics2005，115，3： | 1 |
| 12 | Electrochemical properties and corrosion protection of organosilane self-assem-bled monolayers on aluminum 2024-T3 显示文摘 | Hintze P E Calle L M | 2006 | Electro- chimica Acta2006，51，8： | 1 |
| 13 | Accuracy of caries detection with four storage phosphor systems and E - speed radiographs 显示文摘 | Hintze H Wenzel A Frydenberg M | 2002 | Dentomaxillofac Radiol2002，31，3： | 1 |
| 14 | Cone beam CT and conventional tomography for the detection of morphological temporomandibular joint changes显示文摘 | Hintze H Wiese M Wenzel A | 2007 | Dentomaxillofac Radiol2007，36，4： | 1 |
| 15 | Stereomicroscopy, film radiography, microradiography and naked-eye inspection of tooth sections as validation for occlusal caries diagnosis 显示文摘 | Wenzel A Larsen MJ | 1995 | Caries-Res1995，29，： | 1 |
| 16 | Influence of culture parameters on biological hydrogen production by Clostridium saccharoperbutylacetonicum ATCC 27021 显示文摘 | Ferchichi M Crabbe E Hintz W | 2005 | World Journal of Microbiology and Biotechnology2005，2，67： | 1 |
| 17 | Hepcidin: a critical regulator of iron metabolism during hypoxia显示文摘 | Hintze KJ McClung JP | 2011 | Adv Hematol2011，，51： | 1 |
| 18 | Occurrence and propagation of delamination during the machining of carbon fibre reinforced plastics (CFRPs) – An experimental study显示文摘 | Wolfgang Hintze Dirk Hartmann Christoph Schütte | 2011 | Composites Science and Technology2011，，15： | 1 |
| 19 | Hypothermia therapy for neonatal hypoxic ischemic encephalopathy in the state of California显示文摘 | Kracer B Hintz SR Van Meurs KP | 2014 | J Pediatr2014，165，2： | 1 |
| 20 | Cellular regulation and molecu- lar interactions of the ferritins显示文摘 | Hintze KJ Theil EC | 2006 | Cell Mol Life Sci2006，63，5： | 1 |
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