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| 1 | Fecal microbes, short chain fatty acids, and colorectal cancer across racial/ethnic groups显示文摘AIM:To investigate differences in microbes and short chain fatty acid(SCFA) levels in stool samples from Hispanic and non-Hispanic African American,American Indian,and White participants.METHODS:Stool samples from twenty participants were subjected to analysis for relative levels of viable bacteria and for SCFA levels.Additionally,the samples were subjected to 16 S r RNA gene pyrosequencing for identification of bacteria present in the stool.We used a metagenome functional prediction technique to analyze genome copy numbers and estimate the abundance of butyrate kinase in all samples.RESULTS:We found that African Americans had significantly lower levels of acetate,butyrate,and total SCFAs than all other racial/ethnic groups.We also found that participant microbial profiles differed by racial/ethnic group.African Americans had significantly more Firmicutes than Whites,with enriched Ruminococcaceae.The Firmicutes /Bacteroidetes ratio was also significantly higher for African Americans than for Whites(P =0.049).We found Clostridium levels to be significantly and inversely related to total SCFA levels(P =0.019) and we found Bacteroides to be positively associated(P =0.027) and Clostridium to be negatively associated(P =0.012) with levels of butyrate.We also identified a correlation between copy number for a butyrate kinase predicted from 16 S r RNA gene abundance and levels of butyrate in stool.CONCLUSION:The identified differences in gut flora and SCFA levels may relate to colorectal cancer mortality differentials and may be useful as targets for future clinical and behavioral interventions. | Christina M Hester Venkatakrishna R Jala Morgan GI Langille Shahid Umar K Allen Greiner Bodduluri Haribabu | 2015 | World Journal of Gastroenterology2015，21，9： | 2 |
| 2 | Fetal Growth Restriction: Mechanisms, Epidemiology, and Management显示文摘Fetal growth restriction(FGR)is the condition in which a fetus does not reach its intrinsic growth potential and in which the shortterm and long-term risks of severe complications are increased.FGR is a frequent complication of pregnancy with a complex etiology and limited management options,other than timely delivery.The most common pathophysiological mechanism is placental insufficiency,due to many underlying causes such as maternal vascular malperfusion,fetal vascular malperfusion and villitis.Identifying truly growth restricted fetuses remains challenging.To date,FGR is often defined by a cut-off of the estimated fetal weight below a certain percentile on a population-based standard.However,small fetal size as a single marker does not discriminate adequately between fetuses or newborns that are constitutionally small but healthy and fetuses or newborns that are growth restricted and thus at risk for adverse outcomes.In 2016,the consensus definition of FGR was internationally accepted to better pinpoint the FGR population.In this review we will discuss the contemporary diagnosis and management issues.Different diagnostic markers are considered,like Doppler measurements,estimated fetal growth,interval growth,fetal movements,biomarkers,and placental markers. | Hester D.Kamphof Selina Posthuma Sanne J.Gordijn Wessel Ganzevoort | 2022 | Maternal-Fetal Medicine2022，4，3： | 2 |
| 3 | Prospective Quality Initiative to Maximize Dysphagia Screening Reduces Hospital-Acquired Pneumonia Prevalence in Patients With Stroke显示文摘 | W. Lee Titsworth Justine Abram Amy Fullerton Jeannette Hester Peggy Guin Michael F. Waters J Mocco | 2013 | Stroke2013，，11： | 2 |
| 4 | 广泛经皮针刀筋膜切断术联合脂肪移植术:一种治疗掌腱膜挛缩的新疗法显示文摘背景手术切除治疗掌腱膜挛缩症复发率高且康复时间延长。本文将介绍一种新型微创手术替代治疗掌腱膜挛缩症的方法及其成果。方法过程包括采用广泛经皮针刀筋膜切断术将束带完全松解,并与真皮分离。随后,由此产生的松弛组织用以自体脂肪填充。术后伸直位制动1周,然后,建议术后3~6个月患者白天可以正常用手,夜间伸直位固定。本组患者共91例(99只手),手术在迈阿密和鹿特丹进行;对50例患者的手部伸展角度进行测量(平均随访44周)。结果近端指间关节挛缩的治疗效果显著,伸展角度由61°改善至27°,掌指关节挛缩的伸展角度由37°改善至-5°。94%患者在2~4周内手部恢复正常功能,95%患者对结果非常满意。无新的瘢痕生成,大部分恢复了柔软的手掌脂肪垫。发生了1例神经损伤的并发症,1例术后切口感染,4例复杂区域疼痛综合征。结论这一新的微创技术缩短了康复时间,增加了缺损的皮下脂肪组织,产生了柔软无痕的皮肤。并且有能力处理多个掌指纹,可解决整只手的异常情况。治疗过程安全有效,尤其对首次治疗者。目前,前瞻性随机对照研究过程充分确定了其治疗掌腱膜挛缩症的作用。(循证医学证据等级:Ⅳ级,疗法) | Steven E. R. Hovius Hester J. Kan Xander Smit Ruud Wf Selles Eufimiano Cardoso Roger K. Khouri 李可竹(译) 郭澍(译) 孙强(译) 魏峰(译) 高景恒(译) | 2013 | 中国美容整形外科杂志2013，24，1： | 2 |
| 5 | Laparoscopic Resection for Colorectal Cancer in Octogenarians: Results in a Decade显示文摘 | Hester Y. S. Cheung F.R.A.C.S. C. C. Chung F.R.C.S.(Edinb.) James T. K. Fung M.R.C.S. James C. H. Wong F.R.A.C.S. Kevin K. K. Yau F.R.C.S.(Edinb.) Michael K. W. Li F.R.C.S.(Edinb.) F.R.C.S.(Engl.) | 2007 | Diseases of the Colon & Rectum2007，，11： | 2 |
| 6 | The use of perfusion CT for the evaluation of therapy combining AZD2171 with gefitinib in cancer patients显示文摘 | Martijn R. Meijerink Hester Cruijsen Klaas Hoekman Matthijs Kater Cors Schaik Jan Hein T. M. Waesberghe Giuseppe Giaccone Radu A. Manoliu | 2007 | European Radiology2007，，7： | 2 |
| 7 | Going, Going, Gone: Lost Internet References 显示文摘 | Robert P Dellavalle E Hester J | 2003 | Science2003，302，5646： | 1 |
| 8 | Inhibition of cytomegalovirus infection by lactoferrin in vitro and in vivo显示文摘 | Leonie Beljaars Barry W A van der Strate Hester I Bakker | 2004 | Antiviral Research2004，63，： | 1 |
| 9 | Executive dysfunction in cocaine addiction: Evidence for discordant frontal, cingulate, and cerebellar activity 显示文摘 | Hester R Garavan H | 2004 | J Neurosci2004，24，11： | 1 |
| 10 | Formaldehydeinduced gene expression in F344 rat nasal respiratory epithelium显示文摘 | HESTER S D BENAVIDES G B YOON L | 2003 | Toxicology2003，187，1： | 1 |
| 11 | The mode of vasoinhibitory action of a pyridazinone derivative (MCI-154),a new cardiotonic agent,on contractile responses induced by alpha-adrenoceptor agonists and ^45Ca influx in isolated vascular smooth muscles显示文摘 | Shibata S Satake N Hester RK Kurahashi K Ito M | 1988 | Eur J Pharmacol1988，145，2： | 1 |
| 12 | A pilot randomised con- trolled trial of modafinil during acute methamphetamine withdraw- al: Feasibility, tolerability and clinical outcomes显示文摘 | Lee N Pennay A Hester R | 2012 | Drug Alco- hol Rev2012，，： | 1 |
| 13 | Perceived external prestige and internal respect: new insights into the organizational identification process显示文摘 | Fuller J B Hester K | 2006 | Human Relations2006，59，6： | 1 |
| 14 | Diabetic painful neuropathy:current and future treatment opitions显示文摘 | Chong MS Hester J | 2007 | Drugs2007，67，12： | 1 |
| 15 | Gas hydrate measurements at Hydrate Ridge using Raman spectroscopy显示文摘 | HESTER K C DUNK R M WHITE S N | 2007 | Geochimica et Cosmochimica Acta2007，71，： | 1 |
| 16 | Financial disintermediation and policy显示文摘 | Hester D D | 1969 | Journal of Money Credit and Banking1969，，3： | 1 |
| 17 | Preparationof pH-responsive polymer membranes by self-organiza-tion显示文摘 | Hester J F Olugebefola S C Mayes A M | 2002 | J Membr Sci2002，208，： | 1 |
| 18 | Dif- ferential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS显示文摘 | HESTER KD D VERHELLE L ESCOUBET-LOZACH | 2007 | Cell Cycle2007，6，： | 1 |
| 19 | Cancer pain: part 2: physical, interventional and complimentary therapies; management in the community; acute, treatment-related and complex cancer pain: a perspective from the British Pain Society endorsed by the UK Association of Palliative Medicine and the Royal College of General Practitioners显示文摘 | Raphael J Hester J Ahmedzai S | 2010 | Pain Med2010，11，6： | 1 |
| 20 | Multivariant technique for multiclass pattern recognition 显示文摘 | Hester C F Casasent D | 1980 | Applied Optics1980，19，11： | 1 |
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